Serum Level of Uromodulin as an Early Predictor Marker of Kidney Disorders
DOI:
https://doi.org/10.3889/oamjms.2021.5663Keywords:
Dietary therapy, Herbs, Metabolic diseases, Obesity, Serum uromodulin, Whole grainsAbstract
BACKGROUND: Metabolic diseases are known to be risk factors of kidney injury. The glycoprotein Uromodulin Tamm-Horsfall protein is a biochemical marker specifically synthesized and secreted by kidney tubular epithelial cells.
AIM: The study aimed to use novel biochemical parameters to predict early changes in renal functions and to use natural food supplements to help in the prevention and management of such conditions.
METHODS: Crossover studies comparing two interventions trials. Subjects: Seventy obese females were included in this study. They were divided in two groups, first group (34 women) with mean age 45.82 ± 1.51 and mean body mass index (BMI) 35.65 ± 0.68 kg/m2, and second group (36 women) with mean age 49.80 ± 2.27, and mean BMI 37.67 ± 1.59. Intervention: All participants have followed a low caloric balanced regimen (1000–1200 Kcal/day) of the each groups consumed a different specific nutritional supplement composed mainly of whole grains and herbs. All patients were monitored clinically, anthropometrically, dietary 24 h recall and biochemically.
RESULTS: After intervention all the recorded anthropometric parameters showed significant decreases at p ≤ 0.05–0.01. The serum uromodulin (sUMOD) increased significantly after intervention in both groups the increments were 15.56 and 9.37%. Numerically creatinine and urea decreased, while creatinine clearance increased.
CONCLUSION: Data revealed the importance of using dietary therapy composed of hypocaloric diet with supplements made from whole grains and special herbs in management of obesity and its metabolic disorders. sUMOD proved to be an accurate biochemical marker that showed the kidneys’ response to the management in comparison to using usual diagnostic markers.
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Chen J, Gu D, Chen CS, Wu X, Hamm L, Muntner P, et al. Association between the metabolic syndrome and chronic kidney disease in Chinese adults. Nephrol Dial Transplant. 2007;22(4):1100-6. https://doi.org/10.1093/ndt/gfl759 PMid:17272313
Lea J, Cheek D, Thornley-Brown D, Appel L, Agodoa L, Contreras G, et al. Metabolic syndrome, proteinuria, and the risk of progressive CKD in hypertensive African Americans. Am J kidney Dis. 2008;51(5):732-40. https://doi.org/10.1053/j.ajkd.2008.01.013 PMid:18436083
Nugent RA, Fathima SF, Feigl AB, Chyung D. The burden of chronic kidney disease on developing nations: A 21st century challenge in global health. Nephron Clin Pract. 2011;118(3):c269-77. https://doi.org/10.1159/000321382 PMid:21212690
Laliberté F, Bookhart BK, Vekeman F, Corral M, Duh MS, Bailey RA, et al. Direct all-cause health care costs associated with chronic kidney disease in patients with diabetes and hypertension: A managed care perspective. J Manag Care Pharm. 2009;15(4):312-22. https://doi.org/10.18553/jmcp.2009.15.4.312 PMid:19422271
Ohta M, Babazono T, Uchigata Y, Iwamoto Y. Comparison of the prevalence of chronic kidney disease in Japanese patients with Type 1 and Type 2 diabetes. Diabet Med. 2010;27(9):1017-23. https://doi.org/10.1111/j.1464-5491.2010.03049.x PMid:20722675
Altun B, Süleymanlar G, Utaş C, Arınsoy T, Ateş K, Ecder T, et al. Prevalence, awareness, treatment and control of hypertension in adults with chronic kidney disease in Turkey: Results from the CREDIT study. Kidney Blood Press Res. 2012;36(1):36-46. https://doi.org/10.1159/000339025 PMid:22832670
Hallan S, de Mutsert R, Carlsen S, Dekker FW, Aasarød K, Holmen J. Obesity, smoking, and physical inactivity as risk factors for CKD: Are men more vulnerable? Am J Kidney Dis. 2006;47(3):396-405. https://doi.org/10.1053/j.ajkd.2005.11.027 PMid:16490617
EL-Nahass A, Bello AK. Chronic kidney disease: The global challenge. Lancet. 2005;95(9456):331-40. PMid:15664230
Iseki K, Kohagura K, Sakima A, Iseki C, Kinjo K, Ikemiya Y, et al. Changes in the demographics and prevalence of chronic kidney disease in Okinawa, Japan (1993 to 2003). Hypertens Res. 2007;30(1):55-62. https://doi.org/10.1291/hypres.30.55 PMid:17460372
Afifi A, Karim MA. Renal replacement therapy in Egypt: First annual report of the Egyptian society of Nephrology, 1996. East Mediterr Health J. 1999;5(5):1023-9. PMid:10983543
Afifi A, El Setouhy M, El Sharkawy M, Ali M, Ahmed H, El-Menshawy O, et al. Diabetic nephropathy as a cause of end-stage renal disease in Egypt: A six-year study. East Mediterr Health J. 2004;10(4-5):620-6. PMid:16335654
Then C, Then H, Lechner A, Huth C, Meisinger C, Heier M, et al. Serum uromodulin is inversely associated with the metabolic syndrome in the KORA F4 study. Endocr Connect. 2019;8(10):1363-71. https://doi.org/10.1530/ec-19-0352 PMid:31505464
Brunati M, Rampoldi L. Kidney diseases associated with uromodulin (Tamm-Horsfall protein. G Ital Nefrol. 2015;32 Suppl 64:gin/32.S64.10. PMid:26479057
Rees K, Takeda A, Martin N, Ellis L, Wijesekara D, Vepa A, et al. Mediterranean-style diet for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2019;3(3):CD009825. https://doi.org/10.1002/14651858.cd009825.pub3 PMid:30864165
Rees K, Hartley L, Flowers N, Clarke A, Hooper L, Thorogood M, et al. ‘Mediterranean’ dietary pattern for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013;8:CD009825. https://doi.org/10.1002/14651858.cd009825.pub2 PMid:23939686
Lankinen M., Uusitupa M., Schwab U. Nordic diet and inflammation-a review of observational and intervention studies. Nutrients. 2019;11(6):1369. https://doi.org/10.3390/nu11061369 PMid:31216678
Messias Rda S, Galli V, Silva SD, Schirmer MA, Rombaldi CV. Micronutrient and functional compounds biofortification of maize grains. Crit Rev Food Sci Nutr. 2015;55(1):123-39. https://doi.org/10.1080/10408398.2011.649314 PMid:24915397
Zeng Y, Pu X, Yang J, Du J, Yang X, Li X, et al. Preventive and therapeutic role of functional ingredients of barley grass for chronic diseases in human beings. Oxid Med Cell Longev. 2018;2018:3232080. https://doi.org/10.1155/2018/3232080 PMid:29849880
Guiné RP, Gonçalves FJ. Bioactive compounds in some culinary aromatic herbs and their effects on human health. Mini Rev Med Chem. 2016;16(11):855-66. https://doi.org/10.2174/138955751 6666160211120540 PMid:26864553
AOAC. 2000 Official Methods of Analysis of AOAC International. 17th ed. Maryland, USA: North Frederick Avenue Gaithersburg; 2000. p. 2877-417.
Kazuyoshi T, Yuuko I. Comparison of digestion methods for atomic absorption analysis of food materials. Anal Sci. 1992;8:419-21.
Mazurek B, Chmiel M, Górecka B. Food Analytical Methods. Berlin: Springer; 2017.
Cheung LM, Cheung PC, Ooi VE. Antioxidant activity and total phenolics of edible mushroom extracts. Food Chem. 2003;81:249- 55. https://doi.org/10.1016/s0308-8146(02)00419-3
Hiernaux J, Tanner JM. Growth and Physical Studies in Humanbiology: A Guide to Field Methods No. 23, World Food Dietary Assessment System; 1969.
Allain CC, Poon LS, Chan CS, Richmond WF, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20(4):470-5. https://doi.org/10.1093/clinchem/20.4.470 PMid:4818200
Wornick DF, Albers JJ. A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol. J Lipid Res. 1978;19(1):65-76. https://doi.org/10.1016/s0022-2275(20)41577-9 PMid:202660
Lhotta K. Uromodulin and chronic kidney disease. Kidney Blood Press Res. 2010;33(5):393-8. https://doi.org/10.1159/000320681 PMid:20948228
Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. https://doi.org/10.1159/000180580 PMid:1244564
Fawcett JK, Scott JE. A rapid and precise method for the determination of urea. J Clin Pathol. 1960;13(2):156-9. PMid:13821779
Risch L, Lhotta K, Meier D, Medina-Escobar P, Nydegger UE, Risch M. The serum uromodulin level is associated with kidney function. Clin Chem Lab Med. 2014;52(12):1755-61. https://doi.org/10.1515/cclm-2014-0505 PMid:24933630
Bjornstad P, Wiromrat P, Johnson RJ, Sippl R, Cherney DZ, Wong R, et al. Serum uromodulin predicts less coronary artery calcification and diabetic kidney disease over 12 years in adults with Type 1 diabetes: The CACTI study. Diabetes Care. 2019;42(2):297-302. https://doi.org/10.2337/dc18-1527 PMid:30482755
Steubl D, Block M, Herbst V, Nockher WA, Satanovskij R, Angermann S, et al. Plasma uromodulin correlates with kidney function and identifies early stages in chronic kidney disease patients. Medicine (Baltimore). 2016;95(10):e3011. https://doi.org/10.1097/md.0000000000003011 PMid:26962815
Scherberich JE, Gruber R, Nockher WA, Christensen EI, Schmitt H, Herbst V, et al. Serum uromodulin-a marker of kidney function and renal parenchymal integrity. Nephrol Dial Transplant. 2018;33(2):284-95. https://doi.org/10.1093/ndt/ gfw422 PMid:28206617
Pivin E, Ponte B, de Seigneux S, Ackermann D, Guessous I, Ehret G, et al. Uromodulin and nephron mass. Clin J Am Soc Nephrol. 2018;12(10):1556-7. https://doi.org/10.2215/cjn.03600318 PMid:30054352
D’Agati VD, Chagnac A, de Vries AP, Levi M, Porrini E, Herman- Edelstein M, et al. Obesity-related glomerulopathy: Clinical and pathologic characteristics and pathogenesis. Nat Rev Nephrol. 2016;12(8):453-71. https://doi.org/10.1038/nrneph.2016.75 PMid:27263398
Chagnac A, .Weinstein T, Korzets A, Ramadan E, Hirsch J, Gafter U. Glomerular hemodynamics in severe obesity. Am J Physiol Renal Physiol. 2000;278(5):F817-22. https://doi.org/10.1152/ajprenal.2000.278.5.f817 PMid:10807594
Rosenberg AZ, Kopp JB. Focal segmental glomerulosclerosis. Clin J Am Soc Nephrol. 2017;12(3):502-17. PMid:28242845
Scheurlen KM, Billeter AT, Kopf S, Herbst V, Block M, Nawroth PP, et al. Serum uromodulin and Roux-en-Y gastric bypass: Improvement of a marker reflecting nephron mass. Surg Obes Relat Dis. 2019;15(8):1319-25. https://doi.org/10.1016/j.soard.2019.05.002 PMid:31239098
Manna P, Jain SK. Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: Causes and therapeutic strategies. Metab Syndr Relat Disord. 2015;13(10):423-44. https://doi.org/10.1089/met.2015.0095 PMid:26569333
LaFavers KA, Macedo E, Garimella PS, Lima C, Khan S, Myslinski J, et al. Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel. Sci Transl Med. 2019;11(512):eaaw3639. https://doi.org/10.1126/scitranslmed.aaw3639 PMid:31578243
Farhadnejad H, Asghan G, Mirmiran P, Yuzbashian E, Azizi F. Micronutrient intakes and incidence of chronic kidney disease in adults: Tehran lipid and glucose study. Nutrients. 2016;8(4):217. https://doi.org/10.3390/nu8040217 PMid:27104561
Zhou JY, Ge H, Zhu MF, Wang LJ, Chen L, Tan YZ, et al. Neck circumference as an independent predictive contributor to cardio-metabolic syndrome. Cardiovasc Diabetol. 2013;12:76. https://doi.org/10.1186/1475-2840-12-76 PMid:23680280
Preis SR, Massaro JM, Hoffmann U, D’Agostino RB Sr., Levy D, Robins SJ, et al. Neck circumference as a novel measure of cardiometabolic risk: The Framingham heart study. J Clin Endocrinol Metab. 2010;95(8):3701-10. https://doi.org/10.1210/jc.2009-1779 PMid:20484490
Köttgen A, Glazer NL, Dehghan A, Hwang SJ, Katz R, Li M, et al. Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet. 2009;41(6):712-7. PMid:19430482
Köttgen A, Hwang SJ, Larson MG, van Eyk JE, Fu Q, Benjamin EJ, et al. Uromodulin levels associate with a common UMOD variant and risk for incident CKD. J Am Soc Nephrol. 2010;21(2):337-44. https://doi.org/10.1681/asn.2009070725 PMid:19959715
Trudu M, Janas S, Lanzani C, Debaix H, Schaeffer C, Ikehata M, et al. Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression. Nat Med. 2013;19:1655-60. https://doi.org/10.1038/nm.3384 PMid:24185693
Leiherer A, Muendlein A, Saely CH, Ebner J, Brandtner EM, Fraunberger P, et al. Serum uromodulin is a predictive biomarker for cardiovascular events and overall mortality in coronary patients. Int J Cardiol. 2017;231:6-12. https://doi.org/10.1016/j. ijcard.2016.12.183
PMid:28089453
Delgado GE, Kleber ME, Scharnagl H, Krämer BK, März W, Scherberich JE. Serum uromodulin and mortality risk in patients undergoing coronary angiography. J Am Soc Nephrol. 2017;28(7):2201-10. https://doi.org/10.1681/asn.2016111162 PMid:28242751
Wilson PW, D’Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97(18):1837-47. https://doi.org/10.1161/01.cir.97.18.1837 PMid:9603539
World Health Organization. The World Health Report 2002: Reducing Risks, Promoting Healthy Life. Geneva: World Health Organization; 2002. https://doi.org/10.1016/j.agecon.2003.11.006
Webb D. The impact of whole grains on health. Todays Dietitian. 2013;15(5):44.
Giacco R, Pepa GD, Luongo D, Riccardi G. Whole grain intake in relation to body weight: From epidemiological evidence to clinical trials. Nutr Metab Cardiovasc Dis. 2011;21(12):901-8. https://doi.org/10.1016/j.numecd.2011.07.003 PMid:22036468
Williams C, Ronco C, Kotanko P. Whole grains in the renal diet-is it time to reevaluate their role? Blood Purif. 2013;36(3- 4):210-4.https://doi.org/10.1159/000356683 PMid:24496192
Sharangi AB, Guha S. Wonders of leafy spices: Medicinal properties ensuring human health. Sci Int. 2013;1(9):312-7. https://doi.org/10.17311/sciintl.2013.312.317
Yang M, Liu C, Jiang J, Zuo G, Lin X, Yamahara J, et al. Ginger extract diminishes chronic fructose consumption-induced kidney injury through suppression of renal overexpression of proinflammatory cytokines in rats. BMC Complement Altern Med. 2014;14:174. https://doi.org/10.1186/1472-6882-14-174
Latona DF, Oyeleke GO, Olayiwola OA. Chemical analysis of ginger root. IOSR J Appl Chem 2012;1:47-9.
Boissonneault GA, Clinical and Scientific Affairs Council of the AAPA. Obesity: The current treatment protocols. JAAPA. 2009;22(1):18-9. PMid:19248355
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Copyright (c) 2021 Salwa Mostafa El-Shebini, Hend A. Essa, Maha I. A. Moaty, Nihad H. Ahmed, Ahmed M. S. Hussein, Magda S. Mohamed, Salwa T. Tapozada (Author)
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