Insulin-like Growth Factor Initiates Hepatocellular Carcinoma in Chronic Hepatitis C Virus Patients through Induction of Long Non-coding Ribonucleic Acids AF085935: Role of LncRNA AF085935 in HCC development

Abeer  Mostafa; Noha El-Sayed Ibrahim; Dina  Sabry; Wael Fathy; Amany Y.  Elkazaz

doi:10.3889/oamjms.2021.5909

Authors

Abeer Mostafa Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Giza, Cairo, Egypt
Noha El-Sayed Ibrahim Department of Microbial Biotechnology, Genetic Engineering and Biotechnology Division, National Research Centre, Dokki, Giza, Egypt https://orcid.org/0000-0002-7176-4687
Dina Sabry Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Giza, Cairo, Egypt; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Badr University in Cairo, Badr City, Egypt https://orcid.org/0000-0002-6720-3385
Wael Fathy Department of Tropical Medicine, Faculty of Medicine, Beni Seuf University, Beni Seuf, Egypt
Amany Y. Elkazaz Department of Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

DOI:

https://doi.org/10.3889/oamjms.2021.5909

Keywords:

Hepatitis C virus, Hepatocellular carcinoma, Insulin-like growth factor, Forkhead box class O and long non-coding ribonucleic acid AF085935

Abstract

Abstract

HCV is the most commonly occurring hepatic infection worldwide. Chronic HCV infection usually complicated with cirrhosis and even HCC with significant morbidity and mortality. The aim of this study to clarify the molecular mechanism by which HCV can induce HCC and identify a new diagnostic marker for early detection of HCC. Methods: 180 participating subject were divided in to three groups. Group 1: 60 healthy individuals (controls). Group 2: 60 HCV infected patients. Group 3: 60 HCV patients developed HCC. Serum IGF, FOXO and LncRNA AF085935 were evaluated. Results: Serum IGF was significantly elevated in HCV and HCC patients, while FOXO and LncRNA AF085935 were significantly up regulated in HCC. IGF significantly correlated with and LncRNA AF085935. Conclusion: HCV can induce IGF with subsequent induction of LncRNA AF085935 and FOXO.

Key word: HCV, HCC, IGF, FOXO and LncRNA AF085935.

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