The Comparison between Free Thyroxine and Thyroid-Stimulating Hormone Levels on Melasma Severity: A Cross-Sectional Study:  Comparing FT4 and TSH on Melasma Severity

Yusnita Rahman; Roro Inge Ade Krisanti; Wismandari Wisnu; Irma Bernadette S. Sitohang

doi:10.3889/oamjms.2021.5952

Authors

Yusnita Rahman Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia
Roro Inge Ade Krisanti Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia
Wismandari Wisnu Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia
Irma Bernadette S. Sitohang Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.5952

Keywords:

Melasma, Modified melasma area and severity index, Janus II facial analysis system, Thyroid-stimulating hormone, Free T4

Abstract

Background: Melasma has been suspected to be linked with levels of thyroid hormone. There is no study that explains the association between thyroid hormone level with melasma severity. Objective: This study aims to find the discrepancies in the levels of thyroid hormone in varying severity of melasma by using two different measurement techniques. Methods: Subjects were chosen consecutively from the dermatology clinic at RSUPN Dr. Cipto Mangunkusomo hospital. Forty-eight patients participated in this study were categorized into mild melasma and moderate-severe melasma based on modified melasma area and severity index (mMASI) and Janus II measurement. Results: Statistically, mMASI measurement showed no significant association between varying melasma severity with levels of thyroid stimulating hormone and free T4 (FT4), P 0.375 and P 0.208, respectively. The Janus II examination using polarized light modality has a weak positive correlation with the serum FT4 level (r=0.3; P 0.039). Weak correlation was also found between the two measurement strategies, Janus II and mMASI (r= 0.314; P 0.03). Conclusion: There are no significant differences observed in levels of thyroid hormone between subjects with varying degrees of melasma severity.

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