Pathophysiology and Diagnostic Evaluation of Occupational Asthma from Exposure to Wood Dust and Diisocyanates in the Wood Processing Employees: A Preliminary Study

Authors

  • Eko Prasetyo Doctoral Study Program of Medical/Health Sciences, Faculty of Medicine, Diponegoro University, Semarang, Indonesia; Public Health Study Program, STIKES Cendekia Utama Kudus, Kudus, Indonesi
  • Anies Anies Faculty of Medicine, Diponegoro University, Semarang, Indonesia
  • Nyoman Suci Widyastiti Faculty of Medicine, Diponegoro University, Semarang, Indonesia
  • Suhartono Suhartono Faculty of Public Health, Diponegoro University, Semarang, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.5989

Keywords:

Etiology, Pathophysiology, Diagnostic Evaluation Occupational Asthma, Diisocyanates

Abstract

AIM: This study is a preliminary study to analyze the etiology and pathophysiology of exposure to wood dust and diisocyanates in the wood processing industry in Jepara, Central Java, Indonesia. This study also provides a diagnostic evaluation of occupational asthma (OA) for ongoing exposure.

METHODS: The research method was carried out with a systematic review of various previous findings and with a preliminary study of workers in the processing industry in Jepara, Indonesia.

RESULTS: The results show that from a sample of 32 respondents who have been carried out in a wood processing factory in Jepara, it shows that the suspect OA in sanding workers by hand is 75%, with the distribution of signs and symptoms: Chest tightness and pain (90%); cough (53%); shortness of breath (50%); and wheezing (2%). From the signs and symptoms felt, workers felt a continuous increase (progressivity) of OA by 75%.

CONCLUSION: Theoretically, this preliminary study is useful to provide information about exposure to wood dust and diisocyanates as a risk factor for OA, especially among workers in the wood industry.

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References

International Labour Organization. ILO List of Occupational Diseases. Geneva, Switzerland: ILO; 2010.

Anies. Kedokteran Okupasi; Berbagai Penyakit Akibat Kerja dan Upaya Penanggulangan dari Aspek Kedokteran. Yogyakarta: Ar-Ruzz Media; 2014.

Bernstein DI, Korbee L, Bernstein A, Scinto J, Herd ZL, Leonard I. Clinical aspects of allergic disease. J Allergy Clin Immunol. 1993;10:158-64.

Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol. 2005;15(1):3. PMid:15864889

Sripaiboonkij P, Phanprasit W, Jaakkola MS. Respiratory and skin effects of exposure to wood dust from the rubber tree Hevea brasiliensis. Occup Environ Med. 2009;66(7):442-7. https://doi.org/10.1136/oem.2008.042150 PMid:19188201 DOI: https://doi.org/10.1136/oem.2008.042150

Carlsten C, Dybuncio A, Pui MM, Chan-Yeung M. Respiratory impairment and systemic inflammation in cedar asthmatics removed from exposure. PLoS One. 2013;8(2):e57166. https://doi.org/10.1371/journal.pone.0057166 PMid:23468925 DOI: https://doi.org/10.1371/journal.pone.0057166

Ratnasingam J, Ioras F, Tadin I, Wai LT, Ramasamy G. Respitarory effect in woodworkers exposed to wood and wood coatings dust: A regional evaluation of South East Asian countries. J Appl Sci. 2014;14(15):1763-8. https://doi.org/10.3923/jas.2014.1763.1768 DOI: https://doi.org/10.3923/jas.2014.1763.1768

Pollaris L, Devos F, De Vooght V, Seys S, Nemery B, Hoet PH, et al. Toluene diisocyanate and methylene diphenyl diisocyanate: Asthmatic response and cross-reactivity in a mouse model. Arch Toxicol. 2016;90(7):1709-17. https://doi.org/10.1007/s00204-015-1606-6 PMid:26468151 DOI: https://doi.org/10.1007/s00204-015-1606-6

Alimudiarnis A. Diagnosis dan Penatalaksanaan Asma Akibat Kerja. Padang: Universitas Andalas; 2018.

Yeung C, Malo JL. Occupational asthma. N Engl J Med. 2007;333(2):107-12. DOI: https://doi.org/10.1056/NEJM199507133330207

Beckett WS. Occupational respiratory diseases. N Engl J Med. 2000;342(6):406-13. PMid:10666432 DOI: https://doi.org/10.1056/NEJM200002103420607

Tarlo SM, Lemiere C. Occupational asthma. N Engl J Med. 2014;370(7):640-9. PMid:24521110 DOI: https://doi.org/10.1056/NEJMra1301758

Dröge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82(1):47-95. PMid:11773609 DOI: https://doi.org/10.1152/physrev.00018.2001

Arkhaesi N. Kadar Malondialdehyde (MDA) Serum Sebagai Indikator Prognosis Keluaran Pada Sepsis Neonatorum. Semarang: Universitas Diponegoro; 2008.

McDonald JC. Incidence by occupation and industry of acute work related respiratory diseases in the UK, 1992-2001. Occup Environ Med. 2005;62(12):836-42. https://doi.org/10.1136/oem.2004.019489 PMid:16299091 DOI: https://doi.org/10.1136/oem.2004.019489

Cocker J. Biological monitoring for isocyanates. Occup Med (Lond). 2007;57(6):391-3. PMid:17728308 DOI: https://doi.org/10.1093/occmed/kql148

Hegmann KT, Biggs JJ, Hughes MA, Jolly AT, Klees JE, Bohnker BK, et al. Contributors to the Occupational/Work- Related Asthma Guideline; 2016. p. 154.

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Published

2021-04-29

How to Cite

1.
Prasetyo E, Anies A, Widyastiti NS, Suhartono S. Pathophysiology and Diagnostic Evaluation of Occupational Asthma from Exposure to Wood Dust and Diisocyanates in the Wood Processing Employees: A Preliminary Study. Open Access Maced J Med Sci [Internet]. 2021 Apr. 29 [cited 2024 Nov. 26];9(E):317-23. Available from: https://oamjms.eu/index.php/mjms/article/view/5989

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Public Health Disease Control

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