Correlation of Melanin Content with Collagen Density in Keloid Patients

Herman Y. L. Wihastyoko; David S. Perdanakusuma; Setyawati Soeharto; Edi Widjajanto; Kusworini Handono; Bambang Pardjianto

doi:10.3889/oamjms.2021.6002

Authors

Herman Y. L. Wihastyoko Doctoral Program, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia; Plastic, Aesthetic and Reconstruction Surgery Consultant, Saiful Anwar General Hospital, Malang 65111, Indonesia
David S. Perdanakusuma Department of Plastic Reconstructive and Aesthetic Surgery, Dr. Soetomo General Academic Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia
Setyawati Soeharto Department of Pharmacology, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia
Edi Widjajanto Department of Clinical Pathology, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia
Kusworini Handono Department of Clinical Pathology, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia
Bambang Pardjianto Plastic, Aesthetic and Reconstruction Surgery Consultant, Saiful Anwar General Hospital, Malang 65111, Indonesia; Faculty of Medicine and Health Sciences, State Islamic University of Malang, Malang 65144, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6002

Keywords:

Collagen density, Collagen deposition, Keloid, Melanin, Skin

Abstract

BACKGROUND: Keloid is a form of wound healing that results from fibrous tissue activity. It can develop beyond the boundaries of the original wound, extends into the dermis layer, and disrupting the appearance. Previously, no studies have revealed a correlation between melanin pigment and keloid.

AIM: This research aimed to describe the correlation between melanin concentration and collagen deposition in keloid tissue.

MATERIALS AND METHODS: A prospective study conducted through the application of a cross-sectional analytic survey method. The color of the skin was measured using a chromameter, and a histopathologic examination was performed on the skin surrounding the keloid, as well as the keloid tissue. Data were analyzed using a t-test, correlation, and linear regression statistics.

RESULTS: The results showed a significant difference between melanin concentration and collagen deposition in the skin surrounding the keloid tissue. No significant difference was observed between melanin concentration in the surrounding skin of keloid and those in the keloid tissue, as well as collagen deposition. Meanwhile, the melanin concentration in the surrounding skin of keloid and keloid tissue had a significant relationship with fibrocytes number.

CONCLUSION: There is a significant correlation between melanin concentrations and collagen density in the keloid tissue.

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