Coenzyme Q10 Supplementation as an Adjuvant Therapy Potentially Increase Serum Superoxide Dismutase Levels in Acne Vulgaris Patients

Carissa Adriana; Asih Budiastuti; Kabulrachman Kabulrachman; Retno Indar Widayati; Puguh Riyanto; Muslimin Muslimin

doi:10.3889/oamjms.2021.6048

Authors

Carissa Adriana Department of Dermatovenereology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia https://orcid.org/0000-0002-2322-3595
Asih Budiastuti Department of Dermatovenereology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
Kabulrachman Kabulrachman Department of Dermatovenereology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
Retno Indar Widayati Department of Dermatovenereology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
Puguh Riyanto Department of Dermatovenereology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
Muslimin Muslimin Department of Dermatovenereology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6048

Keywords:

Acne vulgaris, Coenzyme Q10, Oxidative stress, Superoxide dismutase, Tretinoin

Abstract

BACKGROUND: Acne vulgaris (AV) is a chronic inflammatory disease in the pilosebaceous unit. Recent research has begun to focus on the essential relationship between oxidative stress and the pathogenesis of AV. The use of antioxidants like coenzyme Q10 (CoQ10) that has various advantages as adjuvant therapy is expected to be beneficial for AV.

AIM: The study was aimed to analyze the effect of CoQ10 supplementation on serum SOD levels and the severity of AV patients.

METHODS: A double blind-randomized controlled trial was carried out on 36 patients with AV and classified according to severity degree of AV. These patients were randomly divided into two groups (treatment group with tretinoin 0.025% cream and once-daily supplementation of CoQ10 100 mg tablet; and placebo group with tretinoin 0.025% cream and once-daily placebo tablet). Response to treatment was based on serum superoxide dismutase (SOD) level and AV severity degree.

RESULTS: Administration of CoQ10 to AV patients significantly increase serum SOD level (p = 0.008) and improves the severity of AV after 8 weeks (p = 0.008).

CONCLUSION: CoQ10 supplementation can increase serum SOD levels and improve the severity of AV.

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References

Gaber MA, Dawood AA, Mahmoud AA. Oxidants and antioxidants role in acne vulgaris. Menoufia Med J. 2014;27:465-8. https:// doi.org/10.4103/1110-2098.141728 DOI: https://doi.org/10.4103/1110-2098.141728

Mills OH, Criscito MC, Schlesinger TE, Verdicchio R, Szoke E. Addressing free radical oxidation in acne vulgaris. J Clin Aesthet Dermatol. 2016;9(1):25-30. PMid:26962389

El Garem YF, Ahmed RA, Ragab MA, AbouZeid AA. Study of oxidative stress in different clinical severities of acne vulgaris. Egypt J Dermatol Venerol. 2014;34:53-7. https://doi.org/10.4103/1110-6530.137313 DOI: https://doi.org/10.4103/1110-6530.137313

Tangheti EA. The role of inflammation in the pathology of acne. J Clin Aesthet Dermatol. 2013;6(9):27-35. PMid:24062871

Marzano AV, Ortega-Loayza AG, Heath M, Morse D, Genovese G, Cugno M. Mechanisms of inflammation in neutrophil-mediated skin diseases. Front Immunol. 2019;10:1059. https://doi.org/10.3389/fimmu.2019.01059 PMid:31139187 DOI: https://doi.org/10.3389/fimmu.2019.01059

Kardeh S, Moein SA, Namazi MR, Kardeh B. Evidence for the important role of oxidative stress in the pathogenesis of acne. GMJ. 2019;8:e1291. DOI: https://doi.org/10.31661/gmj.v8i0.1291

Zouboulis CC, Bettoli V. Management of severe acne. Br J Dermatol. 2015;172(S1):27. https://doi.org/10.1111/bjd.13639. PMid:25597508 DOI: https://doi.org/10.1111/bjd.13639

Cong T, Hao D, Wen X, Li XH, He G, Jiang X. From pathogenesis of acne vulgaris to anti acne agents. Arch Dermatol Res. 2019;311(5):337-49. https://doi.org/10.1007/s00403-019-01908-x PMid:30859308 DOI: https://doi.org/10.1007/s00403-019-01908-x

Baumann L, Saghari S. Antioksidan. In: Baumann L, Saghari S, Weisberg E, editors. Cosmetic Dermatology. 2nd ed. New York: McGraw-Hill; 2009.

Baek J, Lee MG. Oxidative stress and antioxidant strategies in dermatology. Redox Rep. 2016;21(4):164-9. https://doi.org/10.1179/1351000215y.0000000015 PMid:26020527 DOI: https://doi.org/10.1179/1351000215Y.0000000015

Rinnerthaler M, Bischof J, Streubel MK, Trost A, Richter K. Oxidative stress in aging human skin. Biomolecules. 2015;5(2):545-89. https://dx.doi.org/10.3390%2Fbiom5020545 PMid:25906193 DOI: https://doi.org/10.3390/biom5020545

Mirończuk-Chodakowska I, Witkowska AM, Zujko ME. Endogenous non-enzymatic antioxidants in the human body. Adv Med Sci. 2018;63(1):68-78. https://doi.org/10.1016/j.advms.2017.05.005 PMid: 28822266 DOI: https://doi.org/10.1016/j.advms.2017.05.005

Kelompok Studi Dermatologi Kosmetik Indonesia. Indonesian Acne Expert Meeting 2015. Jakarta: Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia; 2015.

Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74:945-73. https://doi.org/10.1016/j.jaad.2015.12.037 PMid:26897386 DOI: https://doi.org/10.1016/j.jaad.2015.12.037

Bowe WP, Logan AC. Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles. Lipids Health Dis. 2010;9:141. https://dx.doi.org/10.1186%2F1476-511X-9-141 PMid:21143923 DOI: https://doi.org/10.1186/1476-511X-9-141

Vollmer DL, West VA, Lephart ED. Enhancing skin health: By oral administration of natural compounds and minerals with implications to the dermal microbiome. Int J Mol Sci. 2018;19(10):E3059. https://dx.doi.org/10.3390%2Fijms19103059 PMid:30301271 DOI: https://doi.org/10.3390/ijms19103059

Sahib AS, Al-Anbari HH, Raghif AR. Oxidative stress in acne vulgaris: An important therapeutic target. J Mol Pathophysiol. 2013;2:27-31. https://doi.org/10.5455/jmp.20130127102901 DOI: https://doi.org/10.5455/jmp.20130127102901

Varela-López A, Giampieri F, Battino M, Quiles JL. Coenzyme Q and its role in dietary therapy against aging. Molecules. 2016;21:373. https://dx.doi.org/10.3390%2Fmolecules21030373 PMid:26999099 DOI: https://doi.org/10.3390/molecules21030373

Le Quéré S, Lemaire B, Carillon J, Schmitt K. The role of superoxide dismutase (SOD) in skin disorders. A review. Nutrafoods. 2014;13:13-27. https://doi.org/10.1007/ s13749-014-0001-x

Zhai J, BoY, Lu Y, Liu C, Zhai L. Effects of coenzyme q10 on markers of inflammation: A systematic review and meta-analysis. PLoS One. 2017;12(1):170-2. https://doi.org/10.1371/journal.pone.0170172 PMid:28125601 DOI: https://doi.org/10.1371/journal.pone.0170172

Turunen M, Olsson J, Dallner G. Metabolism and function of coenzyme Q. Biochim Biophys Acta 2004;1660(1-2):171-99. https://doi.org/10.1016/j.bbamem.2003.11.012 PMid:14757233 DOI: https://doi.org/10.1016/j.bbamem.2003.11.012

Kagan VE, Quinn PJ. Coenzyme Q: Molecular Mechanism in Health and Disease. New York: CRC Press; 2000. DOI: https://doi.org/10.1201/9781420036701

Maria T. Alternative Medicine and Control Over the Oxidative Stress. Maldova: Lambert Publishing; 2018.

Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, et al.Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol. 2002;169(3):1535-41. https://dx.doi.org/10.4049%2Fjimmunol.169.3.1535 PMid:12133981 DOI: https://doi.org/10.4049/jimmunol.169.3.1535

Dispenza MC, Wolpert EB, Gilliland KL, Dai JP, Cong Z, Nelson AM, et al. Systemicisotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients. J Invest Dermatol. 2012;132(9):2198-205. https://doi.org/10.1038/jid.2012.111 PMid:22513780 DOI: https://doi.org/10.1038/jid.2012.111

Grange AP, Chéreau C, Raingeaud J, Nicco C, Weill B, Dupin N, et al. Production of superoxide anions by keratinocytes initiates P. acnes-induced inflammation of the skin. PLoS Pathog. 2009;5(7):e1000527. https://doi.org/10.1371/journal.ppat.1000527 PMid:19629174 DOI: https://doi.org/10.1371/journal.ppat.1000527

Wasitaatmadja SM. Akne, erupsi akneiformis, rosasea, rinofima. [Acne, eruption acneiformis, rosacea, rhinophyma]. In: Djuanda A, Hamzah M, Aisah S, editors. Ilmu Penyakit Kulit Dan Kelamin. Dermatology and Venereology. Jakarta: Faculty of Medical, University of Indonesia; 2010.

Jorat MV, Tabrizi R, Kolahdooz, Akbari M, Salami M, Heydari ST, et al. The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: A systematic review and meta-analysis of randomized controlled trials. Inflammopharmacol. 2019;27:233–48. https://doi.org/10.1007/s10787-019-00572-x PMid:30758695 DOI: https://doi.org/10.1007/s10787-019-00572-x

Zhang M, Dang L, Guo F, Wang X, Zhao W, Zhao R. Coenzyme Q(10) enhances dermal elastin expression, inhibits IL-1α production and melanin synthesis in vitro. Int J Cosmetic Sci. 2012;34(3):273-9. https://doi.org/10.1111/j.1468-2494.2012.00713.x PMid:22339577 DOI: https://doi.org/10.1111/j.1468-2494.2012.00713.x

Szmurło A, Kucharska A. Significance of diet and oral supplementation in acne vulgaris. EMJ Dermatol. 2016;4(1):90- 4. https://dx.doi.org/10.5114%2Fada.2016.59146 PMid:27279815

Addor FAS. Antioxidants in dermatology. Ana Brasil Dermatol. 2017;92(3):356-62. https://doi.org/10.1590/abd1806-4841.20175697 PMid:29186248 DOI: https://doi.org/10.1590/abd1806-4841.20175697

Leyden J, Stein-Gold L, Weiss J. Why topical retinoids are mainstay of therapy for acne. Dermatol Ther. 2017;7(3):293-304. https://dx.doi.org/10.1007%2Fs13555-017-0185-2 PMid:28585191 DOI: https://doi.org/10.1007/s13555-017-0185-2

Perihan O, Ergul KB, Neslihan D, Filiz A. The activity of adenosine deaminase and oxidative stress biomarkers in scraping samples of acne lesions. J Cosmetic Dermatol. 2012;11(4):323-8. https://doi.org/11.10.1111/jocd.12011. DOI: https://doi.org/10.1111/jocd.12011

Al-Shobaili HA, Alzolibani AA, Al Robaee AA, Meki AR, Rasheed Z. Biochemical markers of oxidative and nitrosative stress in acne vulgaris: Correlation with disease activity. Ann Clin Lab Sci. 2013;27(1):45-52. https://dx.doi.org/10.1002%2Fjcla.21560 PMid:23325743 DOI: https://doi.org/10.1002/jcla.21560