Clinical Profiles, Demographic Features, and Maternal Outcomes among Coronavirus Disease Positive Pregnant Women: A Cross-sectional Study


  • Zaheera Saadia Department of Obstetrics and Gynecology, Qassim University, Almulida, Al-Qassim, Saudi Arabia
  • Robina Farrukh Department of Obstetrics and Gynecology, Sir Ganga Ram Hospital, Lahore, Punjab, Pakistan
  • Sumaira Kanwal Department of Obstetrics and Gynecology, Sir Ganga Ram Hospital, Lahore, Punjab, Pakistan
  • Quratulain Shahzad Department of Obstetrics and Gynecology, Sir Ganga Ram Hospital, Lahore, Punjab, Pakistan image/svg+xml



Pregnant women, Coronavirus disease 2019, Neonates


BACKGROUND: Pregnant women are susceptible to coronavirus infection due to physiological changes in the circulatory and immunological parameters.

AIM: The current study aimed to determine the demographic factors, clinical symptoms, and fetal-maternal outcomes and also compare the blood parameters and chest X-ray results among coronavirus disease 2019 (COVID-19) positive and negative pregnant women.

MATERIALS AND METHODS: Complete blood count and Chest X-rays were performed as a routine in all pregnant women. Polymerase chain reaction for COVID-19 was performed for all women and the newborn.

RESULTS: The blood parameters revealed that a significantly greater proportion of COVID-19 positive pregnant women had abnormal hemoglobin, total leukocyte count, neutrophil count, lymphocyte count, monocyte count, bilirubin, aspartate aminotransferase, alanine aminotransferase, and urea.

CONCLUSIONS: The present study provided crucial insights into epidemiological and clinical features during the perinatal period. Chest X-rays and blood routine examination are reliable findings to prevent COVID-19 complications among pregnant women.


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World Health Organization. Coronavirus Disease 2019 (COVID-19): Situation Report. Geneva: World Health Organization; 2020. p. 60.

Schwartz DA. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: Maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med. 2020;144(7):799-805. PMid:32180426

Arbabzadeh T, Noori N, Najafian A, Ghasemi M. Assessment of corona in pregnant women: Epidemiology, clinical signs, prevention and treatment. J Complement Med Res. 2020;11(3):118-30.

Ellington S, Strid P, Tong VT, Woodworth K, Galang RR, Zambrano LD, et al. Characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status-United States, January 22-June 7, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(25):769. PMid:32584795

Badr DA, Mattern J, Carlin A, Cordier AG, Maillart E, El Hachem L, et al. Are clinical outcomes worse for pregnant women at≥ 20 weeks’ gestation infected with coronavirus disease 2019? A multicenter case-control study with propensity score matching. Am J Obstet Gynecol. 2020;223(5):764-8. PMid:32730899

Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: A retrospective, single-centre, descriptive study. Lancet Infect Dis. 2020;20(5):559-64.

Anand P, Yadav A, Debata P, Bachani S, Gupta N, Gera R. Clinical profile, viral load, management and outcome of neonates born to COVID 19 positive mothers: A tertiary care centre experience from India. Eur J Pediatr. 2020;180(2):547-59. PMid:32910210

Centers for Disease Control and Prevention. Centers for Disease Control and Prevention Coronavirus Disease 2019 (COVID-19) 2020. United States: Centers for Disease Control and Prevention; 2020.

Government of Pakistan. Sexual Reproductive and Maternal Health Services during COVID-19. 2020. Available from:

Panahi L, Amiri M, Pouy S. Risks of novel coronavirus disease (COVID-19) in pregnancy; a narrative review. Arch Acad Emerg Med. 2020;8(1):e34. PMid:32232217

Perrone S, Deolmi M, Giordano M, D’Alvano T, Gambini L, Corradi M, et al. Report of a series of healthy term newborns from convalescent mothers with COVID-19. Acta Biomed. 2020;91(2):251. PMid:32420961

Sahin D, Tanacan A, Erol SA, Anuk AT, Yetiskin FD, Keskin HL, et al. Updated experience of a tertiary pandemic center on 533 pregnant women with COVID-19 infection: A prospective cohort study from Turkey. Int J Gynaecol Obstet. 2021;152(3):328-34.

Yang H, Sun G, Tang F, Peng M, Gao Y, Peng J, et al. Clinical features and outcomes of pregnant women suspected of coronavirus disease 2019. J Infect. 2020;81(1):e40-4.

Ashraf MA, Keshavarz P, Hosseinpour P, Erfani A, Roshanshad A, Pourdast A, et al. Coronavirus disease 2019 (COVID-19): A systematic review of pregnancy and the possibility of vertical transmission. J Reprod Infertil. 2020;21(3):157-68. PMid:32685412

Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020;99(7):823-9. PMid:32259279

Tanacan A, Erol SA, Turgay B, Anuk AT, Secen EI, Yegin GF, et al. The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: Experience of a pandemic center in Turkey. Eur J Obstet Gynecol Reprod Biol. 2020;253:31-4. PMid:32763728

Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, et al. Clinical and immunologic features in severe and moderate forms of coronavirus disease. J Clin Invest. 2019;130(5):2620-9. PMid:32217835

Wang C, Deng R, Gou L, Fu Z, Zhang X, Shao F, et al. Preliminary study to identify severe from moderate cases of COVID-19 using combined hematology parameters. Ann Transl Med. 2020;8(9):593. PMid:32566620

Turan O, Hakim A, Dashraath P, Jeslyn WJ, Wright A, Abdul-Kadir R. Clinical characteristics, prognostic factors, and maternal and neonatal outcomes of SARS-CoV-2 infection among hospitalized pregnant women: A systematic review. Int J Gynecol Obstet. 2020;151(1):7-16. PMid:32816307

Zeng L, Xia S, Yuan W, Yan K, Xiao F, Shao J. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA Ped. 2020;174(7):722-5. PMid:32215598

Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus disease 2019 (COVID-19) and pregnancy: What obstetricians need to know. Am J Obstetr Gynecol. 2020;222(5):415-26. PMid:32105680

Rasmussen SA, Kissin DM, Yeung LF, MacFarlane K, Chu SY, Turcios-Ruiz RM, et al. Preparing for influenza after 2009 H1N1: Special considerations for pregnant women and newborns. Am J Obstet Gynecol. 2011;204(6):S13-20. PMid:21333967

Mirzadeh M, Khedmat L. Pregnant women in the exposure to COVID-19 infection outbreak: The unseen risk factors and preventive healthcare patterns. J Matern Fetal Neonatal Med. 2009:1-2. PMid:32223477




How to Cite

Saadia Z, Farrukh R, Kanwal S, Shahzad Q. Clinical Profiles, Demographic Features, and Maternal Outcomes among Coronavirus Disease Positive Pregnant Women: A Cross-sectional Study. Open Access Maced J Med Sci [Internet]. 2021 Jun. 25 [cited 2021 Sep. 20];9(B):486-91. Available from:



Gynecology and Obstetrics