Polymorphism of Thyroid Hormones Receptor, Angiotensin-Converting Enzyme, and High Blood Pressure in Childbearing Age Women with Hyperthyroidism

Agus Wibowo; Pramudji  Hastuti; Vinayanti Susanti

doi:10.3889/oamjms.2021.6193

Authors

Agus Wibowo Student of Doctorate Program, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Jogjakarta, Yogyakarta, Indonesia; National Institute Health Research and Development, Indonesia Ministry of Health https://orcid.org/0000-0003-2176-2525
Pramudji Hastuti Department of Biochemistry Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Jogjakarta, Yogyakarta, Indonesia
Vinayanti Susanti Department of Internal Medicine Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada Jogjakarta, Yogyakarta, Indonesia https://orcid.org/0000-0002-4422-8088

DOI:

https://doi.org/10.3889/oamjms.2021.6193

Keywords:

Polymorphism, Blood pressure, Angiotensin-converting enzyme I/D, THRA, Renin-angiotensin system, Thyroid hormone, Hyperthyroidism

Abstract

AIM: This study aimed to investigate the association between two polymorphisms of thyroid hormone receptor and renin-angiotensin system (THRA C/T and angiotensin-converting enzyme (ACE) I/D) genes with hypertension in childbearing age women with hypertension.

METHODS: This was a case–control study including 35 cases and 40 matched control subjects. The case group was hyperthyroid women with hypertension while the control group was hyperthyroid women with normotension. The polymorphisms were identified by a classical polymerase chain reaction.

RESULTS: The THRA C/T gene and ACE I/D polymorphisms were not associated with the hypertension while the genotype frequencies in hyperthyroid women with hypertension were as follows: CC genotype was 25.71%, CT genotype was 54.29%, and TT genotype was 20.00%. The ACE I/D genotype frequencies in hyperthyroid women with hypertension were as follows: II genotype was 23.53%, whereas in hyperthyroid women without hypertension, the I/D genotype frequencies were CC: 7.50%, CT: 72.50%, and TT: 20.00%. There were no differences in age, thyroid-stimulating hormone, FT4, systolic blood pressure (SBP), diastolic BP between subgroups in ACE I/D, and at THRA rs-939348. There was a significant difference in the levels of FT4 concentrations in THRA rs-939348. Hypertension groups have higher SBP than controls. Genotype II had higher SBP but it was not statistically significant, while individuals with allele I had SBP higher than D allele.

CONCLUSIONS: The I allele of the ACE gene is involved in susceptibility to hypertension and polymorphism in THRA increasing concentration of FT4. There was no statistically significant difference in blood pressure between hyperthyroid women with or without hypertension.

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Author Biography

Vinayanti Susanti, Department of Internal Medicine Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada Jogjakarta, Yogyakarta, Indonesia

Departement Of Internal Medicine FKKMK UGM, and Sardjito Hospital

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