Clinical Signs and Laboratory Parameters as Predictors of Mortality among Hospitalized Human Immunodeficiency Virus-Infected Adult Patients at Tertiary Hospital in Surabaya


  • Rentha Monica Simamora Department of Internal Medicine, Faculty of Medicine, Airlangga University, Soetomo General Teaching Hospital, Surabaya, Indonesia; Department of Internal Medicine, Dr. Kanudjoso Djatiwibowo General Hospital, Balikpapan, Indonesia
  • Muhammad Vitanata Arfijanto Department of Internal Medicine, Faculty of Medicine, Airlangga University, Soetomo General Teaching Hospital, Surabaya, Indonesia
  • Musofa Rusli Department of Internal Medicine, Faculty of Medicine, Airlangga University, Soetomo General Teaching Hospital, Surabaya, Indonesia
  • Budi Utomo Department of Public Health and Preventive Medicine, Faculty of Medicine, Airlangga University, Surabaya, Indonesia
  • Cennikon Pakpahan Department of Biomedical Sciences, Andrology Study Program, Faculty of Medicine, Airlangga University, Surabaya, Indonesia
  • Mr. Garry Prasetyo Adi



Predictors, Morbidity, Mortality, Human Immunodeficiency Virus/AIDS, Clinical sign, Laboratory parameters


BACKGROUND: The morbidity and mortality rates due to human immunodeficiency virus (HIV) infection are still high despite various and advanced efforts in the management given for HIV/AIDS patients.

AIM: This study proposed that clinical signs and laboratory parameters could be expected to predict the patient’s mortality.

METHODS: This retrospective study was done by collecting 408 medical records of adult HIV/AIDS inpatients at a tertiary hospital in Surabaya from January 1, 2017, to December 31, 2019. Bivariate analysis using Chi-square test was carried out on nine variables, which were Glasgow Coma Scale (GCS) <15, hypotension, PaO2/FiO2 <400 mmHg, elevated liver enzymes, hemoglobin levels <10 mg/dl, platelet count <150,000/mm3, eGFR <60 ml/min/1.73 m2, albumin levels <3.5 mg/dl, and body mass index (BMI) <18.5 kg/m2. Variables which met the criteria would be included in the multivariate analysis using logistic regression.

RESULTS: Based on bivariate analysis, mortality was found to be significantly associated with GCS <15, hypotension, PaO2/FiO2, elevated liver enzymes, platelet count <100,000 mm3, eGFR <60 ml/1.73kg/m2, albumin levels <3.5 mgdl, and BMI <18.5 kg/m2. However, based on multivariate analysis, there were five variables which were found to be able to independently predict the patients’ mortality, those were GCS <15 (OR 11.625), hypotension (OR 6.062), PaO2/FiO2< 400 mmHg (OR 7.794), eGFR <60 ml/min/1.73 m2 (OR 2.646), and albumin levels <3.5 mg/dl (OR 4.091).

CONCLUSION: GCS <15, hypotension, PaO2/FiO2 <400 mmHg, eGFR <60 ml/1.73g/m2, and albumin levels <3.5 mg/dl were found as the independent risk factors which could predict the hospitalized HIV/AIDS patients’ mortality.


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Author Biography

Mr. Garry Prasetyo Adi

Department of Internal Medicine, Faculty of Medicine – Soetomo General Teaching Hospital, Airlangga University, Surabaya, Indonesia


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How to Cite

Monica Simamora R, Arfijanto MV, Rusli M, Utomo B, Pakpahan C, Adi GP. Clinical Signs and Laboratory Parameters as Predictors of Mortality among Hospitalized Human Immunodeficiency Virus-Infected Adult Patients at Tertiary Hospital in Surabaya. Open Access Maced J Med Sci [Internet]. 2021 Jun. 25 [cited 2024 Apr. 23];9(B):497-502. Available from:



Infective Diseases


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