Maternal Death Caused by Severe-Critical COVID-19 in Jakarta: Case Series
Case Series
DOI:
https://doi.org/10.3889/oamjms.2021.6250Keywords:
COVID-19, Maternal Death, Indonesia, Case SeriesAbstract
BACKGROUND: As of January 2021, Indonesia had the 21st highest number of total COVID-19 cases and the 17th highest total deaths among all countries. COVID-19 infection in pregnant women seems to negatively affect both maternal and neonatal outcomes.
CASE REPORT: We describe four cases of pregnant women confirmed with severe and critical COVID-19 that resulted in maternal death from November until December 2020. The first case was complicated with thrombocytopenia, her condition quickly deteriorated post-delivery. Pulmonary embolism was suspected as the cause of death. Second and third cases were complicated with preeclampsia, obesity, and advanced maternal age. Second case came in sepsis condition. Her SARS CoV-2 RTPCR swab test came out after her death. Third patient did not have COVID-19 symptoms at admission. She starts having symptoms on second day and was confirmed positive a day after. She falls in septic shock. Fourth patient has history of fever, cough, and dyspnea. She was confirmed positive on first day and her condition worsened, diagnosed with bacterial co-infection sepsis on day eight. All patients underwent cesarean section.
CONCLUSION: Limited information and studies for COVID-19 management in pregnant women are challenging for obstetricians. Management should be individualized weighing the benefit and risks in presence of comorbidities or accompanying disease.Downloads
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World Health Organisation. WHO Director-General’s Opening Remarks at the Media Briefing on COVID-19-11 March 2020. Geneva: World Health Organisation; 2020. Available from: https://www.who.int/director-general/speeches/detail/whodirector-general-s-opening-remarks-at-the-media-briefing-oncovid-19---11-march-2020. [Last accessed on 2021 Jan 12]. https://doi.org/10.1093/ww/9780199540884.013.u23682
World Health Organization. WHO Coronavirus Disease (COVID-19) Dashboard. Geneva: World Health Organisation; 2021. Available from: https://www.covid19.who.int/table. [Last accessed on 2021 Jan 12].
Di Guardo FD, Di Grazia FM, Di Gregorio LM, Zambrotta E, Carrara G, Gulino FA, et al. Poor maternal-neonatal outcomes in pregnant patients with confirmed SARSCov2 infection: analysis of 145 cases. Arch Gynecol Obstet. 2021;3:1-6. https://doi.org/10.1007/s00404-020-05909-4 DOI: https://doi.org/10.1007/s00404-020-05909-4
World Health Organization. Corticosteroids for COVID-19. Geneva: World Health Organization; 2021. Available from: https://www.apps.who.int/iris/rest/bitstreams/1299344/retrieve. [Last accessed on 2021 Jan 14].
Takemoto ML, Menezes MO, Andreucci CB, Knobel R, Sousa L, Katz L, et al. Clinical characteristics and risk factors for mortality in obstetric patients with severe COVID-19 in Brazil: A surveillance database analysis. BJOG. 2020;127:1618-26. https://doi.org/10.1111/1471-0528.16470 DOI: https://doi.org/10.1111/1471-0528.16470
Royal College of Obstetricians and Gynaecologists, Coronavirus (COVID-19) Infection in Pregnancy; 2021. Available from: https://www.rcog.org.uk/globalassets/documents/guidelines/2020-10-14-coronavirus-covid-19-infection-in-pregnancy-v12.pdf. [Last accessed on 2021 Jan 14].
Centers for Disease Control and Prevention, Information for Clinicians on Investigational Therapeutics for Patients with COVID-19. Available from: https://www.cdc.gov/coronavirus/2019-ncov/hcp/therapeutic-options.html. [Last accessed on 2021 Jan 14].
Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, et al. Dexamethasone in hospitalized patients with Covid-19 preliminary report. N Engl J Med 2020;384(8):693-704. PMid:32678530
Xu P, Zhou Q, Xu J. Mechanism of thrombocytopenia in COVID-19 patients. Ann Hematol. 2020;99(6):1205-8. https://doi.org/10.1007/s00277-020-04019-0 PMid:32296910 DOI: https://doi.org/10.1007/s00277-020-04019-0
Zalpour A, Hanzelka K, Patlan JT, Rozner MA, Yusuf SW. Saddle pulmonary embolism in a cancer patient with thrombocytopenia: A treatment dilemma. Cardiol Res Pract. 2011;2011:835750. https://doi.org/10.4061/2011/835750 PMid:21234423 DOI: https://doi.org/10.4061/2011/835750
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet 2020;395(10229):1054-62. https://doi.org/10.1016/s0140-6736(20)30566-3 PMid:32171076 DOI: https://doi.org/10.1016/S0140-6736(20)30566-3
Titaley CR, Hunter CL, Heywood P, Dibley MJ. Why don’t some women attend antenatal and postnatal care services? A qualitative study of community members’ perspectives in Garut, Sukabumi and Ciamis districts of West Java Province, Indonesia. BMC Pregnancy Childbirth. 2010;10:61. https://doi.org/10.1186/1471-2393-10-61 DOI: https://doi.org/10.1186/1471-2393-10-61
Van der Weerd K, Dik WA, Schrijver N, Schewitzer DH, Langerak AW, Drexhage HA, et al. Morbidly obese human subjects have increased peripheral blood CD4+ T cells with skewing toward a treg-and Th2-dominated phenotype. Diabetes. 2012;61(2):401-8. https://doi.org/10.2337/db11-1065 PMid:22228716 DOI: https://doi.org/10.2337/db11-1065
Popkin BM, Du S, Green WD, Beck MA, Algaith T, Herbst CH, et al. Individuals with obesity and COVID-19: A global perspective on the epidemiology and biological relationships. Obes Rev. 2020;21(11):e13128. https://doi.org/10.1111/obr.13128 PMid:32845580 DOI: https://doi.org/10.1111/obr.13128
Lansbury L, Lim B, Baskaran V, Lim WS. Co-infections in people with COVID-19: A systematic review and meta-analysis. J Infect. 2020;81(2):266-75. https://doi.org/10.1016/j.jinf.2020.05.046 PMid:32473235 DOI: https://doi.org/10.1016/j.jinf.2020.05.046
National Centre for Infectious Diseases. Interim Treatment Guidelines for COVID-19. Available from: https://www.ncid.sg/Documents/Interim%20Treatment%20Guidelines%20for%20COVID-19%20v4%20%2831%20Aug%202020%29-%20final.docx%20for%20upload.pdf, 2021. [Last accessed on 2021 Jan 19].
Burwick RM, Yawetz S, Stephenson KE, Collier AR, Sen P, Blackburn BG, et al. Compassionate Use of remdesivir in pregnant women with severe Covid-19. Clin Infect Dis. 2020;8:ciaa1466. PMid:33031500
Saad AF, Chappell L, Saade GR, Pacheco LD. Corticosteroids in the management of pregnant patients with coronavirus disease (COVID-19). Obstet Gynecol. 2020;136(4):823-6. https://doi.org/10.1097/aog.0000000000004103 PMid:32769659 DOI: https://doi.org/10.1097/AOG.0000000000004103
Constanzo G, Firinu D, Losa F, Deidda M, Barca MP, Del Giacco S. Baricitinib exposure during pregnancy in rheumatoid arthritis. Ther Adv Musculoskel Dis. 2020;12:1-3. https://doi.org/10.1177/1759720x19899296 PMid:32071617 DOI: https://doi.org/10.1177/1759720X19899296
Fenizia C, Biasin M, Cetin I, Vergani P, Mileto D, Spinillo A, et al. Analysis of SARS-CoV-2 vertical transmission during pregnancy. Nat Commun. 2020;11(1):5128. https://doi.org/10.1038/s41467-020-18933-4 PMid:33046695 DOI: https://doi.org/10.1038/s41467-020-18933-4
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Copyright (c) 2021 Suskhan Djusad, Alfa Putri Meutia, Arresta Suastika, Gita Nurul Hidayah, Ilham Utama Surya, Muhammad Priangga, Raden Fadhly, Achmad Kemal Harzif (Author)
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