The Relationship between Brain-derived Neurotrophic Factor’s Serum Level and Hospital Anxiety and Depression Scale-depression in Patients with Psoriasis Vulgaris

Authors

  • Elmeida Efffendy Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Muhammad Sjahrir Department of Dermato-Venerology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Nurul Utami Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6290

Keywords:

Psoriasis vulgaris, Brain-derived neurotrophic factor’s serum level, Hospital anxiety and depression scale-depression

Abstract

BACKGROUND: Psoriasis vulgaris is a chronic inflammatory skin disorder that can lead to depression. The involvement of the nervous system in psoriasis was proved by the influence of brain-derived neurotrophic factor (BDNF) in regulating corneocyte homeostasis. Low level of BDNF in patients with psoriasis result in transit amplifying subpopulation of basal keratinocytes not performing their function as inhibitors of keratinocyte proliferation, resulting in acceleration of keratinocyte proliferation. In depressed patients, it is known that levels of BDNF in the serum and hippocampus are low. BDNF level imbalance potentially affects the severity of psoriasis and depression.

METHODS: This is an analytical cross-sectional study. The measurement of BDNFs serum level was carried out in the Medan Private Laboratory using a human BDNF (R and D®, USA) kit using the ELISA method. We use hospital anxiety and depression scale (HADS-D) questionnaire to assess depression symptoms.

RESULTS: The results of the Spearman correlation test for BDNFs serum level and HADS-D showed p < 0.05, it can be concluded that there is a correlation between BDNFs serum level and HADS-D. The strength of the relationship between HADS-D and BDNFs serum level is −0.537 that shows moderate correlation (r = 0.4 −<0.6). Relationship between HADS-D and BDNFs serum level is −0.537 that shows moderate correlation (r = 0.4 −<0.6).

CONCLUSION: This study shows a moderate negative relationship between BDNFs serum level and the degree of symptoms of depression, which the lower level of BDNFs serum will increase the degree of depression symptoms.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Gudjonsson JE, Elder JT. Psoriasis. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick’s Dermatology in General Medicine. 8th ed. New York: Mcgraw Hill Companies; 2012. p. 197-231. https://doi.org/10.1111/j.1524-4725.2008.34211.x

Brunoni AR, Lotufo PA, Sabbag C, Goulart AC, Santos IS, Bensenor IM. Decreased brain-derived neurotrophic factor plasma levels in psoriasis patients. Braz J Med Biol Res. 2015;48(8):711-4. https://doi.org/10.1590/1414-431x20154574 PMid:26200230

Karege F, Perret G, Bondolfi G. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res. 2002;109(2):143-8. https://doi.org/10.1016/s0165-1781(02)00005-7 PMid:11927139

Sen S, Duman R, Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: Meta-analyses and implications. Biol Psychiatry. 2008;64(6):527-32. https://doi.org/10.1016/j.biopsych.2008.05.005 PMid:18571629

Fry L. An Atlas of Psoriasis. Carnforth: Parthenon Publishing; 1992.

Meffert J. Psoriasis. USA; 2015. Available from: http://www.emedicine.medscape.com/article/943419-overview. [Last accessed on 2016 July 03].

Schmitt J, Ford DE. Understanding the relationship between obejctive disease severity, psoriatic symptoms, illness-related stress, health-related quality of life and depressive symptoms in patients with psoriasis a structural equations modeling approach. Gen Hosp Psychiatry. 2007;29(2):134-40. https://doi.org/10.1016/j.genhosppsych.2006.12.004 PMid:17336662

Dowlatshahi EA, Wakkee M, Arends LR, Nijsten T. The prevalence and odds of depressive symptoms and clinical depression in psoriasis patients: A systemic review and meta-analysis. J Investig Dermatol. 2014;134(6):1542-51. https://doi. org/10.1038/jid.2013.508 PMid:24284419

Fortune DG. Psychologic factors in psoriasis: Consequences, mechanisms, and interventions. Dermatol Clin. 2005;23(4):681-94. PMid:16112445

Cooper-Patrick L, Crum RM, Ford DE. Identifying suicidal ideation in general medical patients. JAMA. 1994;272(22):1757-62. https://doi.org/10.1001/jama.1994.03520220051030 PMid:7966924

Narbutt J, Olejniczak I, Sztychny SD, Jedrzejowska SA, Kwiatkowska SI, Hawro T, et al. Narrow band ultraviolet B irradiations cause alteration in interleukin-31 serum level in psoriatic patients. Arch Dermatol Res. 2013;305(3):191-5. https://doi.org/10.1007/s00403-012-1293-6 PMid:23108364

Bath KG, Schilit A, Lee FS. Stress effects on BDNF expression: Effects of age, sex, and form of stress. Neuroscience. 2013;239:149-56. https://doi.org/10.1016/j.neuroscience.2013.01.074 PMid:23402850

Fatty H, Tawfik AA, Madbouly N. Evaluation of serum brain-derived neurotrophic factor in assessing the association between psoriasis and depression. J Egypt Women Dermatol. 2015;12:186-90.

Korkoliakou P, Christodoulou C, Kouris A, Porsche E, Efstathiou V, Kaloudi E, et al. Alexithymia, anxiety and depression in patients with psoriasis: A case-control study. Ann Gen Psychiatry. 2014;13(1):38. https://doi.org/10.1186/s12991-014-0038-7 PMid:25520742

Yu H, Chen Z. The role of BDNF in depression based on its location in theneural circuitry. Acta Pharmacol. 2011;32(1):3-11. PMid:21131999

Downloads

Published

2021-05-20

How to Cite

1.
Efffendy E, Sjahrir M, Utami N. The Relationship between Brain-derived Neurotrophic Factor’s Serum Level and Hospital Anxiety and Depression Scale-depression in Patients with Psoriasis Vulgaris. Open Access Maced J Med Sci [Internet]. 2021 May 20 [cited 2024 Apr. 21];9(T3):164-7. Available from: https://oamjms.eu/index.php/mjms/article/view/6290

Most read articles by the same author(s)

1 2 > >>