Cytokine Level and Symptoms of Schizophrenia


  • Mustafa Mahmud Amin Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Elmeida Effendy Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia



Cytokines, Tumor necrosis factor-alpha, Schizophrenia


BACKGROUND: The study was intended to find one of the cytokines, that is, tumor necrosis factor (TNF)-alpha correlation with PANSS scores of people with schizophrenia (PwS) and their differences compared to the healthy people of Malayan- Mongoloid Race.

AIM: The aim of this study was providing a profile of TNF-alpha level in PwS of Malayan-Mongoloid race and its correlation with positive and negative symptoms in schizophrenia.

METHODS: It was conducted using cross-sectional and following sampling methods, with inclusion and exclusion criteria set for the PwS and control groups.

RESULTS: The result was no correlation between TNF-alpha levels with PANSS scores on PwS (p > 0.005), with very weak correlation and positive correlation direction, and there were differences in TNF-alpha levels.between PwS and control groups.

CONCLUSION: It can be concluded that the higher levels of TNF-alpha would impact on the severity symptoms experienced by PwS.


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How to Cite

Amin MM, Effendy E. Cytokine Level and Symptoms of Schizophrenia. Open Access Maced J Med Sci [Internet]. 2021 Jun. 14 [cited 2024 Jun. 17];9(T3):87-91. Available from:

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