The Effect of Coronavirus Disease 2019 on Reproduction System and Fertility


  • Muhammad Fidel Ganis Siregar Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Effinia Kamila Hanum Siregar Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia



COVID-19, pregnancy, fertility


As of October 9, 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was recorded to have infected more than 235 countries and 36,361,054 people globally, and 1,056,186 people died from coronavirus disease 2019 (COVID-19). In early October 2020, it was reported that the rate of increase in new cases reached 300,000 cases per day. A scientific reference source about COVID-19 in pregnancy and fertility system based on the results of previous research. By conducting a literature search that was carried out until October 12, 2020, through the PubMed and Google Scholar databases using the keyword COVID-19 and pregnancy, 20 articles were used as a reference source. Human SARS-CoV appeared in China, causing a deadly epidemic 18 years ago. Novel coronavirus-2019 infects target cells by binding to angiotensin-converting enzyme 2 (ACE2) through its surface spike protein. nCoV-2 modulates ACE2 expression and causes serious injury, similar to SARS-CoV. There is the possibility that the SARS-CoV-2 mechanism can affect fertility on female, namely, SARS-CoV-2 can harm ovarian tissue and granulosa cells, and reduce ovarian function and quality of oocytes, and can make infertility or miscarriage; also damage the endometrial epithelium and affect early embryo implantation. COVID-19 is caused by SARS-CoV-2 which is an acute infectious disease that mostly affects the respiratory system, but can also attack the reproductive system.


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How to Cite

Siregar MFG, Siregar EKH. The Effect of Coronavirus Disease 2019 on Reproduction System and Fertility. Open Access Maced J Med Sci [Internet]. 2021 Nov. 2 [cited 2023 Oct. 3];9(T3):362-8. Available from:

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