Salivary Alpha-amylase Enzyme and Salivary Cortisol Level in Depression after Treatment with Fluoxetine

Authors

  • Andi Jayalangkara Tanra Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia https://orcid.org/0000-0002-3962-4190
  • Hawaidah Madeali Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Mayamariska Sanusi Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Saidah Syamsuddin Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Sonny Teddy Lisal Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6347

Keywords:

Depression, Salivary alpha-amylase enzyme, Cortisol saliva, Fluoxetine

Abstract

Hypothalamic-Pituitary-Adrenal (HPA) axis and its end product cortisol have been extensively investigated in patients with depressive disorders for many years. Recently, salivary alpha-amylase (sAA) had emerged as a new biomarker with non-invasive and more convenience protocol for measuring sympathetic activity which were also associated with depression. Selective Serotonin Reuptake Inhibitor (SSRI) is antidepressant drug extensively used to treat depression. The aim of this study was to determine whether decrease of sAA and salivary cortisol levels could be observed in subjects with depression who were treated by fluoxetine. The total subjects were 25 depressed subjects and 10 healthy controls. sAA was examined before therapy, and after 2, 4 and 6 weeks of fluoxetine administration using a portable cocorometer. Salivary cortisol was examined before therapy, after 4 and 6 weeks of fluoxetine administration with Elisa method. The therapeutic effect was assessed with Hamilton Depression Rating Scale (HDRS). Results: sAA and cortisol level were significantly decreased after fluoxetine administration (p<0.001) followed by at least 50% reduction of HDRS scores after 6 weeks of fluoxetine administration. Levels of sAA and cortisol were higher in the depression group than in the healthy control. Conclusions: Measurement of sAA levels can be used as a potential biomarker of therapeutic response in depressed patients in addition to salivary cortisol.

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Published

2021-06-23

How to Cite

1.
Tanra AJ, Madeali H, Sanusi M, Syamsuddin S, Lisal ST. Salivary Alpha-amylase Enzyme and Salivary Cortisol Level in Depression after Treatment with Fluoxetine. Open Access Maced J Med Sci [Internet]. 2021 Jun. 23 [cited 2024 Nov. 12];9(T3):305-10. Available from: https://oamjms.eu/index.php/mjms/article/view/6347