Salivary Alpha-amylase Enzyme and Salivary Cortisol Level in Depression after Treatment with Fluoxetine
DOI:
https://doi.org/10.3889/oamjms.2021.6347Keywords:
Depression, Salivary alpha-amylase enzyme, Cortisol saliva, FluoxetineAbstract
Hypothalamic-Pituitary-Adrenal (HPA) axis and its end product cortisol have been extensively investigated in patients with depressive disorders for many years. Recently, salivary alpha-amylase (sAA) had emerged as a new biomarker with non-invasive and more convenience protocol for measuring sympathetic activity which were also associated with depression. Selective Serotonin Reuptake Inhibitor (SSRI) is antidepressant drug extensively used to treat depression. The aim of this study was to determine whether decrease of sAA and salivary cortisol levels could be observed in subjects with depression who were treated by fluoxetine. The total subjects were 25 depressed subjects and 10 healthy controls. sAA was examined before therapy, and after 2, 4 and 6 weeks of fluoxetine administration using a portable cocorometer. Salivary cortisol was examined before therapy, after 4 and 6 weeks of fluoxetine administration with Elisa method. The therapeutic effect was assessed with Hamilton Depression Rating Scale (HDRS). Results: sAA and cortisol level were significantly decreased after fluoxetine administration (p<0.001) followed by at least 50% reduction of HDRS scores after 6 weeks of fluoxetine administration. Levels of sAA and cortisol were higher in the depression group than in the healthy control. Conclusions: Measurement of sAA levels can be used as a potential biomarker of therapeutic response in depressed patients in addition to salivary cortisol.Downloads
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References
World Health Organization. Depression. Geneva: World Health Organization; 2018. Available from. https://www.who.int/news-room/fact-sheets/detail/depression. [Last accessed on 2018 Dec 10].
Indonesian Ministry of Health. Basic Health Research. Indonesia: Indonesian Ministry of Health; 2018. Available from: http://www.depkes.go.id/resources/download/info-terkini/materi_rakorpop_2018/Hasil%20Riskesdas%202018.pdf. [Last accessed on 2018 Dec 10]. https://doi.org/10.17501/24246735.2018.4105 DOI: https://doi.org/10.17501/24246735.2018.4105
Putra ST. Biology perception. In: Medical Psychoneuroimmunology. 2nd ed. Surabaya: Airlangga University Press; 2011. p. 33-41.
Won E, Kim Y. Stress, the autonomic nervous system, and the immune-kynurenine pathway in the etiology of depression. Curr Neuropharmacol. 2016;14(7):665-73. https://doi.org/10.2174/1570159x14666151208113006 PMid:27640517 DOI: https://doi.org/10.2174/1570159X14666151208113006
Ali N, Pruessner JC. The salivary alpha amylase over cortisol ratio as marker to assess dysregulations of the stress system. Physiol Behav. 2012;106(1):65-72. https://doi.org/10.1016/j.physbeh.2011.10.003 PMid:22019784 DOI: https://doi.org/10.1016/j.physbeh.2011.10.003
Sharpley CF. Neurobiological pathways between chronic stress and depression: Dysregulated adaptive mechanisms? Clin Med. 2009;2:33-45. DOI: https://doi.org/10.4137/CMPsy.S3658
Fried EI, Nesse RM. Depression sum-scores don’t add up: Why analyzing specific depression symptoms is essential. BMC Med. 2015;13(1):72. https://doi.org/10.1186/s12916-015-0325-4 DOI: https://doi.org/10.1186/s12916-015-0325-4
Hacimusalar Y, Eşel E. Suggested biomarker for major depressive disorder. Arch Neuropsychiatry. 2018;55(3):280-90. PMid:30224877 DOI: https://doi.org/10.29399/npa.19482
Chrousos GP. Stress and disorders of the stress system. Nat Rev Endocrinol. 2009;5(7):374-81. PMid:19488073 DOI: https://doi.org/10.1038/nrendo.2009.106
Booij SH, Bos EH, Bouwmans ME, Van Faassen M, Carr Kema LP, Oldehinkel AJ, et al. Cortisol and α-amylase secretion patterns between and within depressed and non-depressed individual. PLoS One. 2015;10(7):e0131002. https://doi.org/10.1371/journal.pone.0131002 PMid:26148294 DOI: https://doi.org/10.1371/journal.pone.0131002
Stetler C, Miller GE. Depression and hypothalamic-pituitary-adrenal activation: A quantitative summary of four decades of research. Psychosom Med. 2011;73(2):114-26. https://doi.org/10.1097/psy.0b013e31820ad12b PMid:21257974 DOI: https://doi.org/10.1097/PSY.0b013e31820ad12b
Schumacher S, Kirschbaum C, Fydrich T, Ströhle A. Is salivary alpha-amylase an indicator of autonomic nervous system dysregulations in mental disorders? A review of preliminary findings and the interactions with cortisol. Psychoneuroendocrinology. 2013;38(6):729-43. https://doi.org/10.1016/j.psyneuen.2013.02.003 PMid:23481259 DOI: https://doi.org/10.1016/j.psyneuen.2013.02.003
Ishitobi Y, Akiyoshi J, Tanaka Y, Ando T, Okamoto S, Kanehisa M, et al. Elevated salivary α-amylase and cortisol levels in unremitted and remitted depressed patients. Int J Psychiatry Clin Pract. 2010;14(4):268-73. https://doi.org/10.3109/13651501.2010.500737 PMid:24917438 DOI: https://doi.org/10.3109/13651501.2010.500737
Bauduin SE, van Noorden MS, van der Werff SJ, de Leeuw M, van Hemert AM, van der W NJ, et al. Elevated salivary alpha amylase level at awakening in patient with depression. Psychoneuroendocrinology. 2018;97:69-77. https://doi.org/10.1016/j.psyneuen.2018.07.001 PMid:30005283 DOI: https://doi.org/10.1016/j.psyneuen.2018.07.001
Vermetten E, Vythilingam M, Schmahl CD, Southwick SM, Charney DS, Bremner JD. Alterations in stress reactivity after long-term treatment with paroxetine in women with post-traumatic stress disorder. Ann N Y Acad Sci. 2006;1071:184-202. https://doi.org/10.1016/s0006-3223(03)00634-6 PMid:16891570 DOI: https://doi.org/10.1016/S0006-3223(03)00634-6
Ruhe HG, Khoenkhoen SJ, Ottenhof KW, Koeter MW, Mocking RJ, Schene AH. Longitudinal effects of SSRI paroxetine on salivary cortisol in major depressive disorder. Psychoneuroendocrinology. 2015;52:261-71. https://doi.org/10.1016/j.psyneuen.2014.10.024 PMid:25544738 DOI: https://doi.org/10.1016/j.psyneuen.2014.10.024
Deuschle M, Hamann B, Meichel C, Krumm B, Lederbogen F, Kniest A, et al. Antidepressive treatment with amitriptyline and paroxetine: effects on saliva cortisol concen-trations. J Clin Psychopharmacol. 2003;23(2):201-5. https://doi.org/10.1097/00004714-200304000-00014 PMid:12640223 DOI: https://doi.org/10.1097/00004714-200304000-00014
Appelhof BC, Huyser J, Verweij M, Brouwer JP, Van Dyck R, Fliers E, et al. Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression). Biol Psychiatry. 2009;59(8):696-701. https://doi.org/10.1016/j.biopsych.2005.09.008 PMid:16368077 DOI: https://doi.org/10.1016/j.biopsych.2005.09.008
Piwowarska J, Chimiak A, Matsumoto H, Dziklińska A, Radziwoń-Zaleska M, Szelenberger W, et al. Saliva cortisol concentration in patient with major depression after treatment with fluoxetine. Psychiatr Res. 2012;198(3):407-11. https://doi.org/10.1016/j.psychres.2012.01.029 PMid:22429479 DOI: https://doi.org/10.1016/j.psychres.2012.01.029
Veen G, Giltay EJ, Licht CM, Vreeburg SA, Cobbaert CM, Penninx BW, et al. Evening salivary alpha-amylase, major depressive disorder, and antidepressant use in the Netherlands study of depression and anxiety (NESDA). Psychiatr Res. 2013;208(1):41-6. https://doi.org/10.1016/j.psychres.2013.03.012 PMid:23587658 DOI: https://doi.org/10.1016/j.psychres.2013.03.012
Lisal ST, Azis U, Thioritz W, Idrus MF, Tanra AJ. The comparison of salivary alpha amylase enzym level between anxiety patients and depression patients. Int J Sci. 2017;36:334-44.
Hernández ME, Mendieta D, Martínez-Fong D, Loría F, Moreno J, Estrada I, et al. Variations in circulating cytokine levels during 52 week course of treatment with SSRI for major depressive disorder. Eur Neuropsychopharmacol. 2008;18(12):917-24. https://doi.org/10.1016/j.euroneuro.2008.08.001 PMid:18805677 DOI: https://doi.org/10.1016/j.euroneuro.2008.08.001
Blardi P, De Lalla A, Leo A, Auteri A, Iapichino S, Di Muro A, et al. Serotonin and fluoxetine levels in plasma and platelets after fluoxetine treatment in depressive patients. J Clin Psychopharmacol. 2002;22(2):131-6. https://doi.org/10.1097/00004714-200204000-00005 PMid:11910257 DOI: https://doi.org/10.1097/00004714-200204000-00005
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Copyright (c) 2021 Andi Jayalangkara Tanra, Hawaidah Madeali, Mayamariska Sanusi, Saidah Syamsuddin, Sonny Teddy Lisal (Author)
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