The Pattern of Peroxisome Proliferator-activated Receptor Gamma Coactivator 1-alpha Gene Expression in Type-2 Diabetes Mellitus Rat Model Liver: Focus on Exercise


  • Yetty Machrina Departement of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Dharma Lindarto Departement of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Yunita Sari Pane Departement of Pharmacology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Novita Sari Harahap Departement of Sport Medicine, Faculty of Sport Medicine, Universitas Negeri, Medan, Indonesia



Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, Liver, Type-2 diabetes mellitus, Rat, Exercise


BACKGROUND: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) has an important role in mitochondria biogenesis which generated cellular metabolism. Carbohydrate metabolism in the liver is crucial to maintain plasma blood glucose.

AIM: This research aimed to determine the expression of PGC-1α gene in the liver type-2 diabetes mellitus (T2DM) rat model, after treatment with a focus on exercise.

METHODS: We used 25 healthy male Wistar rats as subjects. Rats were modified to T2DM models by feeding a high-fat diet and low-dose streptozotocin injection. We divided the rats into five groups, that is, sedentary group as a control and four others as treatment groups. The exercise was assigned for treatment groups by a run on the treadmill as moderate intensity continuous (MIC), highintensity continuous (HIC), slow interval (SI), and fast interval (FI). The treatment groups were exercise throughout 8 weeks with a frequency of 3 times a week.

RESULTS: The results showed that expression of PGC-1α gene was lower in all treatment groups compared to controls (p < 0.05). Expression in HIC was higher than MIC (p < 0.05), so was the expression in FI more than SI (p < 0.05).

CONCLUSIONS: Exercise affected PGC-1α gene expression in the liver of the T2DM rat model. The expression of PGC-1α was linear with exercise intensity.


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How to Cite

Machrina Y, Lindarto D, Pane YS, Harahap NS. The Pattern of Peroxisome Proliferator-activated Receptor Gamma Coactivator 1-alpha Gene Expression in Type-2 Diabetes Mellitus Rat Model Liver: Focus on Exercise. Open Access Maced J Med Sci [Internet]. 2021 Jun. 11 [cited 2024 Jun. 15];9(T3):124-8. Available from:

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