A Single-Institute Cross-sectional Study of HCV-Positive Cancer Patients’ Quality of Life in Egypt

Authors

  • Noha Hayek Department of Public Health and Community Medicine, Theodore Bilharz Research Institute, Giza, Egypt
  • Mona El Lawindi Department of Public Health and Community Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
  • Hanan Ali Sayed Department of Public Health and Community Medicine, Theodore Bilharz Research Institute, Giza, Egypt
  • Amal Sedrak Department of Public Health and Community Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt https://orcid.org/0000-0002-6742-5295
  • Zeinab M. Abd. El Hafeez Department of Clinical Oncology, Ain Shams University, Cairo, Egypt
  • Amr Shafik Saad Department of Clinical Oncology, Ain Shams University, Cairo, Egypt https://orcid.org/0000-0003-1920-4057

DOI:

https://doi.org/10.3889/oamjms.2022.6404

Keywords:

Quality of life, Oncology, Viral hepatitis, European Organization for Treatment of Cancer Quality of Life Questionnaire -C30 v3

Abstract

BACKGROUND: Egypt is the country with the greatest number of hepatitis C virus (HCV) genotype 4 infections. The latest mass screening campaign in Egypt in 2018 reported an overall HCV seroprevalence of 4.61% (95% confidence interval 4.61 to 4.62) among the 48,345,948 subjects tested. The prevalence of HCV in the cancer population is estimated to range from 1.5 to 32%. HCV per se might directly influence health-related quality of life (HRQoL), via colonization of microglia in the brain or, indirectly, via the effect of systemic inflammatory cytokines which, in turn, can trigger brain interleukin production. Thus, there is an increased interest about the effect of the dual burden of HCV in cancer patients and its impact on the patients’’ HRQoL.

AIM: The study is conducted at the outpatient chemotherapy unit of a university hospital in Egypt, over a period of 6 months to estimate their quality of life (QoL) scores according to the European Organization for Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30 v3.

MATERIALS AND METHODS: A cross-sectional study was conducted, including all patients referred to the chemotherapy clinic during the study period and proven to be HCV positive. Recruited patients were asked to fill the EORTC QLQ-C30 v3 questionnaire, and data regarding their medical conditions were collected from their medical files.

RESULTS: One hundred and sixteen (8.8%) patients were HCV positive. QoL scores were statistically significantly lower from almost all reference values categories published in the EORTC manual.

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References

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Published

2022-05-16

How to Cite

1.
Hayek N, El Lawindi M, Sayed HA, Sedrak A, El Hafeez ZMA, Saad AS. A Single-Institute Cross-sectional Study of HCV-Positive Cancer Patients’ Quality of Life in Egypt. Open Access Maced J Med Sci [Internet]. 2022 May 16 [cited 2022 Dec. 6];10(B):1016-9. Available from: https://oamjms.eu/index.php/mjms/article/view/6404