Correlation between Grading Histopathology and Sentinel Lymph Node Metastasis in Early Breast Cancer in University of Sumatera Utara Hospital
DOI:
https://doi.org/10.3889/oamjms.2021.6423Keywords:
Breast cancer, Sentinel lymph node biopsy, Grading histopathologyAbstract
BACKGROUND: Breast cancer is a malignancy in breast tissue from the duct or lobar epithelium. American Joint Committee on Cancer has specified important prognostic factors such as primary tumor size, regional lymph node status, and distant metastasis. Axillary lymph node status has been one of the most reliable prognostic factors in early breast cancer in women. Axillary lymph node dissection is an old method to identify metastasis in axillary lymph nodes and started being replaced by sentinel lymph node biopsy (SLNB). SLNB has been introduced as a minimal invasive procedure, but in Indonesia, this procedure cannot be done due to technology limitation. Grading tumor is one of the predictor factors that can predict lymph node metastasis. This predictor factor has been associated with sentinel lymph node metastasis significantly.
AIM: According to this, we conduct this study to analyze the correlation between grading histopathology in breast cancer with sentinel lymph node metastasis to lower false-negative rate in SLNB using methylene blue dye.
MATERIALS AND METHODS: In this study, we included 51 patients that qualified using inclusion and exclusion criteria. Then, sentinel lymph node metastasis and grading histopathology data were retrieved from the patient’s medical record. This data are analyzed using SPSS with Chi-square test.
RESULTS: The most type of breast cancer in this study is invasive ductal carcinoma was found in 40 patients (78.4%). There are 22 of 51 patients (51.6%) with metastasis to sentinel lymph node, have Grade 3 in histopathologic findings.
CONCLUSIONS: The statistical evaluation showed that there is significant correlation between grading histopathology and SLNB with p = 0.001.Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Ghoncheh M, Pournamdar Z, Salehiniya H. Incidence and mortality and epidemiology of breast cancer in the world. Asian Pac J Cancer Prev. 2016;17(3):43-6. https://doi.org/10.7314/apjcp.2016.17.s3.43 PMid:27165206 DOI: https://doi.org/10.7314/APJCP.2016.17.S3.43
Siegel RL, Miller KD, Jemal A. Cancer statistics. Am Cancer Soc. 2017;67(1):7-30. https://doi.org/10.3322/caac.21387 PMid:28055103 DOI: https://doi.org/10.3322/caac.21387
National Cancer Center Dharmais Hospital. Current Cancer Situation. Ministry of Health Cancer Bulletin. Indonesia: National Cancer Center Dharmais Hospital; 2013. p. 16.
American Joint Committee for Cancer. Breast Cancer Staging System. Part XI Breast. United States: American Joint Committee for Cancer; 2018. p. 621.
Soares EW, Nagai HM, Bredt LC, da Cunha AD, Andrade RJ, Soares GV. Morbidity after conventional dissection of axillary lymph nodes in breast cancer patients. World J Surg Oncol. 2014;12:1-8. DOI: https://doi.org/10.1186/1477-7819-12-67
American Society of Clinical Oncology. Sentinel lymph node biopsy for patients with early-stage breast cancer: American society of clinical oncology clinical practice guideline update. J Clin Oncol. 2014;32(13):1365-83. https://doi.org/10.1200/jco.2016.71.0947 PMid:24663048 DOI: https://doi.org/10.1200/JCO.2016.71.0947
Nieweg OE, Uren RF, Thompson JF. The history of sentinel lymph node biopsy. Cancer J United States. 2015;21(1):3-6. https://doi.org/10.1097/ppo.0000000000000091 PMid:25611772 DOI: https://doi.org/10.1097/PPO.0000000000000091
Stevens A, Lowe J, Scott I. Core Pathology. 3rd ed. United Kingdom: Mosby Elsevier; 2009.
Brar P, Jain S, Singh I. Complications of axillary lymph node dissection in treatment of early breast cancer: A comparison of MRM and BCS. Indian J Surg Oncol. 2011;2(2):126-32. https://doi.org/10.1007/s13193-011-0078-2 Mid:22693405 DOI: https://doi.org/10.1007/s13193-011-0078-2
Bland KI, Copeland EM, Klimberg VS, Gradishar WJ, White J, Korourian S. The Breast: Comprehensive Management of Benign and Malignant Disease. 5th ed. Philadelphia, PA: Elsevier; 2018.
Schröder L, Fricker R, Stein RG, Rink T, Fitz H, Blasius S, et al. Evaluation of sentinel lymph node biopsy prior to axillary lymph node dissection: The role of isolated tumor cells/micrometastases and multifocality/multicentricity-a retrospective study of 1214 breast cancer patients. Arch Gynecol Obstet. 2018;297(6):1509- 15. https://doi.org/10.1007/s00404-018-4760-2 PMid:29594495 DOI: https://doi.org/10.1007/s00404-018-4760-2
He ZY, Wu SG, Lin HX. Breast cancer subtype is associated with axillary lymph metastatic nodes. Medicine. 2015;94(48):e2213. https://doi.org/10.1097/md.0000000000002213 PMid:26632910 DOI: https://doi.org/10.1097/MD.0000000000002213
Howland NK, Driver TD, Sedrak MP, Wen X, Dong W, Hatch S. Lymph node involvement in immunohistochemistry-based molecular classifications of breast cancer. J Surg Res. 2013;185(2):697703. https://doi.org/10.1016/j.jss.2012.10.237 PMid:24095025 DOI: https://doi.org/10.1016/j.jss.2012.10.237
Giuliano AE, Connolly JL, Edge SB, Mittendorf EA, Rugo HS, Solin LJ, et al. Breast Cancer-major changes in the American joint committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(4):290-303. https://doi.org/10.3322/caac.21393 PMid:28294295 DOI: https://doi.org/10.3322/caac.21393
Cserni G, Bianchi S, Vezzosi V, Arisio R, Bori R, Peterse JL, et al. Sentinel lymph node biopsy in staging small (Up To 15 Mm) breast carcinomas. Results from a European multi-institutional study. Pathol Oncol Res. 2007;13(1):5-14. https://doi.org/10.1007/bf02893435 PMid:17387383 DOI: https://doi.org/10.1007/BF02893435
Downloads
Published
How to Cite
License
Copyright (c) 2020 Dedy Hermansyah, Gracia Pricilia, Arjumardi Azrah, Yolanda Rahayu, Desiree A. Paramita, Edwin S. Siregar (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
http://creativecommons.org/licenses/by-nc/4.0
