Benefits of Nigella sativa Extract Protecting Ovary Due to Cisplatin Chemotherapy

Authors

  • Khairani Sukatendel Department of Obstetrics and Gynecology, Faculty of Medicine, University Sumatera Utara, Medan, Indonesia
  • M. Fidel Ganis Siregar Department of Obstetrics and Gynecology, Faculty of Medicine, University Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0002-2702-4091
  • Muharam Natadisastra Department of Obstetrics and Gynecology, Faculty of Medicine, University Indonesia, Jakarta, Indonesia
  • Iqbal Pahlevi Adiputra Nasution Doctoral Program, Faculty of Medicine, University Sumatera Utara, Medan, Indonesia
  • Syafruddin Ilyas Department of Biology, Faculty of Science, University Sumatera Utara, Medan, Indonesia
  • M. Rhiza Tala Department of Obstetrics and Gynecology, Faculty of Medicine, University Sumatera Utara, Medan, Indonesia
  • Putri Chairani Eyanoer Department of Community Medicine, Public Health, Faculty of Medicine, University Sumatera Utara, Medan, Indonesia
  • Poppy Anjelisa Z. Hasibuan Department of Pharmacology, Faculty of Pharmacy, University Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6446

Keywords:

Cisplatin, Nigella sativa, Ovary

Abstract

BACKGROUND: Cisplatin (CIS) is an important chemotherapy agent which is widely used for the treatment of many types of solid tumors, which can cause decreased ovarian function. Nigella sativa has been shown to have an anti-inflammatory and anti-oxidant activity that might protect the ovaries from damage due to CIS.

AIM: This study aims to understand the benefits of N. sativa protecting the ovaries due to CIS chemotherapy.

METHODS: Thirty-two female Rattus norvegicus aged 8 weeks weighing 160–200 g were divided into four groups: Negative control, Positive control, Treatment-1 (CIS 6 mg/KgBW and NS 500 mg/KgBW/day), and Treatment-2 (CIS 6 mg/KgBW and NS 1000 mg/kgBW/day) for 2 weeks. On the 14th day the rats were sacrificed, blood was drawn from the heart, followed by taking ovaries.

RESULTS: There was lower mortality and morbidity in CIS + NS 1000 and CIS + NS 500 mg group (p = 0.01 and 0.001). The mean estradiol levels, follicle-stimulating hormone levels, and anti-mullerian hormone levels were not statistically significant among the four groups. The highest number of primary, secondary, tertiary follicles are seen at the CIS + NS 500 mg and CIS + NS 1000 mg groups (p = 0.05). The lowest number of atretic follicles is seen at the CIS + NS 1000 mg group, and the highest number of atretic follicles was in CIS only.

CONCLUSION: There is a trend that N. sativa is beneficial in protecting the ovaries from damage caused by CIS.

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Published

2021-08-08

How to Cite

1.
Sukatendel K, Siregar MFG, Natadisastra M, Nasution IPA, Ilyas S, Tala MR, Eyanoer PC, Hasibuan PAZ. Benefits of Nigella sativa Extract Protecting Ovary Due to Cisplatin Chemotherapy. Open Access Maced J Med Sci [Internet]. 2021 Aug. 8 [cited 2024 Mar. 29];9(A):680-7. Available from: https://oamjms.eu/index.php/mjms/article/view/6446

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