Clinical Experience with PEGylated Hyaluronic Acid Fillers: A 3-year Retrospective Study
DOI:
https://doi.org/10.3889/oamjms.2021.6457Keywords:
Hyaluronic acid, PEG, PEGylated, Safety, Cross linkerAbstract
BACKGROUND: Hyaluronic acid fillers are the most used worldwide, thanks to the high biocompatibility and safety profile of HA and it is also the only substance that can be “dissolved” due to the hyaluronidase effect.
AIM: A retrospective clinical evaluation of the outcomes following PEG cross-linked HA-based filler injection was performed.
METHODS: Data were collected from December 2017 to June 2020. A total of 65 patients (12 M, 53 F), age ranging 28–62 year’s old (mean age 42.3), were treated. Exclusion criteria were applied and in accord to treatment plan, were used specific site injections and fillers. Follow-up was evaluated between 6 months and 2 years.
RESULTS: A total of 61 treatments using 124 vials of HA filler crosslinked with PEG were performed.
CONCLUSION: In conclusion, from 2014, HA fillers having PEG as cross-linker agent have been introduced in the european market. Several papers have been published in order to evaluate the features of these fillers, although, to the best of our knowledge, this is the first clinical paper regarding their use.Downloads
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Available from: https://www.cdn.surgery.org/media/statistics/aestheticplasticsurgerynationaldatabank-2020stats.pdf. [Last accessed on 2021 Apr 22].
Trinh LN, Gupta A. Hyaluronic acid fillers for midface augmentation: A systematic review. Facial Plast Surg. 2021;37(4):536-542. https://doi.org/10.1055/s-0041-1724122 PMid:33634456 DOI: https://doi.org/10.1055/s-0041-1725164
Rauso R, Sesenna E, Fragola R, Zerbinati N, Nicoletti GF, Tartaro G. Skin necrosis and vision loss or impairment after facial filler injection. J Craniofac Surg. 2020;31(8):2289-93. https://doi.org/10.1097/scs.0000000000007047 PMid:33136873 DOI: https://doi.org/10.1097/SCS.0000000000007047
Rauso R, Zerbinati N, Franco R, Chirico F, Ronchi A, Sesenna E, et al. Cross-linked hyaluronic acid filler hydrolysis with hyaluronidase: Different settings to reproduce different clinical scenarios. Dermatol Ther. 2020;33(2):e13269. https://doi.org/10.1111/dth.13269 PMid:32061001
Weiss R, Beer K, Cox SE, Palm M, Kaufman-Janette J, Bassichis B, Biesman B, et al. A Randomized, controlled, evaluator-blinded, multi-center study of hyaluronic acid filler effectiveness and safety in lip fullness augmentation. Dermatol Surg. 2021;47(4):527-32. https://doi.org/10.1097/dss.0000000000002856 PMid:33587369 DOI: https://doi.org/10.1097/DSS.0000000000002856
Rauso R, Zerbinati N, Fragola R, Nicoletti GF, Tartaro G. Transvascular hydrolysis of hyaluronic acid filler with hyaluronidase: An ex vivo study. Dermatol Surg. 2021;47(3):370-2. https://doi.org/10.1097/dss.0000000000002773 PMid:32932270 DOI: https://doi.org/10.1097/DSS.0000000000002773
Rauso R, Colella G, Franco R, Chirico F, Ronchi A, Federico F, Volpicelli A, Tartaro G. Is hyaluronidase able to reverse embolism associated with hyaluronic acid filler? An anatomical case study. J Biol Regul Homeost Agents. 2019;33(6):1927-30. PMid:31960660 DOI: https://doi.org/10.1111/dth.13269
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A, Roca-Martinez JX, et al. A review of the metabolism of 1, 4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers. Dermatol Surg. 2013;39(12):1758-66. https://doi.org/10.1111/dsu.12301 Mid:23941624 DOI: https://doi.org/10.1111/dsu.12301
Rzany B, Converset-Viethel S, Hartmann M, Larrouy JC, Ribé N, Sito G, et al. Efficacy and safety of 3 new resilient hyaluronic acid fillers, crosslinked with decreased BDDE, for the Treatment of dynamic wrinkles: Results of an 18-month, randomized controlled trial versus already available comparators. Dermatol Surg. 2019;45(10):1304-14. https://doi.org/10.1097/dss.0000000000001971 PMid:31343447 DOI: https://doi.org/10.1097/DSS.0000000000001971
Monticelli D, Martina V, Mocchi R, Rauso R, Zerbinati U, Cipolla G, et al. Chemical characterization of hydrogels crosslinked with polyethylene glycol for soft tissue augmentation. Open Access Maced J Med Sci. 2019;7(7):1077-81. https://doi.org/10.3889/oamjms.2019.279 PMid:31049084 DOI: https://doi.org/10.3889/oamjms.2019.279
Zerbinati N, D’Este E, Farina A, Rauso R, Cherubino M, Calligaro A. Morphological evidences following pegylated filler treatment in human skin. J Biol Regul Homeost Agents. 2017;31 Suppl 2:79-85.
Zerbinati N, Rauso R, Gonzalez P, Cherubino M, D’Este E, Calligaro A, et al. In vitro evaluation of collagen production on human fibroblasts treated with hyaluronic acid peg cross-linked with micromolecules of calcium hydroxyapatite in low concentration. J Biol Regul Homeost Agents. 2017;31 Suppl 2:87-90. https://doi.org/10.3889/oamjms.2018.044 PMid:28702968
Zerbinati N, Lotti T, Monticelli D, Rauso R, González-Isaza P, D’Este E, et al. In vitro Evaluation of the biosafety of hyaluronic Acid PEG cross-linked with micromolecules of calcium hydroxyapatite in low concentration. Open Access Maced J Med Sci. 2018;6(1):15-9. https://doi.org/10.3889/oamjms.2018.044 PMid:29483971 DOI: https://doi.org/10.3889/oamjms.2018.044
Salti G, Rauso R. Facial rejuvenation with fillers: The dual plane technique. J Cutan Aesthet Surg. 2015;8(3):127-33. https://doi.org/10.4103/0974-2077.167264 PMid:26644734 DOI: https://doi.org/10.4103/0974-2077.167264
Available from: https://www.surgery.org/sites/default/files/asaps-stats2016-11-12.pdf. [Last accessed on 2021 Apr 22].
Melfa F, Siragusa D, Caruso DG, Tunesi L, Zerbinati N, Chirico F, et al. An Italian experience of a new personalized injective protocol (Botutouch) for botulinum toxin application in aesthetic medicine. Dermatol Ther. 2020;33(6):e14395. https://doi.org/10.1111/dth.14395 PMid:33040423 DOI: https://doi.org/10.1111/dth.14395
Zerbinati N, Haddad RG, Bader A, Rauso R, D’Este E, Cipolla G, et al. A new hyaluronic acid polymer in the augmentation and restoration of labia majora. J Biol Regul Homeost Agents. 2017;31 Suppl 2:153-61. PMid:28702976
Rauso R, Colella G, Zerbinati N, Salti G. Safety and early satisfaction assessment of patients seeking nonsurgical rhinoplasty with filler. J Cutan Aesthet Surg. 2017;10(4):207-14. https://doi.org/10.4103/jcas.jcas_89_17 PMid:29491656 DOI: https://doi.org/10.4103/JCAS.JCAS_89_17
Rauso R, Lo Giudice G, Zerbinati N, Tartaro G. Hyaluronic acid injections as nonsurgical alternative in case of delayed diagnosis of malar arch fracture: Case report and literature review. Case Rep Surg. 2019;2019:1360741. https://doi.org/10.1155/2019/1360741 PMid:31976115 DOI: https://doi.org/10.1155/2019/1360741
Rauso R, Tartaro G, Chirico F, Zerbinati N, Albani G, Rugge L. Rhinofilling with hyaluronic acid thought as a cartilage graft. J Craniomaxillofac Surg. 2020;48(3):223-8. https://doi.org/10.1016/j.jcms.2020.01.008 PMid:32107120 DOI: https://doi.org/10.1016/j.jcms.2020.01.008
Rauso R, Federico F, Zerbinati N, de Cicco D, Nicoletti GF, Tartaro G. Hyaluronic acid injections to correct lips deformity following surgical removal of permanent implant. J Craniofac Surg. 2020;31(6):e604-6. https://doi.org/10.1097/scs.0000000000006689 PMid:32657979 DOI: https://doi.org/10.1097/SCS.0000000000006689
Borzacchiello A, Russo L, Malle BM, Schwach-Abdellaoui K, Ambrosio L. Hyaluronic acid based hydrogels for regenerative medicine applications. Biomed Res Int. 2015;2015:871218. https://doi.org/10.1155/2015/871218 Mid:26090451 DOI: https://doi.org/10.1155/2015/871218
Zerbinati N, Sommatis S, Maccario C, Capillo MC, Grimaldi G, Alonci G, et al. Toward physicochemical and rheological characterization of different injectable hyaluronic acid dermal fillers cross-linked with polyethylene glycol diglycidyl ether. Polymers (Basel). 2021;13(6):948. https://doi.org/10.3390/polym13060948 PMid:33808730 DOI: https://doi.org/10.3390/polym13060948
Zerbinati N, Esposito C, Cipolla G, Calligaro A, Monticelli D, Martina V, et al. Chemical and mechanical characterization of hyaluronic acid hydrogel cross-linked with polyethylen glycol and its use in dermatology. Dermatol Ther. 2020;33(4):e13747. https://doi.org/10.1111/dth.13747 PMid:32475040 DOI: https://doi.org/10.1111/dth.13747
Zerbinati N, Rauso R, Protasoni M, D’Este E, Esposito C, Lotti T, et al. Pegylated hyaluronic acid filler enriched with calcium hydroxyapatite treatment of human skin: Collagen renewal demonstrated through morphometric computerized analysis. J Biol Regul Homeost Agents. 2019;33(6):1967-71. PMid:31920061
Zerbinati N, Mocchi R, Galadari H, Maccario C, Maggi M, Rauso R, et al. In vitro evaluation of the biological availability of hyaluronic acid polyethylene glycols-cross-linked hydrogels to bovine testes hyaluronidase. Biomed Res Int. 2019;2019:3196723. https://doi.org/10.1155/2019/3196723 PMid:31309104 DOI: https://doi.org/10.1155/2019/3196723
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Copyright (c) 2020 Raffaele Rauso, Giovanni Francesco Nicoletti, Pierfrancesco Bove, Giuseppe M. Rauso, Romolo Fragola, Giorgio Lo Giudice, Nicola Zerbinati (Author)
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