Association of Polymorphism +874 T/A Interferon Gamma Gene with Susceptibility to Pulmonary Tuberculosis in Medan, Indonesia

Sri Melinda Kaban; Bintang Yinke Magdalena Sinaga; Tetty Aman Nasution

doi:10.3889/oamjms.2021.6480

Authors

Sri Melinda Kaban Master Program in Tropical Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0003-2854-6630
Bintang Yinke Magdalena Sinaga Departement of Pulmonology and Respirology Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Tetty Aman Nasution Department of Microbiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6480

Keywords:

Polymorphism, Interferon gamma, pulmonary tuberculosis

Abstract

BACKGROUND: Pulmonary tuberculosis (TB) is still a disease that concerns in the world due to its high incidence, especially in developing countries, including Indonesia. Polymorphism +874 T/A interferon-gamma (IFN-γ) is one of the host genetic factors that have been widely studied and has been shown to be associated with susceptibility to pulmonary TB.

AIM: This study aims to determine the association polymorphism +874 T/A IFN-γ gene with susceptibility to pulmonary TB in Medan population.

METHODS: A total of 82 pulmonary TB patients and 85 healthy controls were examined in this case–control study. SPSS 25 is used to process and analyze all data where the Pearson Chi-square is used to analyze the association between genotype and susceptibility to pulmonary TB.

RESULTS: The polymorphism +874 T/A IFN-γ gene was not significantly associated with susceptibility to pulmonary TB in patients compared to controls (p = 0.395) and there was no association between allele frequency and susceptibility to pulmonary TB (p = 0.158).

CONCLUSION: Our study suggests no association of polymorphism +874 T/A IFN-γ gene with pulmonary TB in Medan, Sumatera Utara, Indonesia.

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