Association of Polymorphism +874 T/A Interferon Gamma Gene with Susceptibility to Pulmonary Tuberculosis in Medan, Indonesia


  • Sri Melinda Kaban Master Program in Tropical Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Bintang Yinke Magdalena Sinaga Departement of Pulmonology and Respirology Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Tetty Aman Nasution Department of Microbiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia



Polymorphism, Interferon gamma, pulmonary tuberculosis


BACKGROUND: Pulmonary tuberculosis (TB) is still a disease that concerns in the world due to its high incidence, especially in developing countries, including Indonesia. Polymorphism +874 T/A interferon-gamma (IFN-γ) is one of the host genetic factors that have been widely studied and has been shown to be associated with susceptibility to pulmonary TB.

AIM: This study aims to determine the association polymorphism +874 T/A IFN-γ gene with susceptibility to pulmonary TB in Medan population.

METHODS: A total of 82 pulmonary TB patients and 85 healthy controls were examined in this case–control study. SPSS 25 is used to process and analyze all data where the Pearson Chi-square is used to analyze the association between genotype and susceptibility to pulmonary TB.

RESULTS: The polymorphism +874 T/A IFN-γ gene was not significantly associated with susceptibility to pulmonary TB in patients compared to controls (p = 0.395) and there was no association between allele frequency and susceptibility to pulmonary TB (p = 0.158).

CONCLUSION: Our study suggests no association of polymorphism +874 T/A IFN-γ gene with pulmonary TB in Medan, Sumatera Utara, Indonesia.


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How to Cite

Kaban SM, Sinaga BYM, Nasution TA. Association of Polymorphism +874 T/A Interferon Gamma Gene with Susceptibility to Pulmonary Tuberculosis in Medan, Indonesia. Open Access Maced J Med Sci [Internet]. 2021 Aug. 9 [cited 2024 Apr. 12];9(A):515-9. Available from:

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