Incision Wound Healing Test of Ethanolic Extract Gel from Salaon (Parsonsia alboflavescens [Dennst.] Mabb.) Leaves in Male Rats

Authors

  • Nilsya Zebua Department of Pharmacy, Faculty of Pharmacy, Tjut Nyak Dhien University, Sumatera Utara, Indonesia https://orcid.org/0000-0002-4877-9960
  • Muharni Saputri Department of Pharmacy, Faculty of Pharmacy, Tjut Nyak Dhien University, Sumatera Utara, Indonesia
  • Winda Giovana Sijabat Department of Pharmacy, Faculty of Pharmacy, Tjut Nyak Dhien University, Sumatera Utara, Indonesia
  • Inda Aristika Sri Retno Wulandari Department of Pharmacy, Faculty of Pharmacy, Tjut Nyak Dhien University, Sumatera Utara, Indonesia
  • Ira Nofriani Department of Pharmacy, Faculty of Pharmacy, Tjut Nyak Dhien University, Sumatera Utara, Indonesia
  • Winda Agustiani Zai Department of Pharmacy, Faculty of Pharmacy, Tjut Nyak Dhien University, Sumatera Utara, Indonesia
  • Ramadani Arda Arista Department of Pharmacy, Faculty of Pharmacy, Tjut Nyak Dhien University, Sumatera Utara, Indonesia
  • Muhammad Suhaimi Department of Pharmacy, Faculty of Pharmacy, Tjut Nyak Dhien University, Sumatera Utara, Indonesia
  • Aula Firsa Department of Pharmacy, Faculty of Pharmacy, Tjut Nyak Dhien University, Sumatera Utara, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6662

Keywords:

Arenga gum, Gel, Incision wound, Rats, Salaon leaves

Abstract

BACKGROUND: An incision wound is a wound caused by a sharp object. One of the plants that can be used as a traditional medicine for an incision wound is salaon leaves. The prepared form chosen is the gel because it is easy to use and its distribution is faster on the skin.

AIM: The aim of the study was to explore whether salaon leaf extract gel meets the quality evaluation requirements and to know the effectiveness of ethanol extract gel of salaon (Parsonsia alboflavescens [Dennst] Mabb.) leaves to cure a scar on male rats.

METHODS: Experimental method with salaon leaves as sample. Simplicia of salaon leaves extracted by maceration method, and then arenga gum gel-based formulation, afterward evaluation, and testing of its effectiveness on the healing of incision wound of male rats. Normal data were analyzed by the One Way Analysis of variance (ANOVA) and Post Hoc Tuckey Method. Kruskal-Wallis test used for abnormal data.

RESULTS: The whole formula shows homogenous results, normal pH, stability, dissemination and good viscosity, less irritating, and with good adhesion. The results of a statistical analysis of the wound on the 8th day with ANOVA test indicate a significant difference between the five groups p = 0.000 (p < 0.05) and Post-Hoc Tukey Honest Significant Difference test results obtained a concentration of 5% not significantly different from the positive control Placenta extract gel. The optimum dose that can heal incision wound in male rats is 5%.

CONCLUSION: The whole formulation qualifies for the quality of the gel formulation. Ethanol extract gel of salaon leaves can heal wound on male rats and the optimal dose is 5%.

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Published

2021-09-04

How to Cite

1.
Zebua N, Saputri M, Sijabat WG, Wulandari IASR, Nofriani I, Zai WA, Arista RA, Suhaimi M, Firsa A. Incision Wound Healing Test of Ethanolic Extract Gel from Salaon (Parsonsia alboflavescens [Dennst.] Mabb.) Leaves in Male Rats. Open Access Maced J Med Sci [Internet]. 2021 Sep. 4 [cited 2024 Mar. 28];9(A):776-81. Available from: https://oamjms.eu/index.php/mjms/article/view/6662