The Role of Bamboo Shoot Gigantochloa Apus Extract in Decreasing the IL-17/IL-10 Ratio Level in the Atherosclerosis Process

Edy Soesanto; Satriya Pranata; Sri Rejeki; Lalu Muhammad Irham

doi:10.3889/oamjms.2021.6675

Authors

Edy Soesanto Department of Nursing, Faculty of Nursing and Health Sciences, Universitas Muhammadiyah Semarang, Central Java, Semarang, Indonesia
Satriya Pranata School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan https://orcid.org/0000-0002-2026-8931
Sri Rejeki Department of Nursing, Faculty of Nursing and Health Sciences, Universitas Muhammadiyah Semarang, Central Java, Semarang, Indonesia
Lalu Muhammad Irham Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia https://orcid.org/0000-0002-0091-4887

DOI:

https://doi.org/10.3889/oamjms.2021.6675

Keywords:

Bamboo shoot, Gigantochloa apus extract, Interleukin-17, Interleukin-10, Atherosclerosis

Abstract

BACKGROUND: Atherosclerosis begins with injury to the endothelial, progressive, and increases by 3% per year since the age of a person passes 20 years. The ratio of the number of pro and anti-inflammatory cytokines can describe the development of the process of atherosclerosis so that the higher the ratio will increase the chance of atherosclerosis.

AIM: The purpose of this study was to examine the effect of Bamboo shoot Gigantochloa apus (BSGA) extract on decreasing interleukin-17 (IL-17)/IL-10 level ratios in New Zealand White rabbits given an atherogenic diet.

METHODS: This study uses BSGA extract freeze-dried aged 1–2 weeks and New Zealand White rabbits. Atherogenic feed uses 0.5% egg yolk and 5% pork oil which is added to the standard feed. Randomized pre- and post-test with control group design by dividing into four groups were used in this study.

RESULTS: The mean ratio of IL-17 levels with IL-10 between before and after (p < 0.005) in all groups showed a significant difference. There was a trend of increasing the ratio between IL-17 levels and IL-10 in all groups and the highest increase occurred in the control group which was 420%.

CONCLUSION: The higher the dose of BSGA extract administration could reduce the ratio between IL-17 levels and IL-10 and there is a correlation with a negative linear pattern between IL-10 and IL-17 with p = 0.034 which means that higher levels of IL-10 will reduce IL-17 levels.

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