The Role of Bamboo Shoot Gigantochloa Apus Extract in Decreasing the IL-17/IL-10 Ratio Level in the Atherosclerosis Process

Authors

  • Edy Soesanto Department of Nursing, Faculty of Nursing and Health Sciences, Universitas Muhammadiyah Semarang, Central Java, Semarang, Indonesia
  • Satriya Pranata School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan https://orcid.org/0000-0002-2026-8931
  • Sri Rejeki Department of Nursing, Faculty of Nursing and Health Sciences, Universitas Muhammadiyah Semarang, Central Java, Semarang, Indonesia
  • Lalu Muhammad Irham Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia https://orcid.org/0000-0002-0091-4887

DOI:

https://doi.org/10.3889/oamjms.2021.6675

Keywords:

Bamboo shoot, Gigantochloa apus extract, Interleukin-17, Interleukin-10, Atherosclerosis

Abstract

BACKGROUND: Atherosclerosis begins with injury to the endothelial, progressive, and increases by 3% per year since the age of a person passes 20 years. The ratio of the number of pro and anti-inflammatory cytokines can describe the development of the process of atherosclerosis so that the higher the ratio will increase the chance of atherosclerosis.

AIM: The purpose of this study was to examine the effect of Bamboo shoot Gigantochloa apus (BSGA) extract on decreasing interleukin-17 (IL-17)/IL-10 level ratios in New Zealand White rabbits given an atherogenic diet.

METHODS: This study uses BSGA extract freeze-dried aged 1–2 weeks and New Zealand White rabbits. Atherogenic feed uses 0.5% egg yolk and 5% pork oil which is added to the standard feed. Randomized pre- and post-test with control group design by dividing into four groups were used in this study.

RESULTS: The mean ratio of IL-17 levels with IL-10 between before and after (p < 0.005) in all groups showed a significant difference. There was a trend of increasing the ratio between IL-17 levels and IL-10 in all groups and the highest increase occurred in the control group which was 420%.

CONCLUSION: The higher the dose of BSGA extract administration could reduce the ratio between IL-17 levels and IL-10 and there is a correlation with a negative linear pattern between IL-10 and IL-17 with p = 0.034 which means that higher levels of IL-10 will reduce IL-17 levels.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, et al. Heart disease and stroke statistics-2020 update: A report from the American heart association. Circulation. 2020;141(9):139-596. PMid:31992061

Mulyadi PB. Clinical pathology and Majalah patologi klinik Indonesia dan Laboratorium Medik. J Indones. 2006;21(3):261-5.

Galkina E, Ley K. Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol. 2009;27:165-97. https://doi.org/10.1146/annurev.immunol.021908.132620 PMid:19302038 DOI: https://doi.org/10.1146/annurev.immunol.021908.132620

Tousoulis D, Oikonomou E, Economou EK, Crea F, Kaski JC. Inflammatory cytokines in atherosclerosis: Current therapeutic approaches. Eur Heart J. 2016;37(22):1723-32. https://doi.org/10.1093/eurheartj/ehv759 PMid:26843277 DOI: https://doi.org/10.1093/eurheartj/ehv759

Gradinaru D, Borsa C, Ionescu C, Prada GI. Oxidized LDL and NO synthesis--Biomarkers of endothelial dysfunction and ageing. Mech Ageing Dev. 2015;151:101-13. https://doi.org/10.1016/j.mad.2015.03.003 PMid:25804383 DOI: https://doi.org/10.1016/j.mad.2015.03.003

Quispe-Tintaya W. HHS public access. Physiol Behav. 2017;176(3):139-48. PMid:28363838

Karakas M, Koenig W. The role of inflammation in atherosclerosis-an update. Klinikarzt. 2010;39(3):140-6. DOI: https://doi.org/10.1055/s-0030-1253323

Soesanto E. Analysis proximate, HCN, antioxidant compounds and antioxidant activities of potential extract as antiatherosclerosis. Med Keperawatan Indones. 2018;1(3):32. https://doi.org/10.26714/mki.1.3.2018.32-45 DOI: https://doi.org/10.26714/mki.1.3.2018.32-45

Soesanto E. Uji aktivitas antioksidan ekstrak rebung bambu apus (gigantochloa apus Kurz) terhadap 1,1-diphenyl-2- picrylhidrazyl (DPPH). Cendekia J Pharm. 2018;2(2):88-94. https://doi.org/10.31596/cjp.v2i2.22 DOI: https://doi.org/10.31596/cjp.v2i2.22

Soesanto E. Antioxidant activity of extracts from Bambusa vulgaris and Gigantochloa apus Kurz Bamboo shoots. Pak J Nutr. 2016;15:580-4. https://doi.org/10.3923/pjn.2016.580.584 DOI: https://doi.org/10.3923/pjn.2016.580.584

Iwakura Y, Ishigame H, Saijo S, Nakae S. Functional specialization of interleukin-17 family members. Immunity. 2011;34(2):149-62. https://doi.org/10.1016/j.immuni.2011.02.012 PMid:21349428 DOI: https://doi.org/10.1016/j.immuni.2011.02.012

Ait-Oufella H, Taleb S, Mallat Z, Tedgui A. Recent advances on the role of cytokines in atherosclerosis. Arterioscler Thromb Vasc Biol. 2011;31(5):969-79. https://doi.org/10.1161/atvbaha.110.207415 PMid:21508343 DOI: https://doi.org/10.1161/ATVBAHA.110.207415

Tedgui A, Mallat Z. Cytokines in atherosclerosis: Pathogenic and regulatory pathways. Physiol Rev. 2006;86(2):515-81. https://doi.org/10.1152/physrev.00024.2005 PMid:16601268 DOI: https://doi.org/10.1152/physrev.00024.2005

Soehnlein O. Multiple roles for neutrophils in atherosclerosis. Circ Res. 2012;110(6):875-88. PMid:22427325 DOI: https://doi.org/10.1161/CIRCRESAHA.111.257535

Downloads

Published

2021-10-16

How to Cite

1.
Soesanto E, Pranata S, Rejeki S, Irham LM. The Role of Bamboo Shoot Gigantochloa Apus Extract in Decreasing the IL-17/IL-10 Ratio Level in the Atherosclerosis Process. Open Access Maced J Med Sci [Internet]. 2021 Oct. 16 [cited 2024 Jun. 17];9(A):817-21. Available from: https://oamjms.eu/index.php/mjms/article/view/6675

Most read articles by the same author(s)