The Role of Sex, Ethnicity, Age, and Nutritional Status in the Seropositivity of the Measles Vaccine

H. R. Teni Nurlatifah; Wisnu Barlianto; I Wayan Arsana Wiyasa; H. M. S. Chandra Kusuma; Tita Luthfia Sari; Novilia Sjafri Bachtiar

doi:10.3889/oamjms.2021.6685

Authors

H. R. Teni Nurlatifah Doctoral Program of Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia; Department of Applied Midwifery, Master’s Study Program, STIKes Dharma Husada, Bandung, West Java, Indonesia
Wisnu Barlianto Department of Pediatric, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia https://orcid.org/0000-0001-6566-5335
I Wayan Arsana Wiyasa Department of Obstetrics and Gynecology, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia
H. M. S. Chandra Kusuma Department of Pediatric, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia
Tita Luthfia Sari Department of Pediatric, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia
Novilia Sjafri Bachtiar Bio Farma, Bandung, West Java, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6685

Keywords:

Antibody, Determinant factors, Immunization, Measles, Seroconversion

Abstract

AIM: This study investigates the relationship between sex, ethnicity, age, nutritional status with the seropositivity of the Edmonston-Zagreb vaccine in children.

METHODS: A cross sectional, observational study was conducted. A total of 45 children were differentiated based on sex, ethnicity, age, and nutritional status when they received the Edmonston-Zagreb measle vaccine for the first time. Flow cytometry was used to look at differences in antibody status as well as populations of CD-4 and CD-8 cells that release IFN- γ.

RESULTS: We found no significant differences in antibody levels or CD-4 and CD-8 cell populations that secrete IFN- γ between boys and girls (p > 0.05). Besides, similar results were also confirmed in comparisons between Javanese and Sundanese ethnic groups, 9 months versus more than 9 months of age, or normal versus low body mass index (p > 0.05).

CONCLUSIONS: We conclude that sex, race, age, and nutritional status had no effect on immune response to vaccination. As a result, there was no barrier to seroconversion and optimal immunological performance in the children in this trial who received the Edmonston-Zagreb measles vaccination.

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