Analysis of Delivery in Singleton Pregnancies Achieved by In Vitro Fertilization
DOI:
https://doi.org/10.3889/oamjms.2021.6705Keywords:
In vitro fertilization, Operative vaginal birth, Induction of labor, Postpartum haemorrhageAbstract
BACKGROUND: Birth after IVF is increasingly observed in modern obstetrics, so knowledge of its features is of paramount importance for clinical practice.
AIM: The purpose of our study was to compare IVF and spontaneous singleton pregnancies in terms of cesarean section rate, operative vaginal birth rate, induction of labor, manual removal of the placenta in vaginal births, severe PPH and need for blood transfusion after delivery.
MATERIAL AND METHODS: We conducted a retrospective study at "Maichin Dom" University Hospital in Sofia, Bulgaria for the period from January 2013 to December 2017 and analyzed 402 singleton IVF pregnancies and compared them with 523 spontaneous singleton pregnancies
RESULTS: We found a significantly higher rate of cesarean sections in IVF compared to spontaneous pregnancies [OR 1.73; 95% CI 1.4-2.14; p<0.001]. Vaginal delivery after IVF is associated with a higher incidence of operative vaginal delivery than spontaneous pregnancies [OR 2.27; 95% CI 1.14 - 4.52; p=0.018]. No statistical differences in rates of labor induction and manual removal of the placenta between two groups were estimated (p>0.05). Severe PPH and blood transfusions were three times higher in patients after IVF undergoing a cesarean section than in those with spontaneous singleton pregnancies [OR 3.0; 95% CI 1.11 - 8.11; p=0.018].
CONCLUSION: IVF singleton pregnancies are associated with a higher risk of cesarean section as well as some obstetric complications. Obstetricians should treat these pregnancies with caution in order to reduce cesarean section rate and improve the outcome.
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Younger M, Hollins-Martin C, Choucri L. Individualised care for women with assisted conception pregnancies and midwifery practice implications: An analysis of the existing research and current practice. Midwifery. 2015;31(2):265-70. https://doi.org/10.1016/j.midw.2014.06.008 DOI: https://doi.org/10.1016/j.midw.2014.06.008
Kostov I, Ivanov ST. Prevention and prophylaxis in obstetrics and gynecology. Akusherst Ginekol. 2018;57(2):57-8.
Helmerhorst FM, Perquin DA, Donker D, Keirse M. Perinatal outcome of singletons and twins after assisted conception: A systematic review of controlled studies. BMJ. 2004;328(7434):261. https://doi.org/10.1136/ bmj.37957.560278.ee PMid:14742347 DOI: https://doi.org/10.1136/bmj.37957.560278.EE
Jackson RA, Gibson KA, Wu YW, Croughan M. Perinatal outcomes in singletons following in vitro fertilization: A meta-analysis. Obstet Gynecol. 2004;103(3):551-63. https://doi.org/10.1097/01.aog.0000114989.84822.51 PMid:14990421 DOI: https://doi.org/10.1097/01.AOG.0000114989.84822.51
Yunakova M, Gogova G, Antonova I, Veleva G, Kostov I, Shterev A. Age as a predictive marker of assisted reproductive technologies outcome. Akusherstvo Ginekol. 2017;56(6):17-21.
Kostov I, Yunakova M, Georgiev B, Petrova Z. Analysis of the quality of medical services in obstetrics and gynecology practice in Bulgaria-a study in organizational, clinical and deontological aspects. Akusherstvo Ginekol. 2017;56(6):9-16.
Shevell T, Malone F, Vidaver J, Porter T, Luthy D, Comstock C, et al. Assisted reproductive technology and pregnancy outcome. Obstetr Gynecol. 2005;106(5):1039-45. https://doi.org/10.1097/01.aog.0000183593.24583.7c PMid:16260523 DOI: https://doi.org/10.1097/01.AOG.0000183593.24583.7c
Silberstein T, Sheiner E, Levy A, Herlev A, Saphier O. Perinatal outcome of pregnancies following in vitro fertilization and ovulation induction. J Matern Fetal Neonatal Med. 2014;27(13):1316-9. https://doi.org/10.3109/14767058.2013.85 6415 PMid:24175873 DOI: https://doi.org/10.3109/14767058.2013.856415
Sullivan E, Chapman M, Wang YA, Adamson G. Population-based study of cesarean section after in vitro fertilization in Australia. BIRTH. 2010;37(3):184-91. https://doi.org/10.1111/j.1523-536x.2010.00405.x PMid:20887534 DOI: https://doi.org/10.1111/j.1523-536X.2010.00405.x
Vilchez G, Dai J, Hoyos LR, Babbar S, Bahado-Singh R, Maulik D, et al. Optimal delivery mode in singleton pregnancies conceived after infertility treatment: Is the “precious baby” effect justified? Am J Obstetr Gynecol. 2016;214(1):445-6. https://doi.org/10.1016/j.ajog.2015.10.906 DOI: https://doi.org/10.1016/j.ajog.2015.10.906
Belanoff C, Declercq E, Diop H, Gopal D, Kotelchuck M, Luke B. Severe maternal morbidity and the use of assisted reproductive technology in Massachusetts. Obstet Gynecol. 2016;127(3):527-34. https://doi.org/10.1097/aog.0000000000001292 PMid:26855105 DOI: https://doi.org/10.1097/AOG.0000000000001292
Martin A, Mansour M, Kissin D, Jamieson DJ, Callaghan WM, Boulet SL. Trends in severe maternal morbidity after assisted reproductive technology in the United States, 2008-2012. Obstet Gynecol. 2016;127(1):59-66. https://doi.org/10.1097/aog.0000000000001197 PMid:26646124 DOI: https://doi.org/10.1097/AOG.0000000000001197
Bulletins-Obstetrics CP. Practice bulletin No. 183: “Postpartum hemorrhage”. Obstet Gynecol. 2017;130:e168-86. https://doi.org/10.1097/aog.0000000000002351 PMid:28937571 DOI: https://doi.org/10.1097/AOG.0000000000002351
Dimitrov A. Contemporary Problems of Abdominal Delivery, D.Sc. Thesis. Bulgaria: Medical University, Sofia; 2003. p. 154-5. https://doi.org/10.1093/hropen/hoy012
Vannuccini S, Ferrata C, Parelli F, Pinzauti S, Severi F, Reis F, et al. Peripartum and postpartum outcomes in uncomplicated term pregnancy following ART: A retrospective cohort study from two Italian obstetric units. Hum Reprod. 2018;3:1-8. PMid:30895253 DOI: https://doi.org/10.1093/hropen/hoy012
Koudstaal J, Braat DD, Bruinse HW, Naaktgeboren N, Vermeiden JP, Visser GH. Obstetric outcome of singleton pregnancies after IVF: A matched control study in four Dutch university hospitals. Hum Reprod. 2000;15(8):1819-25. https://doi.org/10.1093/humrep/15.8.1819 PMid:10920110 DOI: https://doi.org/10.1093/humrep/15.8.1819
Shufaro Y, Oron S, Sapir O, Pinkas H, Ben-Haroush A, Shochat T, et al. IVF is an Independent Risk Factor for Third Stage of Labor Complications Following Successful Vaginal Deliveries. Geneva: ESHRE; 2017. https://doi.org/10.26226/morressier.5912d9efd462b8029238684b DOI: https://doi.org/10.26226/morressier.5912d9efd462b8029238684b
Korosec S, Frangez HB, Verdenik I, Kladnik U, Kotar V, Virant-Klun I, et al. Singleton pregnancy outcomes after in vitro fertilization with fresh or frozen-thawed embryo transfer and incidence of placenta praevia. BioMed Res Int. 2014;2014:431797 https://doi.org/10.1155/2014/431797 PMid:24822209 DOI: https://doi.org/10.1155/2014/431797
Sazonova A, Kallen K, Thurin-Kjellberg A, Wennerholm UB, Bergh C. Obstetric outcome in singletons after in vitro fertilization with cryopreserved/thawed embryos. Hum Reprod. 2012;27(5):1343-50. https://doi.org/10.1093/humrep/des036 PMid:22362926 DOI: https://doi.org/10.1093/humrep/des036
Kostov I, Ivanov St. Recommendation for intrapartum management of intraamniotic infections. Akusherstvo Ginekol. 2018;57(2):50-6.
Yunakova M, Surcheva H, Andreeva P, Veleva G, Kostov I, Shterev A. Comparison of prognostic value of markers of ovarian reserve. Akusherstvo Ginekol. 2017;56(6):3-9.
Yanaihara A, Ohgi S, Motomura K, Hirano A, Takanaka S, Yanaihara T. In vitro fertilization pregnancy is one of the risk factors for atonic bleeding in problem-free pregnancy. J Pregnancy Child Health. 2017;4(1):1000308. DOI: https://doi.org/10.4172/2376-127X.1000308
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Copyright (c) 2020 Sergei Slavov, Gergana Ingilizova, Galina Yaneva (Author)
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