The Role of Interleukin in Ectopic Pregnancy: A Systematic Review

Cahyono Hadi; Jethro Budiman; Awal Prasetyo; Cipta Pramana

doi:10.3889/oamjms.2021.6718

Authors

Cahyono Hadi Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada (FK-KMK UGM), Yogyakarta, Indonesia
Jethro Budiman Department of Emergency Unit, Panti Wilasa Citarum Hospital, Semarang, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Diponegoro University, dr. Kariadi Hospital, Semarang, Indonesia https://orcid.org/0000-0001-8574-9069
Awal Prasetyo Department of Anatomic Pathology, Faculty of Medicine, Diponegoro University, dr. Kariadi Hospital, Semarang, Indonesia; Department of Biomedical Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
Cipta Pramana Department of Obstetrics and Gynecology, K.R.M.T. Wongsonegoro Hospital, Semarang, Indonesia; Department of Obstetrics and Gynecology, Medical Faculty, Tarumanagara University, Jakarta, Indonesia https://orcid.org/0000-0001-8991-0147

DOI:

https://doi.org/10.3889/oamjms.2021.6718

Keywords:

Ectopic pregnancy, Interleukin, Tubal ectopic pregnancy

Abstract

BACKGROUND: Ectopic pregnancy (EP) is the implantation of an embryo outside the eutopic cavity with the most location of EP is in the fallopian tube (FT), known as tubal EP (TEP). The FT of TEP expresses higher levels of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-6, and IL-8.

AIM: The study aimed to look systematically into the current literature and carefully analyze the results to explore the role of IL in EP.

METHODS: Three independent reviewers conducted the literature search through some electronic databases searching for articles fulfilling inclusion and exclusion criteria. The lead author independently assessed the risk of bias of each of the 313 articles identified in database searching, 12 articles met the criteria for this review.

CONCLUSION: IL-6 and IL-8 have diagnostic significance in predicting EP with the cutoff levels of IL-6 and IL-8 which were 26.48 and 40 pg/mL. Further, research is needed for the role of other interleukins in EP.

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