Assessment of Contralateral Biopsy Technique for Improving Tissue Changes in Patients with Tongue Malignancy


  • Nawres Alhatab Department of Surgery, College of Dentistry, University of Al-Ameed, Karbala, Iraq
  • Muntathar Muhsen Abusanna Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Al-Ameed, Karbala, Iraq
  • Hydar Salih Department of Surgery, College of Dentistry, Al-Mashreq University, Baghdad, Iraq



Contralateral biopsy technique, Tissue changes, Tongue malignancy


Background: Oral cancer is one of the most common type of head and neck cancer, with a 5 year survival rate of < 50%. One of the major problems of oral cancer include the late stage of disease at the time of diagnosis. Mirror image biopsy is a new technique that can be used for detection of early changes in the oral mucosa. Aim of the study: To histologically assess the reflect copy biopsy occupied from clinically usual observing mucosa at consistent contralateral  anatomical place to the main lesion in patients identified with tongue squamous cell carcinoma to notice any indication of arena alteration in oral mucosa. Materials and methods: Seven patients diagnosed with squamous cell carcinoma of the tongue underwent reflect copy biopsy from clinically usual observing mucosa at consistent contralateral anatomical place to the main lesion. The reflect copy biopsy example were exposed to histopathological check. Results: of the seven patients included, four were male and three were female, with an age range from 45 years to 64 years (median 54.5 years). One of the biopsies revealed severe dysplasia and six-revealed hyperplasia of the epithelium. Conclusion: Mirror image biopsy is a useful tool to detect the early field changes in oral mucosa in order to prevent further progression to oral cancer.


Download data is not yet available.


Metrics Loading ...

Plum Analytics Artifact Widget Block


Pires FR, Ramos AB, Oliveira JB, Tavares AS, Luz PS, Santos TC. Oral squamous cell carcinoma: Clinicopathological features from 346 cases from a single oral pathology service during an 8-year period. J Appl Oral Sci. 2013;21(5):460-7. PMid:24212993 DOI:

González-Moles MA, Plaza-Campillo J, Ruiz-Ávila I, Herrera P, Bravo M, Gil-Montoya JA. Asymmetrical proliferative pattern loss during malignant transformation of the oral mucosa. J Oral Pathol Med. 2014;43(7):507-13. PMid:25184162 DOI:

AIRTUM Working Group. Italian cancer figures, report 2013: Multiple tumours. Epidemiol Prev. 2013;37(4-5 Suppl 1):1-152. PMid:24259384

Rahman QB, Bajgai DP. Evaluation of Incidence of Premalignant and Malignant Lesions by Mirror Image Biopsy in Oral Squamous Cell Carcinoma. Cosmetol Oro Fac Surg. 2017;3:118.

Floriano PN, Abram T, Taylor L, Le C, Talavera H, Nguyen M, et al. Programmable bio-nanochip-based cytologic testing of oral potentially malignant disorders in Fanconi anemia. Oral Dis. 2015;21(5):593-601. PMid:25662766 DOI:

Wei ZH, Gong W, Zhou M, Chen QM. The concept of field cancerization and its clinical application. Zhonghua Kou Qiang Yi Xue Za Zhi. 2016;51(9):562-5. PMid:27596348

Sabharwal R, Mahendra A, Moon NJ, Gupta P, Jain A, Gupta S. Genetically altered fields in head and neck cancer and second field tumor. South Asian J Cancer. 2014;3(3):151-3. PMid:25136520 DOI:

Mohan M, Jagannathan N. Oral field cancerization: An update on current concepts. Oncol Rev. 2014;8(1):244. PMid:25992232 DOI:

Achalli S, Babu SG, Shetty SR, Madi M. Oral field cancerization: A case report. Int J Dent Med Res. 2014:1(3):46-8.

Koo K, Harris R, Wiesenfeld D, Iseli TA. A role for panendoscopy? Second primary tumour in early stage squamous cell carcinoma of the oral tongue. J Laryngol Otol. 2015;129(Suppl 1):S27-31. PMid:25656280 DOI:

Sarode SC, Sarode G, Patil S. Site-specific oral cancers are different biological entities. J Contemp Dent Pract. 2017;18(6):421-2. PMid:28621267 DOI:

Richter I, Alajbeg I, Boras VV, Rogulj AA, Brailo V. Mapping electrical impedance spectra of the healthy oral mucosa: A pilot study. Acta Stomatol Croat. 2015;49(4):331-9. PMid:27688418 DOI:

Hebbale MA, Krishnappa R, Bagewadi A, Keloskar V, Kale A, Halli R. Evaluation of mirror image biopsy for incidence of multiple premalignant and malignant lesions in oral cancer a clinical study. J Indian Acad Oral Med Radiol. 2012;24(3):194-9. DOI:

Nanayakkara PG, Dissanayaka WL, Nanayakkara BG, Amaratunga EA, Tilakaratne WM. Comparison of spatula and cytobrush cytological techniques in early detection of oral malignant and premalignant lesions: A prospective and blinded study. J Oral Pathol Med. 2016;45(4):268-74. PMid:26403502 DOI:

Sreedhar G, Sumalatha MN, Shukla D. An overview of the risk factors associated with multiple oral premalignant lesions with a case report of extensive field cancerization in a female patient. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015;159(2):178-83. PMid:24401899 DOI:

Fernández PJ, Méndez-Sánchez SC, Gonzalez-Correa CA, Miranda DA. Could field cancerization be interpreted as a biochemical anomaly amplification due to transformed cells? Med Hypotheses. 2016;97:107-11. PMid:27876116 DOI:

Tanaka T, Tanaka M, Tanaka T. Oral carcinogenesis and oral cancer chemoprevention: A review. Pathol Res Int. 2011;2011:431246. PMid:21660266 DOI:




How to Cite

Alhatab N, Abusanna MM, Salih H. Assessment of Contralateral Biopsy Technique for Improving Tissue Changes in Patients with Tongue Malignancy. Open Access Maced J Med Sci [Internet]. 2021 Aug. 18 [cited 2023 Dec. 6];9(D):166-9. Available from: