The Differences in Transaminase Enzyme Levels among Children with Acute Diarrhea due to Rotavirus and Non-rotavirus

Samitha Wijaya; I Putu Gede Karyana; Eka Gunawijaya; Ida Bagus Subanada; I Gusti Agung Ngurah Sugitha Adnyana; Komang Ayu Witarini

doi:10.3889/oamjms.2021.6737

Authors

Samitha Wijaya Department of Child Health, Medical Faculty of Udayana University, Sanglah Hospital, Denpasar, Indonesia https://orcid.org/0000-0002-2123-8216
I Putu Gede Karyana Department of Child Health, Medical Faculty of Udayana University, Sanglah Hospital, Denpasar, Indonesia
Eka Gunawijaya Department of Child Health, Medical Faculty of Udayana University, Sanglah Hospital, Denpasar, Indonesia
Ida Bagus Subanada Department of Child Health, Medical Faculty of Udayana University, Sanglah Hospital, Denpasar, Indonesia
I Gusti Agung Ngurah Sugitha Adnyana Department of Child Health, Medical Faculty of Udayana University, Sanglah Hospital, Denpasar, Indonesia
Komang Ayu Witarini Department of Child Health, Medical Faculty of Udayana University, Udayana Hospital, Badung, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6737

Keywords:

Children, Diarrhea, Rotavirus, Non-rotavirus glutamic oxaloacetic transaminase, Glutamic pyruvic transaminase

Abstract

BACKGROUND: Diarrhea is the particular disease that still affects children in Indonesia, with rotavirus being the most common etiology among children under 5 years old. Rotavirus and non-rotavirus diarrhea can spread to the extraintestinal and localized to the liver which causes liver cell damage, thus, the level of the glutamic oxaloacetic and glutamic pyruvic transaminase enzymes increases.

AIM: The objective of the study was to prove that there are differences in serum levels of glutamic oxaloacetic and glutamic pyruvic transaminase in children with acute diarrhea due to rotavirus and non-rotavirus infection.

METHODS: This study used a cross-sectional design, the research subjects were children aged 6 months old until 60 months old with acute diarrhea in Denpasar Public Health Center, Sanglah, and Wangaya General Hospital within the period of March 2018 until March 2021. Statistical analysis used the Mann–Whitney.

RESULTS: A total of 70 subjects were analyzed in this study. There were 24.28% of subjects with rotavirus. Each group had nearly the same degree of severity of 29.4% for rotavirus and 30.2% for non-rotavirus, with a median of serum levels of glutamic oxaloacetic transaminase (SGOT) 47 (19–261) and glutamic pyruvic transaminase (SGPT) 25 (7–217). The results of this study showed that the median difference in aspartate aminotransferase and alanine aminotransferase levels was not significant in rotavirus and non-rotavirus diarrhea (SGOT 45 [16–168], 32 [11–261], p = 0.077; (SGPT 22 [14–91], 18 [5–217], p = 0.12).

CONCLUSION: This study concluded that there is a higher median level of SGOT and SGPT in children with acute diarrhea due to rotavirus infection compared to non-rotavirus infection, although it is not statistically significant.

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References

Akelma AZ, Kutukoglu I, Koksal T, Cizmech MN, Kanburoglu MK, Catal F, et al. Serum transaminase elevation in children with rotavirus gastroenteritis: Seven years’ experience. Scand J Infect Dis. 2013;45(5):262-67. https://doi.org/10.3109/00365548.2012.740573 PMid:23151057 DOI: https://doi.org/10.3109/00365548.2012.740573

Glass RI, Parashar UD, Bresee JS, Turcious R, Fisher TK, Widdowson MA, et al. Rotavirus vaccines: Current prospect and future challenges. Lancet. 2006;368(9532):323-32. https://doi.org/10.1016/s0140-6736(06)68815-6 PMid:16860702 DOI: https://doi.org/10.1016/S0140-6736(06)68815-6

Sunarto Y, Aman AT, Bakri A, Waluya H, Firmansyah A, Kadim M, et al. Burden of severe rotavirus in Indonesia. J Infect Dis. 2006;200 Suppl 1:S188-94. https://doi.org/10.1086/605338 PMid:19821711 DOI: https://doi.org/10.1086/605338

Kawashima H, Ishii C, Ioi H, Nishimata S, Kashiwagi Y, Takekuma K. Transaminase in rotavirus gastroenteritis. Pediatr Int. 2012;54(1):86-8. https://doi.org/10.1111/j.1442-200x.2011.03532.x PMid:22136601 DOI: https://doi.org/10.1111/j.1442-200X.2011.03532.x

Kucuk O, Ugras M, Bicer S, Col D, Giray T, Erdag GC, et al. Hypertransaminasaemia in children with viral gastroenteritis. Infez Med. 2016;24(1):32-7. PMid:27031894

Ramig RF. Pathogenesis of intestinal and systemic rotavirus infection. J Virol. 2004;78(19):10213-20. https://doi.org/10.1128/jvi.78.19.10213-10220.2004 PMid:15367586 DOI: https://doi.org/10.1128/JVI.78.19.10213-10220.2004

Karyana IP, Putra IG. Diare Akut. Dalam Pedoman Pelayanan Medis Kesehatan Anak. Denpasar: Bagian/SMF Ilmu Kesehatan Anak FK UNUD/RSUP Sanglah; 2011. https://doi.org/10.35790/ecl.4.2.2016.14678 DOI: https://doi.org/10.35790/ecl.4.2.2016.14678

Kang KS. Abnormality on liver function test. Pediatr Gastroenterol Hepatol Nutr. 2013;16(4):225-32. https://doi.org/10.5223/pghn.2013.16.4.225 PMid:24511518 DOI: https://doi.org/10.5223/pghn.2013.16.4.225

Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med. 2006;354(7):731-9. PMid:16481640

Soleimanpour H, Safari S, Rahmani F, Nejabatian A, Alavian SM. Hepatic shock differential diagnosis and risk factors: A review Article. Hepat Mon. 2015;15(10):e27063. https://doi.org/10.5812/hepatmon.27063 PMid:26587034 DOI: https://doi.org/10.5812/hepatmon.27063

Zhu Y, Zhang H, Sun Y, Li Y, Deng L, Wen X, et al. Serum enzyme profiles differentiate five types of muscular dystrophy. Dis Markers. 2015;2015:543282. https://doi.org/10.1155/2015/543282 PMid:26063958 DOI: https://doi.org/10.1155/2015/543282

Kementrian Kesehatan Republik Indonesia. Profil Kesehatan Indonesia Tahun 2015. 1st ed. Jakarta: Kementrian Kesehatan Republik Indonesia; 2016. https://doi.org/10.6066/jtip.2013.24.2.121

Taylor GH. Cytomegalovirus. Am Fam Physician. 2003;67(3):519-24. PMid:12588074

Kementerian Kesehatan Republik Indonesia. Pedoman Tatalaksana Infeksi HIV dan Terapi Antiretroviral pada Anak di Indonesia. 1st ed. Jakarta: Kementrian Kesehatan Republik Indonesia; 2014. https://doi.org/10.6066/jtip.2013.24.2.121 DOI: https://doi.org/10.6066/jtip.2013.24.2.121

World Health Organization. Generic Protocol for Monitoring Impact of Rotavirus Vaccination on Gastroenteritis Disease Burden and Viral Strains. 1st ed. Geneva: World Health Organization; 2008.

Anania C, de Luca E, de Castro G, Chiesa C, Pacifico L. Liver involvement in pediatric celiac disease. World J Gastroenterol. 2015;21(19):5813-22. https://doi.org/10.3748/wjg.v21.i19.5813 PMid:26019445 DOI: https://doi.org/10.3748/wjg.v21.i19.5813

Urayama S, Chang EB. Mechanisms and treatment of diarrhea in inflammatory bowel diseases. Inflamm Bowel Dis. 1997;3(2):114-31. https://doi.org/10.1002/ibd.3780030207 PMid:23282752 DOI: https://doi.org/10.1002/ibd.3780030207

Heil W, Ehrhardt V. Reference Range for Adults and Children Preanalytical Considerations. Switzerland: Roche Diagnostics GmbH; 2008. p. 14-24.

Vizzi E, Pineros O, Gonzalez GG, Zambrano JL, Ludert JE, Liprandi F. Genotyping of human rotaviruses circulating among children with diarrhea in Valencia, Venezuela. J Med Virol. 2011;83(12):2225-32. https://doi.org/10.1002/jmv.22211 PMid:22012733 DOI: https://doi.org/10.1002/jmv.22211

Greenberg HB, Estes MK. Rotaviruses: From pathogenesis to vaccination. Gastroenterology. 2009;136(6):1939-51. https://doi.org/10.1053/j.gastro.2009.02.076 PMid:19457420 DOI: https://doi.org/10.1053/j.gastro.2009.02.076

Kargar M, Jafarpour T, Najafi A. Epidemiological survey of Group A rotaviruses infection among children under 5 years with acute diarrhea. Zahedan J Res Med Sci. 2012;14(8):43-7.

Teitelbaum JE, Daghistani R. Rotavirus causes hepatic transaminase elevation. Dig Dis Sci. 2007;52(12):3396-8. https://doi.org/10.1007/s10620-007-9743-2 PMid:17431773 DOI: https://doi.org/10.1007/s10620-007-9743-2