Associated Factors of the Results of Pulmonary Tuberculosis Treatment During the COVID-19 Pandemic in Makassar City

Syahridha Syahridha; Nasrum  Massi; Ahyar  Ahmad; Irawaty  Djaharuddin

doi:10.3889/oamjms.2021.6742

Authors

Syahridha Syahridha Department of Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Nasrum Massi Department of Microbiology
Ahyar Ahmad Department of Chemistry, Mathematics and Natural Science Faculty, Hasanuddin University, Makassar, Indonesia
Irawaty Djaharuddin Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6742

Keywords:

Treatment outcomes, Pulmonary tuberculosis, COVID-19 pandemic

Abstract

BACKGROUND: A regimen directly observed treatment-short course is recommended by the World Health Organization as a strategy for controlling tuberculosis (TB).

AIM: This treatment was carried out for 6 months despite the COVID-19 pandemic situation. The purpose of the study was to determine the factors associated with the treatment outcomes of pulmonary TB undergoing treatment during the COVID-19 pandemic, with the research target was Category I pulmonary TB patients.

METHOD: The type of research was observational analytic with a cohort study design. This research was conducted at the Pulmonary Center in October 2020-May 2021 involved 62 samples.

RESULTS: About 75.8% (47 respondents) successfully treated and 24.2% (15 respondents) decided unsuccessful. There was a significant association between diabetes status (p = 0.014), anemia status (p = 0.035), knowledge of TB (p = 0.009), knowledge of COVID-19 (p = 0.014), and family history of COVID-19 exposure (p = 0.011) to the treatment outcomes of pulmonary TB treatment during the pandemic.

CONCLUSION: Associated factors to the outcome of treatment for pulmonary TB patients undergoing TB treatment during a pandemic included diabetes mellitus status, anemia status, knowledge of TB, knowledge of COVID-19, and family history of exposure to COVID-19.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Ali SA, Mavundla TR, Fantu R, Awoke T. Outcomes of TB treatment in HIV co-infected TB patients in Ethiopia: A cross-sectional analytic study. BMC Infect Dis. 2016;16(1):640. https://doi.org/10.1186/s12879-016-1967-3 Mid:27814693 DOI: https://doi.org/10.1186/s12879-016-1967-3

World Health Organization. Global Tuberculosis Report. Geneva: World Health Organization; 2020.

Kementerian Kesehatan RI. Pedoman Nasional Penanggulangan Tuberkulosis. Jakarta: Kementerian Kesehatan RI; 2014.

World Health Organization. Global Tuberculosis Report: Executive Summary. Geneva: World Health Organization; 2019.

Orooj M, Sharma B, Rabra S, Awasth S. Impact of COVID-19 pandemic on quality of life and medication adherence among pulmonary Tb patients. Int J Curr Res Rev. 2021;13(6):119-24. https://doi.org/10.31782/ijcrr.2021.sp186 DOI: https://doi.org/10.31782/IJCRR.2021.SP186

Rdos SL, Suffys P, Barroso EC, Kerr LR, Duarte CR, Freitas MV, et al. Genotyping and drug resistance patterns of Mycobacterium tuberculosis strains observed in a tuberculosis high-burden municipality in Northeast, Brazil. Braz J Infect Dis. 2013;17(3):338-45. https://doi.org/10.1016/j.bjid.2012.10.019 DOI: https://doi.org/10.1016/j.bjid.2012.10.019

Rao J. QRS for BDS II Year. Amsterdam, Netherlands: Elsevier Health Sciences; 2014.

Sulis G, Centis R, Sotgiu G, D’Ambrosio L, Pontali E, Spanevello A, et al. Recent developments in the diagnosis and management of tuberculosis. NPJ Prim Care Respir Med. 2016;26:16078. https://doi.org/10.1038/npjpcrm.2016.78 PMid:27808163 DOI: https://doi.org/10.1038/npjpcrm.2016.78

Sia IG, Wieland ML. Current concepts in the management of tuberculosis. Mayo Clin Proc. 2011;86(4):348-61. PMid:21454737 DOI: https://doi.org/10.4065/mcp.2010.0820

Ali MK, Karanja S, Karama M. Factors associated with tuberculosis treatment outcomes among tuberculosis patients attending tuberculosis treatment centres in 2016-2017 in Mogadishu, Somalia. Pan Afr Med J. 2017;28:197. PMid:29610635

Jaber AA, Khan AH, Sulaiman SA. Evaluating treatment outcomes and durations among cases of smear-positive pulmonary tuberculosis in Yemen: A prospective follow-up study. J Pharm Policy Pract. 2017;10:36. https://doi.org/10.1186/s40545-017-0124-8 PMid:29214026 DOI: https://doi.org/10.1186/s40545-017-0124-8

World Health Organization. Treatment of Tuberculosis: Guidelines for Treatment of Drug-Susceptible Tuberculosis and Patient Care. Geneva: World Health Organization; 2017.

Feng JY, Huang SF, Ting WY, Chen YC, Lin YY, Huang RM, et al. Gender differences in treatment outcomes of tuberculosis patients in Taiwan: A prospective observational study. Clin Microbiol Infect. 2012;18(9):E331-7. PMid:22734962 DOI: https://doi.org/10.1111/j.1469-0691.2012.03931.x

Belo MT, Luiz RR, Hanson C, Selig L, Teixeira EG, Chalfoun T, Trajman A. Tuberculosis and gender in a priority city in the state of Rio de Janeiro, Brazil. J Bras Pneumol. 2010;36(5):621-5. https://doi.org/10.1590/s1806-37132010000500015 PMid:21085829 DOI: https://doi.org/10.1590/S1806-37132010000500015

Dooley KE, Chaisson RE. Tuberculosis and diabetes mellitus: Convergence of two epidemics Lancet Infect Dis. 2009;9(12):737-46. https://doi.org/10.1016/s1473-3099(09)70282-8 PMid:19926034 DOI: https://doi.org/10.1016/S1473-3099(09)70282-8

Minchella PA, Donkor S, Owolabi O, Sutherland JS, McDermid JM. Complex anemia in tuberculosis: The need to consider causes and timing when designing interventions. Clin Infect Dis. 2015;60(5):764-72. https://doi.org/10.1093/cid/ciu945 PMid:25428413 DOI: https://doi.org/10.1093/cid/ciu945

Saathoff E, Villamor E, Mugusi F, Bosch RJ, Urassa W, Fawzi WW. Anemia in adults with tuberculosis is associated with HIV and anthropometric status in dar es Salaam, Tanzania. Int J Tuberc Lung Dis. 2011;15(7):925-32. https://doi.org/10.5588/ ijtld.10.0477 PMid:21682966 DOI: https://doi.org/10.5588/ijtld.10.0477

Nagu TJ, Spiegelman D, Hertzmark E, Aboud S, Makani J, Matee MI, et al. “Anemia at the initiation of tuberculosis therapy is associated with delayed sputum conversion among pulmonary tuberculosis patients in dar-es-salaam, Tanzania. PLoS One. 2014;9(3):e91229. https://doi.org/10.1371/journal.pone.0091229 PMid:24642636 DOI: https://doi.org/10.1371/journal.pone.0091229

Alene KA, Viney K, Gray DJ, McBryde ES, Wagnew M, Clements AC. Mapping tuberculosis treatment outcomes in Ethiopia. BMC Infect Dis. 2019;19(1):474. https://doi.org/10.1186/s12879-019-4099-8 PMid:31138129 DOI: https://doi.org/10.1186/s12879-019-4099-8

Jain VK, Iyengar KP, Samy DA, Vaishya R. Tuberculosis in the era of COVID-19 in India. Diabetes Metab Syndr. 2020;14(5):1439-43. https://doi.org/10.1016/j.dsx.2020.07.034 PMid:32755848 DOI: https://doi.org/10.1016/j.dsx.2020.07.034

Togun T, Kampmann B, Stoker NG, Lipman M. Anticipating the impact of the COVID-19 pandemic on TB patients and TB control programmes Ann Clin Microbiol Antimicrob. 2020;19(1):21. https://doi.org/10.1186/s12941-020-00363-1 PMid:32446305 DOI: https://doi.org/10.1186/s12941-020-00363-1