Amelioration of Cisplatin-induced Liver Injury by Extract Ethanol of Pometia pinnata
DOI:
https://doi.org/10.3889/oamjms.2021.6785Keywords:
Cisplatin, Pometia pinnata, LiverAbstract
BACKGROUND: Cisplatin use in clinical practice has been associated with an increase in aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, and lactate dehydrogenase (LDH).
AIM: The aim of this study is to determine the hepatoprotective activity of extract ethanol Pometia pinnata on rats induced Cisplatin.
MATERIALS AND METHODS: Thirty rats were separated into six groups (five rats). Group I was received only carboxy methyl cellulose. Group II was received a 7 mg/kgbw Cisplatin injection on day 3. Group III-VI were extract groups (Vitamin C 1%, 100 mg/kgbb, 200 mg/kgbb, and 400 mg/kgbb) administered orally from day 1 to 7, followed by Cisplatin injection on day 3. On day 8, rats were injected with 1% ketamine, open the chest and draw blood directly from the heart and centrifugated 5000 RPM (10–15 min), take the supernatant layer for analysis AST, ALT, total protein, and LDH levels.
RESULTS: The effect of extract ethanol of P. pinnata on liver injury biochemical markers AST, ALT, LDH, and total protein. Group negative had a significant increase (p < 0.05) in comparison to the normal that did not receive extract or Cisplatin. Meanwhile, there was a drop in biochemical parameters in the group given the extract in groups dose 100, 200, 400 mg/kgbw. Group VI of biochemical parameters statistically there is no significant different with group normal group (p > 0.05) that showing P. pinnata extract has hepatoprotective activity.
CONCLUSION: In summary, extract ethanol of P. pinnata has hepatoprotective effect by reducing the level of AST, ALT, total protein, and LDH levels.Downloads
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Copyright (c) 2021 Adrian Adrian, Rony Abdi Syahputra, Sukirman Lie, Sony Eka Nugraha (Author)
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