Bronchial Asthma: Genetic Factors Contributing to its Pathogenesis

Inna  Krynytska; Mariya Marushchak; Anna  Mykolenko; Iryna  Smachylo; Olha  Sopel; Svitlana  Kucher

doi:10.3889/oamjms.2021.6788

Authors

Inna Krynytska Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine https://orcid.org/0000-0002-0398-8937
Mariya Marushchak Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine https://orcid.org/0000-0001-6754-0026
Anna Mykolenko Department of Pathological Anatomy, Autopsy course and Forensic pathology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine https://orcid.org/0000-0002-1845-4882
Iryna Smachylo Department of Internal Medicine N1, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine https://orcid.org/0000-0003-4323-8628
Olha Sopel Department of General Hygiene and Ecology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine https://orcid.org/0000-0003-3807-1317
Svitlana Kucher Department of Internal Medicine Propedeutics and Phthisiology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine https://orcid.org/0000-0003-1026-9567

DOI:

https://doi.org/10.3889/oamjms.2021.6788

Keywords:

Bronchial asthma, Genes, Pathogenesis

Abstract

Researching bronchial asthma (BA)-linked gene polymorphisms can help to clarify heterogeneity of the disease and estimate its severity, which, in turn, will aid in developing an appropriate treatment corresponding to the patient’s unique asthma pathogenesis. The aim of presented review is to analyze the published data on the genetic preconditions of BA and the possible role of different genes polymorphisms in its pathogenesis. We have found that despite the fact that numerous genes are involved in the pathogenesis of BA and their polymorphisms are associated with increased risks for BA, it is important to understand that a combination of factors, both genetic and environmental, triggers BA development and determines its progression. On the other hand, the identification of BA susceptibility genes contributing to asthma pathogenesis and treatment response is the first step toward the development of personalized medicine.

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