The Effect of Calendarized Drug Package on Patients Compliance with Antibiotics
DOI:
https://doi.org/10.3889/oamjms.2021.6798Keywords:
Calendarized package, Compliance, Antibiotics, Pill count, Community health centerAbstract
BACKGROUND: Patients’ compliance with antibiotics has been one of the global challenges in combating antibiotics resistance. Patients will tend to forget their antibiotics, especially when they feel better. Related to this phenomenon, the development of medication reminder media is essential.
AIM: This experimental study was aimed to develop and apply calendarized package as a medication reminder media in patients with short-course antibiotics to improve their compliance.
METHODS: Calendarized package was prepared from the labeling of the original package of antibiotics with stickers. Patients above 18 years old who were prescribed short-course oral antibiotics (not more than 7 days) during the study period were asked to participate in this study. Patients were grouped into two groups (control and intervention group). Patients’ demographical data, medications prescribed, and the last antibiotics course day was recorded. Patients were then contacted for compliance evaluation on the latest antibiotics course day.
RESULTS: A total of 150 patients who met the inclusion criteria were recruited in this study. Seventy-six patients were grouped into the intervention group, while the remaining 74 patients were the control group. The results showed that the number of compliant patients in the intervention group was higher (72.37%) than those in the control group (45.95%), respectively (p < 0.000).
CONCLUSION: The application of the calendar on the package indicates the positive impact on the patients’ compliance with antibiotics. However, in this study, the compliance measurement was conducted indirectly because of the coronavirus disease 2019 pandemic. However, several limitations should be considered. Future research using a bigger sample size and stricter compliance measurement method is needed to confirm this finding.Downloads
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References
Wattiheluw MH, Herawati F, Setiasih S, Yulia R. Correlation of knowledge and beliefs to adherence with antibiotic use in adult patients at a private hospital in sidoarjo. Kesmas Natl Public Health J. 2020;15(2):99-104. https://doi.org/10.21109/kesmas.v15i2.2409 DOI: https://doi.org/10.21109/kesmas.v15i2.2409
World Health Organization. High Levels of Antibiotic Resistance Found Worldwide, New Data Shows. Geneva: World Health Organization; 2018.
Llor C, Bjerrum L. Antimicrobial resistance: Risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf. 2014;5(6):229-41. https://doi.org/10.1177/2042098614554919 PMid:25436105 DOI: https://doi.org/10.1177/2042098614554919
Tong S, Pan J, Lu S, Tang J. Patient compliance with antimicrobial drugs: A Chinese survey. Am J Infect Control. 2018;46(4):e25-9. https://doi.org/10.1016/j.ajic.2018.01.008 PMid:29592834 DOI: https://doi.org/10.1016/j.ajic.2018.01.008
Wibowo R, Soedibyo S. Kepatuhan berobat dengan antibiotik jangka pendek di poliklinik umum departemen ilmu kesehatan anak rumah sakit Dr. cipto mangunkusumo, Jakarta. Sari Pediatri. 2016;10(3):171. https://doi.org/10.14238/sp10.3.2008.171-6 DOI: https://doi.org/10.14238/sp10.3.2008.171-6
Zedler BK, Joyce A, Murrelle L, Kakad P, Harpe SE. A pharmacoepidemiologic analysis of the impact of calendar packaging on adherence to self-administered medications for long-term use. Clin Ther. 2011;33(5):581-97. https://doi.org/10.1016/j.clinthera.2011.04.020 DOI: https://doi.org/10.1016/j.clinthera.2011.04.020
Dupclay L, Eaddy M, Jackson J, Raju A, Shim A. Real-world impact of reminder packaging on antihypertensive treatment adherence and persistence. Patient Prefer Adherence. 2012;6:499-507. https://doi.org/10.2147/ppa.s31417 PMid:22927746 DOI: https://doi.org/10.2147/PPA.S31417
Sammulia SF, Rahmawati F, Andayani TM. Comparative Pill Box and Medication Chart on The Levels Compliance and Clinical Outcome in Elderly Patients at Batam. J Manag Pharm Pract. 2016;6(4):288. https://doi.org/10.22146/jmpf.358 DOI: https://doi.org/10.22146/jmpf.358
Khoiriyyah A, Ediati A. Pengaruh buku harian untuk meningkatkan kepatuhan pada pasien hipertensi: Studi kuasi eksperimen pada pasien hipertensi. J Empati. 2015;4(1):35-42. https://doi.org/10.53475/jicm.v3i1.74 DOI: https://doi.org/10.53475/jicm.v3i1.74
Muljabar SM, Supadmi W. The Influence of Giving Drug Information to Level Compliance for Antibiotic Used in Patients of Acute Respiratory Infection at Community Health Centre Kotagede I Yogyakarta. Pharmaciana. 2014;4(2):143-9. https://doi.org/10.12928/pharmaciana.v4i2.1571 DOI: https://doi.org/10.12928/pharmaciana.v4i2.1571
Naibobe DM, Rengga MP. The Effect of Counseling on The Adherence of Antibiotic Used in Acute Respiratory Infection (ARI) Patients at Sikumana Public Health Center. CHMK Pharm Sci J. 2020;3(2):133-7. https://doi.org/10.51352/jim.v4i1.134 DOI: https://doi.org/10.51352/jim.v4i1.134
Lee JK, Grace KA, Foster TG, Crawley MJ, Erowele GI, Sun HJ, et al. How should we measure medication adherence in clinical trials and practice? Ther Clin Risk Manag. 2007;3(4):685-90. PMid:18472991
Fernandes M, Leite A, Basto M, Nobre MA, Vieira N, Fernandes R, et al. Non-adherence to antibiotic therapy in patients visiting community pharmacies. Int J Clin Pharm. 2014;36(1):86-91. https://doi.org/10.1007/s11096-013-9850-4 PMid:24101031 DOI: https://doi.org/10.1007/s11096-013-9850-4
Schneider PJ, Murphy JE, Pedersen CA. Impact of medication packaging on adherence and treatment outcomes in older ambulatory patients. J Am Pharm Assoc (2003). 2008;48(1):58-63. PMid:18192132 DOI: https://doi.org/10.1331/JAPhA.2008.07040
Ahmed NJ. The rate of adherence to antibiotics and reasons for non-adherence among the public. J Pharm Res Int. 2020;32(7):42-7. https://doi.org/10.9734/jpri/2020/v32i730458 DOI: https://doi.org/10.9734/jpri/2020/v32i730458
Kandrotaite K, Smigelskas K, Janusauskiene D, Jievaltas M, Maciulaitis R, Briedis V. Development of a short questionnaire to identify the risk of nonadherence to antibiotic treatment. Curr Med Res Opin. 2013;29(11):1555-63. https://doi.org/10.1185/03007995.2013.835255 PMid:23952367 DOI: https://doi.org/10.1185/03007995.2013.835255
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Copyright (c) 2021 Ilil Maidatuz Zulfa, Widya Handayani (Author)
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