Negative Correlation between Serum Brain-derived Neurotrophic Factor Levels and Obesity Predictor Markers and Inflammation Levels in Females with Obesity


  • Slamet Raharjo Department of Sports Science, Faculty of Sports Science, State University of Malang, Malang, Indonesia
  • Adi Pranoto Department of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
  • Purwo Sri Rejeki Department of Physiology and Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
  • Ahmad Syahru Mubarok Harisman Department of Sports Science, Faculty of Sports Science, State University of Malang, Malang, Indonesia
  • Yualita Putri Pamungkas Department of Public Health, Faculty of Sports Science, State University of Malang, Malang, Indonesia
  • Olivia Andiana Department of Sports Science, Faculty of Sports Science, State University of Malang, Malang, Indonesia



Obesity, Brain-derived neurotrophic factor, Body mass index, Waist hip ratio, Interleukin-6, Tumor necrosis factor-α


BACKGROUND: Obesity has been widely associated with structural and functional changes in the brain, whereas inflammation is one of the potential mechanisms involved in these changes.

OBJECTIVE: This study aims to prove the relationship between serum brain-derived neurotrophic factor (BDNF) levels and obesity predictor markers (body mass index and waist to hip ratio) and inflammation (interleukin-6 and Tumor Necrosis Factor-alpha) levels in females with obesity.

METHODS: This study used a cross-sectional study method using 33 females with obesity aged 19-23 years, body mass index (BMI) > 27.5 kg/m2, normal blood pressure, normal resting heart rate (RHR), normal hemoglobin (Hb), and fasting blood glucose (FBG) ≤ 100 mg/dL. The examination of serum BDNF, IL-6, and TNF-α levels using the Enzyme-Linked Immunosorbent Assay (ELISA) method. The data were analyzed using Pearson product-moment test with a significant levels p<0.05.

RESULTS: The results indicated that there is a negative correlation between serum BDNF levels and BMI (r = –0.759; p<0.001), WHR (r = –0.675; p<0.001), IL-6 levels (r = –0.530; p<0.001) and TNF-α levels (r = –0.561; p<0.001).

CONCLUSION: Based on the results of the study, there is a negative correlation between serum BDNF levels and BMI, waist to hip ratio, and inflammation (interleukin-6 and Tumor Necrosis Factor-alpha) levels in females with obesity. Further studies are needed to confirm the present findings.


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How to Cite

Raharjo S, Pranoto A, Rejeki PS, Harisman ASM, Pamungkas YP, Andiana O. Negative Correlation between Serum Brain-derived Neurotrophic Factor Levels and Obesity Predictor Markers and Inflammation Levels in Females with Obesity. Open Access Maced J Med Sci [Internet]. 2021 Sep. 30 [cited 2022 Jan. 24];9(B):1021-6. Available from: