The Risk of Antihypertensive Drug among Breast Cancer Patient: A Systematic Review and Meta-analysis

Authors

  • Sinta Wiranata Medical Student, Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia https://orcid.org/0000-0001-5364-1969
  • Ida Ayu Widya Anjani Medical Student, Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia
  • Putri Ayu Wulandari Medical Student, Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia
  • Anak Agung Bagus Putra Indrakusuma Medical Student, Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia
  • I Gede Krisna Arim Sadeva Medical Student, Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia
  • Ayu Dilia Febriani Wisnawa Medical Student, Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia
  • Jonny Karunia Fajar Department of Internal Medicine, Brawijaya Internal Medicine Research Center, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia
  • I Putu Yuda Prabawa Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia
  • Putu Anda Tusta Adiputra Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia
  • I Wayan Sudarsa Department of Surgery, Division of Surgical Oncology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia https://orcid.org/0000-0002-6581-7244
  • Anak Agung Wiradewi Lestari Department of Clinical Pathology, Faculty of Medicine, Universitas Udayana, Sanglah General Hospital, Denpasar, Bali, Indonesia
  • Desak Made Wihandani Department of Biochemistry, Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia https://orcid.org/0000-0003-4270-8552
  • I Gede Putu Supadmanaba Department of Biochemistry, Faculty of Medicine, Universitas Udayana, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6841

Keywords:

Breast cancer, Antihypertensive drugs, Risk factors

Abstract

BACKGROUNDS: Breast cancer or breast carcinoma is the most common type of malignancy in women globally. According to the previous studies that indicate the usage of antihypertensive drugs may become a risk factor of cancer (beta-blockers [BBs], calcium channel blockers [CCBs], and diuretics). Both angiotensin-converting enzymes inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), on the other hand, have been associated to an increased or decreased risk of breast cancer.

AIM: To compare each type of antihypertensive medicines as a risk factor for breast cancer, we did a systematic review and meta-analysis of current evidence.

METHODS: We utilized the terms “antihypertensive”, “anti-hypertensive”, “anti-hypertensive medications”, “breast cancer”, “risk”, “case control”, and “cohort” in PubMed, ScienceDirect, and Google Scholar databases.

RESULTS: Our data calculation found that the risk of antihypertensive drugs was significantly different in overall analysis (odds ratio [OR] = 0.59, 95% confidence interval [CI] = 0.42–0.83, p = 0.003). Five studies with 39.503 breast cancer patients and 372.037 controls were included in the ARBs user sub-group. Our results found significant different of antihypertensive drugs among breast cancer patient (OR = 1.47, 95% CI = 1.02–2.11 p = 0.04). Our data calculation also confirmed no significant different in antihypertensive drugs among breast cancer patient (OR = 1.07, 95% CI = 0.99–1.16, p = 0.09) in diuretics user, (OR = 1.08, 95% CI = 0.99–1.18, p = 0.08) in CCBs user, (OR = 1.11, 95% CI = 0.98–1.26, p = 0.09) in BBs user, and (OR = 1.27, 95% CI = 0.64–2.50, p = 0.50) in ACEIs user.

CONCLUSIONS: Although, the finding reveal that antihypertensive drugs (diuretics, CCBs, BBs, and ACEIs) in overall are significant for the risk of breast cancer and also found that ARBs have a low potential in the risk of breast cancer.

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Published

2021-09-28

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1.
Wiranata S, Anjani IAW, Wulandari PA, Indrakusuma AABP, Sadeva IGKA, Wisnawa ADF, Fajar JK, Prabawa IPY, Adiputra PAT, Sudarsa IW, Lestari AAW, Wihandani DM, Supadmanaba IGP. The Risk of Antihypertensive Drug among Breast Cancer Patient: A Systematic Review and Meta-analysis. Open Access Maced J Med Sci [Internet]. 2021 Sep. 28 [cited 2024 Apr. 25];9(F):327-34. Available from: https://oamjms.eu/index.php/mjms/article/view/6841

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Vol. 9 No. F (2021): F - Review Articles

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Meta-analytic Review Article

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Copyright (c) 2021 Sinta Wiranata, Ida Ayu Widya Anjani, Putri Ayu Wulandari, Anak Agung Bagus Putra Indrakusuma, I Gede Krisna Arim Sadeva, Ayu Dilia Febriani Wisnawa, Jonny Karunia Fajar, I Putu Yuda Prabawa, Putu Anda Tusta Adiputra, I Wayan Sudarsa, Anak Agung Wiradewi Lestari, Desak Made Wihandani, I Gede Putu Supadmanaba (Author)

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