Blast Cells Count Influences Bleeding Incidence in Acute Leukemia: Preliminary Study in South Kalimantan, Indonesia

Edward Kurnia Setiawan Limijadi; Qintani Cantika Ismail; Dwi Retnoningrum; Wivina Riza Devi; Anugrah Riansari

doi:10.3889/oamjms.2021.6860

Authors

Edward Kurnia Setiawan Limijadi Department of Clinical Pathology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
Qintani Cantika Ismail Department of Bachelor Degree, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
Dwi Retnoningrum Department of Clinical Pathology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
Wivina Riza Devi Department of Clinical Pathology, Ulin Hospital, Banjarmasin, South Kalimantan, Indonesia
Anugrah Riansari Department of Parasitology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6860

Keywords:

Acute, Leukemia, Blast cell count, Bleeding

Abstract

Background: Acute leukemia is a malignant disease involving hematopoietic tissue, characterized by abnormal blood cells in bone marrow or called blast cells. The most common complications of acute leukemia is bleeding. A high percentage of blasts has been reported to increase the risk of bleeding in acute leukemia. Preliminary study was needed to investigate relationship between blast cells count and bleeding incidence in acute leukemia.

Methods: Crosssectional study with observasional analytic in 18 adult subjects was conducted from November 2019 to March 2020 in Ulin Hospital Banjarmasin South Kalimantan. The data were taken from medical records of acute leukemia patients who met inclusion and exclusion criterias. Data analysis was using Fisher’s exact test.

Results: There were 7 men and 11 women in this study. Blast cells count in peripheral with cut off <50% was 9 (50%) and ≥50% was 9 (50%). It was same for blast cells count in bone marrow. Both of women and men mostly have bleeding in acute leukemia, and bleeding incidence in women is higher than men. Bleeding condition was happened both in peripheral and bone marrow blast cells count with cut of <50% and ≥50%. Significancy of relationship between blast cells count and bleeding incidence was 0.637.

Conclusion: There is no significant between blast cells count and the bleeding incidence in acute leukemia. Another parameters that could be influenced bleeding inceidence need to be investigate in acute leukemia.

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References

Dia Rofinda Z. Kelainan hemostasis pada leukemia. J Kesehat Andalas. 2012;1(2):68-74. https://doi.org/10.25077/jka.v1i2.40 DOI: https://doi.org/10.25077/jka.v1i2.40

Lagunas-Rangel FA, Chavez-Valencia V, Gomez-Guijosa MA, Cortes-Penagos C. Acute myeloid leukemia genetic alterations and their clinical prognosis. Int J Hematol Stem Cell Res. 2017;11(4):329-39. PMid:29340131

Hunger SP, Mullighan CG. Acute lymphoblastic leukemia in children. N Engl J Med. 2015;373(16):1541-52. PMid:26465987 DOI: https://doi.org/10.1056/NEJMra1400972

Saultz JN, Garzon R. Acute myeloid leukemia: A concise review. J Clin Med. 2016;5(3):33. PMid:26959069 DOI: https://doi.org/10.3390/jcm5030033

Angelescu S, Berbec NM, Colita A, Barbu D, Lupu AR. Value of multifaced approach diagnosis and classification of acute leukemias. Maedica (Buchar). 2012;7(3):254-60. PMid:23401730

Kim H, Lee JH, Choi SJ. Risk score model for fatal intracranial hemorrhage in acute leukemia. Leukemia. 2006;20(5):770-6. https://doi.org/10.1038/sj.leu.2404148 PMid:16525500 DOI: https://doi.org/10.1038/sj.leu.2404148

Sellar RS, Fraser L,Khwaja A, Gale RE, Marafioti T, Akarca A. Cell cycle status in AML blast cells from peripheral blood, bone marrow aspirates and trephines and implications for biological studies and treatment. Br J Haematol. 2016;174(2):275-9. https://doi.org/10.1111/bjh.14055 PMid:27061724 DOI: https://doi.org/10.1111/bjh.14055

Balmages A, Dinglasan J, Osborn MB. Severe intracranial hemorrhage at initial presentation of acute myelogenous leukemia. Clin Pract Cases Emerg Med. 2018;2(3):203-6. https://doi.org/10.5811/cpcem.2018.4.37881 PMid:30083633 DOI: https://doi.org/10.5811/cpcem.2018.4.37881

O’Donnell MR, Appelbaum FR, Baer MR, Byrd JC, Coutre SE, Damon LE, et al. Acute myeloid leukemia: Clinical practice guidelines in oncology. J Natl Compr Cancer Netw. 2006;4(1):16-36. https://doi.org/10.6004/jnccn.2006.0004 PMid:31200351 DOI: https://doi.org/10.6004/jnccn.2006.0004

Psaila B, Bussel JB. Differences in platelet function in patients with acute myeloid leukaemia and myelodysplasia compare. J Thromb Haemost. 2011;9(11):2302-10. PMid:21920014

Webert KE. The risk of bleeding in thrombocytopenic patients with acute myeloid leukemia. Haematologica. 2006;9:1530-7. PMid:17043016

Estey EH. Acute myeloid leukemia: 2019 update on risk-stratification and management. Am J Hematol. 2018;93(10):1267-91. https://doi.org/10.1002/ajh.25214 PMid:30328165 DOI: https://doi.org/10.1002/ajh.25214

Kelton JG, Powers P, Julian J, Boland V, Carter CJ, Gent M, et al. Sex related differences in platelet aggregation: Influence of the hematocrit. Blood J Am Soc Hematol. 2011;56(1):38-41. https://doi.org/10.1182/blood.v56.1.38.38 PMid:7388180 DOI: https://doi.org/10.1182/blood.V56.1.38.38

Bodur S, Ayaz Y, Topallar F, Erdem G, Gün I. Severe uterine hemorrhage as first manifestation of acute leukemia. Eastern J Med. 2011;16(1):62-5.