The Effectiveness of Autologous Serum and Single-dose Oral Doxycycline in the Treatment of Acne Vulgaris: A Pilot Clinical Trial

Authors

  • Muhammad Nasrum Massi Department of Clinical Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Muhlis Yunus Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia https://orcid.org/0000-0001-6550-6465
  • Anis Irawan Anwar Department of Dermatology and Venereology
  • Khairuddin Djawad Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Siswanto Wahab Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Rahmawati Minhajat Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Uleng Bahrun Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Ilhamjaya Patellongi Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
  • Gemini Alam Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia
  • Ni Nyoman Sri Budayanti Department of Clinical Microbiology, Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6874

Keywords:

Acne vulgaris, Doxycycline, Autologous serum

Abstract

Introduction: Acne vulgaris is a chronic inflammatory disease that occurs with various factors, both intrinsic and extrinsic. Treatment of choice can vary from topical, systemic or a combination of both depending on the degree of severity. Recently, treatment using products from human blood has been widely studied, including in the field of dermatology as it has a unique composition.

Objective: to assess the effectiveness of autologous serum and single-dose oral doxycycline in the treatment of acne vulgaris

Methods: this clinical trial compared two groups which received autologous serum only and autologous serum combined with single dose of oral 200 mg doxycycline, respectively. Photographic pictures and number of lesions (blackheads, papules, pustules) were compared before and after application using Wilcoxon test.

Results: A total of 20 participants participated in this study. Both treatment groups showed significant decrease in lesion count (p <0.01). However, the group which received autologous serum and single dose of oral doxycycline showed superior improvement of inflammatory acne lesions.

Conclusion: autologous serum and single dose of oral doxycycline was superior to autologous serum only in the treatment acne lesions.

Keywords: Acne Vulgaris, Doxycycline, Autologous Serum

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References

Engler D. Acne. S Afr Pharm J. 2016;83(10):27-34. DOI: https://doi.org/10.1007/s15016-016-5703-4

Fox L, Csongradi C, Aucamp M, du Plessis J, Gerber M. Treatment modalities for acne. Molecules. 2016;21(8):1063. http://doi.org/10.3390/molecules21081063 PMid:27529209 DOI: https://doi.org/10.3390/molecules21081063

Bhat YJ, Latief I, Hassan I. Update on etiopathogenesis and treatment of Acne. Indian J Dermatol Venereol Leprol. 2017;83(3):298-306. http://doi.org/10.4103/0378-6323.199581 PMid:28195079 DOI: https://doi.org/10.4103/0378-6323.199581

Thielitz A, Krautheim A, Gollnick H. Update in retinoid therapy of acne. Dermatol Ther. 2006;19(5):272-9. http://doi.org/10.1111/j.1529-8019.2006.00084.x PMid:17014482 DOI: https://doi.org/10.1111/j.1529-8019.2006.00084.x

Lynn DD, Umari T, Dunnick CA, Dellavalle RP. The epidemiology of acne vulgaris in late adolescence. Adolesc Health Med Ther. 2016;7:13-25. http://doi.org/10.2147/AHMT.S55832 PMid:26955297 DOI: https://doi.org/10.2147/AHMT.S55832

Pugashetti R, Shinkai K. Treatment of acne vulgaris in pregnant patients. Dermatol Ther. 2013;26(4):302-11. http://doi.org/10.1007/s40265-013-0060-0 PMid:23657872 DOI: https://doi.org/10.1111/dth.12077

Tan AU, Schlosser BJ, Paller AS. A review of diagnosis and treatment of acne in adult female patients. Int J Womens Dermatol. 2018;4(2):56-71. http://doi.org/10.1016/j.ijwd.2017.10.006 PMid:29872679 DOI: https://doi.org/10.1016/j.ijwd.2017.10.006

Langer C, Mahajan V. Platelet-rich plasma in dermatology. J K Sci. 2014;16(4):147-50.

Kelhälä HL, Palatsi R, Fyhrquist N, Lehtimäki S, Väyrynen JP, Kallioinen M, et al. IL-17/Th17 pathway is activated in acne lesions. PLoS One. 2014;9(8):e105238. http://doi.org/10.1371/journal.pone.0105238 PMid:25153527 DOI: https://doi.org/10.1371/journal.pone.0105238

Shaw JC. Acne: Effect of hormones on pathogenesis and management. Am J Clin Dermatol. 2002;3(8):571-8. http://doi.org/10.2165/00128071-200203080-00007 PMid:12358558 DOI: https://doi.org/10.2165/00128071-200203080-00007

Sexton S. Acne vulgaris: Treatment guidelines from the AAD. J Am Acad Dermatol. 2016;74(5):945-73. DOI: https://doi.org/10.1016/j.jaad.2015.12.037

Kumar S, Mahajan BB, Kaur S, Singh A. Autologous therapies in dermatology. J Clin Aesthet Dermatol. 2014;7(12):38-45. PMid:25584137

Du R, Lei T. Effects of autologous platelet-rich plasma injections on facial skin rejuvenation. Exp Ther Med. 2020;19(4):3024-30. http://doi.org/10.3892/etm.2020.8531 PMid:32256789 DOI: https://doi.org/10.3892/etm.2020.8531

Draelos ZD, Rheins LA, Wootten S, Kellar RS, Diller RB. Pilot study: Autologous platelet-rich plasma used in a topical cream for facial rejuvenation. J Cosmet Dermatol. 2019;18(5):1348-52. http://doi.org/10.1111/jocd.13088 PMid:31350798 DOI: https://doi.org/10.1111/jocd.13088

Amable PR, Carias RB, Teixeira MV, da Cruz Pacheco I, Corrêa do Amaral RJ, Granjeiro JM, et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Ther. 2013;4(3):67. http://doi.org/10.1186/scrt218 PMid:23759113 DOI: https://doi.org/10.1186/scrt218

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Published

2021-11-28

How to Cite

1.
Massi MN, Yunus M, Anwar AI, Djawad K, Wahab S, Minhajat R, Bahrun U, Patellongi I, Alam G, Budayanti NNS. The Effectiveness of Autologous Serum and Single-dose Oral Doxycycline in the Treatment of Acne Vulgaris: A Pilot Clinical Trial. Open Access Maced J Med Sci [Internet]. 2021 Nov. 28 [cited 2024 Jun. 15];9(B):1602-6. Available from: https://oamjms.eu/index.php/mjms/article/view/6874

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