The Effectiveness of Autologous Serum and Single-dose Oral Doxycycline in the Treatment of Acne Vulgaris: A Pilot Clinical Trial

Muhammad Nasrum  Massi; Muhlis Yunus; Anis Irawan Anwar; Khairuddin Djawad; Siswanto Wahab; Rahmawati   Minhajat; Uleng   Bahrun; Ilhamjaya   Patellongi; Gemini Alam; Ni Nyoman Sri   Budayanti

doi:10.3889/oamjms.2021.6874

Authors

Muhammad Nasrum Massi Department of Clinical Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Muhlis Yunus Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia https://orcid.org/0000-0001-6550-6465
Anis Irawan Anwar Department of Dermatology and Venereology
Khairuddin Djawad Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Siswanto Wahab Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Rahmawati Minhajat Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Uleng Bahrun Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Ilhamjaya Patellongi Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Gemini Alam Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia
Ni Nyoman Sri Budayanti Department of Clinical Microbiology, Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6874

Keywords:

Acne vulgaris, Doxycycline, Autologous serum

Abstract

Introduction: Acne vulgaris is a chronic inflammatory disease that occurs with various factors, both intrinsic and extrinsic. Treatment of choice can vary from topical, systemic or a combination of both depending on the degree of severity. Recently, treatment using products from human blood has been widely studied, including in the field of dermatology as it has a unique composition.

Objective: to assess the effectiveness of autologous serum and single-dose oral doxycycline in the treatment of acne vulgaris

Methods: this clinical trial compared two groups which received autologous serum only and autologous serum combined with single dose of oral 200 mg doxycycline, respectively. Photographic pictures and number of lesions (blackheads, papules, pustules) were compared before and after application using Wilcoxon test.

Results: A total of 20 participants participated in this study. Both treatment groups showed significant decrease in lesion count (p <0.01). However, the group which received autologous serum and single dose of oral doxycycline showed superior improvement of inflammatory acne lesions.

Conclusion: autologous serum and single dose of oral doxycycline was superior to autologous serum only in the treatment acne lesions.

Keywords: Acne Vulgaris, Doxycycline, Autologous Serum

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