Effect of Non-alcoholic Fatty Liver Disease on Some of Bone Biomarkers in Men

Dalal Al-Akabi; Faris S. Kata

doi:10.3889/oamjms.2021.6892

Authors

Dalal Al-Akabi Department of Medical Laboratory Techniques, Al-Kunooze University College, Basrah, Iraq https://orcid.org/0000-0003-2939-3621
Faris S. Kata Department of Biology, College of Education For Pure Sciences, University of Basrah, Basrah, Iraq

DOI:

https://doi.org/10.3889/oamjms.2021.6892

Keywords:

Non-alcoholic fatty liver disease, Osteocalcin, Sclerostin, Bone sialoprotein

Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is one of the common liver diseases worldwide that is not associated with alcohol consumption; it is a group of disorders caused by fat accumulation in the liver.

AIM: The research aims to assess the levels of serum sialoprotein, sclerostin, and osteocalcin in men with NAFLD.

METHODS: The current study was conducted in Basra city, Iraq in 2020, which includes 400 men with NAFLD, age ranges between (30 and 50) years, and 400 matched health men as controls, serum levels of study parameters were measured using the ELISA method.

RESULTS: The results showed a significant decrease in the levels of serum osteocalcin but a non-significant difference in sclerostin and bone sialoprotein in men with NAFLD comparing with the control group, also age and disease severity factors did not show any significant effect on study parameters in the patient’s group.

CONCLUSION: In conclusion, men with NAFLD may be prone to some disturbances in the bone health regardless of disease progression and age in Basrah city.

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