The Effect of Pumpkin Seeds Biscuits and Moringa Extract Supplementation on Hemoglobin, Ferritin, C-reactive protein, and Birth Outcome for Pregnant Women: A Systematic Review

Authors

  • Musaidah Musaidah Doctoral Student in Public Health, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
  • Atjo Wahyu Department of Public Health, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
  • Andi Zulkifli Abdullah Department of Public Health, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
  • Muhammad Syafar Department of Public Health, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
  • Veni Hadju Department of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
  • Aminuddin Syam Department of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6903

Keywords:

Pumpkin seed, Moringa, Nutritional status, Hemoglobin, Pregnancy outcomes

Abstract

BACKGROUND: According to the WHO data, 40% of maternal mortality in developing countries is related to anemia in pregnancy. Most anemia in pregnancy is caused by iron deficiency and acute bleeding, sometimes even the two interact. The incidence of anemia in pregnancy in Indonesia is quite high, which is around 67% of all pregnant women, with variations depending on each region. About 10–15% of pregnant women are classified as severe anemia which of course will affect the growth and development of the fetus in the womb. Most of the anemia in pregnant women occurs due to malnutrition.

AIM: The objective of the study was to review journals related to the effect of pumpkin seed biscuits and Moringa capsules on hemoglobin (Hb), ferritin, and C-reactive protein (CRP) levels in pregnant women and also the prevention of stunting.

METHODS: Study of literature by collecting relevant literature using online journal data based on PUBMED, Google Search, ELSEVIER, MDPI, DOAJ (Direct Directory of Open Access Journals), or from the bibliography of the articles being searched.

RESULTS: Supplementary food was given to pregnant women by giving pumpkin seeds and Moringa leaf extract impact on improving nutritional status, Hb, ferritin, and CRP levels in pregnant women, as well as preventing adverse pregnancy outcomes such as low birth weight.

CONCLUSION: The provision of pumpkin seed biscuits and Moringa leaf extract to pregnant women can affect Hb, ferritin, and CRP levels and can affect maternal nutritional status and affect pregnancy outcomes.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Di Renzo GC, Spano F, Giardina I, Brillo E, Clerici G, Roura LC. Iron deficiency anemia in pregnancy. Womens Health. 2015;11(6):891-900. https://doi.org/10.2217/whe.15.35 PMid:26404445

Hooda J, Shah A, Zhang L. Heme, an essential nutrient from dietary proteins, critically impacts diverse physiological and pathological processes. Nutrients. 2014;6(3):1080-102. https://doi.org/10.3390/nu6031080 PMid:24633395

Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Rev. 2009;23(3):95-104. https://doi.org/10.1016/j.blre.2008.08.001 PMid:18835072

Soltan SS. The protective effect of soybean, sesame, lentils, pumpkin seeds and molasses on iron deficiency anemia in rats. World Appl Sci J. 2013;23:795-807.

Putri AW, Pratitis A, Luthfiya L, Wahyuni S, Tarmali A. Faktor ibu terhadap kejadian bayi Berat Lahir Rendah. HIGEIA J Public Health Res Dev. 2019;3(1):55-62. https://doi.org/10.21109/kesmas.v1i3.304

Losong NH, Adriani M. Perbedaan Kadar hemoglobin, Asupan Zat Besi, dan Zinc pada Balita Stunting dan Non Stunting. Am Nutr. 2017;1(2):117-23. https://doi.org/10.20473/amnt.v1i2.2017.117-123

Heliyani HD. Pengembangan produk pangan berbahan baku labu kuning. J Peningkatan Daya Saing Pangan Tradisional. 2012;2(1):134-40.

Maiya M. Effect of supplementation with pumpkin seed oil versus pumpkin seeds on blood pressure and menopausal symptoms in non-hypertensive postmenopausal women. In: Dissertation: Department of Nutrition and Food Sciences College of Health Sciences, Denton, Texas; 2017.

Nery MR, Imelda C. The effects of malunggay (Moringa oleifera) leaves capsule supplements on high specificity C-reactive protein and hemoglobin A1c levels of diabetic patients in Ospital ng maynila medical center: A prospective cohort study. Philippine J Intern Med. 2015;53(4):1-10.

Kim MY, Kim EJ, Kim YN, Choi C, Lee BH. Comparison of the chemical compositions and nutritive values of various pumpkin (Cucurbitaceae) species and parts. Nutr Res Pract. 2012;6(1):21-7. https://doi.org/10.4162/nrp.2011.5.6.21 PMid:22413037

Syed QA, Akram M, Shukat R. Nutritional and therapeutic importance of the pumpkin seeds. Seed. 2019;21(2):15798-803.

Gohari AA, Farhoosh R, Haddad KM. Chemical composition and physicochemical properties of pumpkin seeds (Cucurbita pepo Subsp. pepo Var. Styriaka) grown in Iran. J Agric Sci Technol. 2011;13:135.

Richter D, Abarzua S, Chrobak M, Vrekoussis T, Weissenbacher T, Kuhn C, et al. Effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells. Nutr Cancer. 2013;65(5):739-45. https://doi.org/10.1080/01635581.2013.797000 PMid:23859042

Chelliah R, Ramakrishnan S, Antony U. Nutritional quality of Moringa oleifera for its bioactivity and antibacterial properties. Int Food Res J. 2017;24(2):825.

Naghii MR, Mofid M. Impact of daily consumption of iron fortified ready-to-eat cereal and pumpkin seed kernels (Cucurbita pepo) on serum iron in adult women. Biofactors. 2007;30(1):19-26. https://doi.org/10.1002/biof.5520300103 PMid:18198398

Resmi S, Latheef F, Vijayaraghavan. Effectiveness of amla, jaggery and pumpkin leaves extract on the level of haemoglobin, Vitamin C and iron among adolescent girls with iron deficiency anemia. Int J Pharm Sci Res. 2017;8(11):4812-7. https://doi.org/10.7897/2277-4343.084219

Abuelgassim AO, Al-Showayman SI. The effect of pumpkin (Cucurbita Pepo L) seeds and L-arginine supplementation on serum lipid concentrations in atherogenic rats. Afr J Tradit Complement Altern Med. 2012;9(1):131-7. https://doi.org/10.4314/ajtcam.v9i1.18 PMid:23983330

Nishimura M, Ohkawara T, Sato H, Takeda H, Nishihira J. Pumpkin seed oil extracted from Cucurbita maxima improves urinary disorder in human overactive bladder. J Tradit Complement Med. 2014;4(1):72-4. https://doi.org/10.4103/2225-4110.124355 PMid:24872936

Kanwal S, Raza S, Naseem K, Amjad M, Bibi N, Gillani M. Development, physico-chemical and sensory properties of biscuits supplemented with pumpkin seeds to combat childhood malnutrition in Pakistan. Pak J Agric Res. 2015;28(4):400-5.

Iskandar I, Hadju V, As’ad S, Natsir R. Effect of Moringa oleifera leaf extracts supplementation in preventing maternal anemia and low-birth-weight. Int J Sci Res Public 2015;5(2):1-3.

Suzana D, Suyatna FD, Andrajati R, Santi PS, Mun’im A. Effect of Moringa oleifera leaves extract against hematology and blood biochemical value of patients with iron deficiency anemia. J Young Pharm. 2017;9(1):S79. https://doi.org/10.5530/jyp.2017.1s.20

Sartika W, Suryarinilsih Y. The Effect of Moringa Leaf Capsule On the Hemoglobin Levels in Young Women at Smp Sabbihisma Padang. United States: KnE Life Sciences; 2019. p. 158-64. https://doi.org/10.18502/kls.v4i15.5753

Sihotang PC, Candriasih P, Amdadi S. Effect of Moringa (Moringa oleifera) Biscuit administration on hemoglobin levels of pregnant women. Int J Sci Basic Appl Res. 2018;37(1):243-52.

Nurdin MS, Imam A, Thahir A, Hadju V. Supplementations on pregnant women and the potential of Moringa oleifera supplement to prevent adverse pregnancy outcome. Int J Sci Healthc Res. 2018;3(1):71-5.

Sindhu S, Mangala S, Sherry B. Efficacy of Moringa oleifera in treating iron deficiency anemia in women of reproductive age group. Int J Physiother Res. 2013;3(4):15-20.

Nadimin HV, As’ad S, Buchari A. The extract of Moringa leaf has an equivalent effect to iron folic acid in increasing hemoglobin levels of pregnant women: A randomized control study in the coastal area of Makassar. Int J Sci Basic Appl Res. 2015;22(1):287-94. https://doi.org/10.5958/0976-5506.2019.00102.5

Naghii MR, Mofid M. Impact of daily consumption of iron fortified ready-to-eat cereal and pumpkin seed kernels (Cucurbita pepo) on serum iron in adult women. Biofactors. 2007;30(1):19-26. Mid:18198398

Downloads

Published

2021-09-17

How to Cite

1.
Musaidah M, Wahyu A, Abdullah AZ, Syafar M, Hadju V, Syam A. The Effect of Pumpkin Seeds Biscuits and Moringa Extract Supplementation on Hemoglobin, Ferritin, C-reactive protein, and Birth Outcome for Pregnant Women: A Systematic Review. Open Access Maced J Med Sci [Internet]. 2021 Sep. 17 [cited 2022 Jan. 24];9(F):360-5. Available from: https://oamjms.eu/index.php/mjms/article/view/6903

Issue

Section

Systematic Review Article

Categories

Most read articles by the same author(s)

1 2 3 4 > >>