Effect of Hyaluronic Acid Gel on Healing of Simple Dental Extraction Sockets: A Pilot Study


  • Diana Mostafa Department of Clinical Periodontology and Oral Medicine, Faculty of Dentistry, Alexandria University, Alexandria, Egypt https://orcid.org/0000-0001-5653-1124
  • Maram Alzahrani Department of Preventive Dental Sciences, Vision Colleges, Riyadh, Saudi Arabia https://orcid.org/0000-0001-8817-4088
  • Jawharah Atiah Alatawi Department of Preventive Dental Sciences, Vision Colleges, Riyadh, Saudi Arabia
  • Samar Farhan Alsirhani Department of Preventive Dental Sciences, Vision Colleges, Riyadh, Saudi Arabia
  • Afrah Alshehri Department of Preventive Dental Sciences, Vision Colleges, Riyadh, Saudi Arabia https://orcid.org/0000-0001-7137-8770
  • Afnan Mazyed Almutiri Department of Preventive Dental Sciences, Vision Colleges, Riyadh, Saudi Arabia




Dental extraction, Hyaluronic acid, Healing of dental sockets, Pilot study, Bone repair


BACKGROUND: Hyaluronic acid (HA) was explored as a powerful positive biocompatible material that participates in numerous biological processes related to morphogenesis and tissue healing.

AIM: In this context, we elevated in this pilot study the effect of HA on soft tissue healing and bone repair of dental sockets (DS) as well as the postoperative pain.

MATERIALS AND METHODS: Ten individuals of both genders (80% females and 20% males) with age range 18–44 years, were included who were diagnosed with two non-restorable teeth (total sockets n = 20). A split-mouth study design was performed where the DS of each patient were divided into Group A (study group): Topical oral HA gel (Gengigel®) was applied into sockets while Group B (control group): Sockets were left untreated. Study variables were evaluated including socket length, socket healing scores (healing index), and post-operative pain in both groups at day 1, 5, and 10 for each patient.

RESULTS: There were no statistically significant differences between the control and study groups regarding the reduction of the socket length and postoperative complications but results revealed that HA enhances and fasten the healing capacity.

CONCLUSION: HA can be used as adjunctive treatment to improve the wound healing process.


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Bodic F, Hamel L, Lerouxel E, Baslé MF, Chappard D. Bone loss and teeth. Joint Bone Spine. 2005;72(3):215-21. https://doi.org/10.1016/j.jbspin.2004.03.007 PMid:15850992 DOI: https://doi.org/10.1016/j.jbspin.2004.03.007

Mendes RM, Silva GA, Lima MF, Calliari MV, Almeida AP, Alves JB, et al. Sodium hyaluronate accelerates the healing process in tooth sockets of rats. Arch Oral Biol. 2008;53(12):1155-62. https://doi.org/10.1016/j.archoralbio.2008.07.001 PMid:18692778 DOI: https://doi.org/10.1016/j.archoralbio.2008.07.001

Preetha S. An overview of dry socket and its management. IOSR J Dent Med Sci. 2014;13(5):32-5. DOI: https://doi.org/10.9790/0853-13523235

Sharif MO, Dawoud BE, Tsichlaki A, Yates JM. Interventions for the prevention of dry socket: An evidence-based update. Br Dent J. 2014;217(1):27-30. https://doi.org/10.1038/sj.bdj.2014.550 PMid:25012325 DOI: https://doi.org/10.1038/sj.bdj.2014.550

Prince CW. Roles of hyaluronan in bone resorption. BMC Musculoskelet Disord. 2004;5(1):12. PMid:15117412 DOI: https://doi.org/10.1186/1471-2474-5-12

Chen F, Ni Y, Liu B, Zhou T, Yu C, Su Y, et al. Self-crosslinking and injectable hyaluronic acid/RGD-functionalized pectin hydrogel for cartilage tissue engineering. Carbohydr Polym. 2017;166:31-44. https://doi.org/10.1016/j.carbpol.2017.02.059 PMid:28385238 DOI: https://doi.org/10.1016/j.carbpol.2017.02.059

Kim J, Kim IS, Cho TH, Lee KB, Hwang SJ, Tae G, et al. Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells. Biomaterials. 2007;28(10):1830-7. https://doi.org/10.1016/j.biomaterials.2006.11.050 PMid:17208295 DOI: https://doi.org/10.1016/j.biomaterials.2006.11.050

Pasquinelli G, Orrico C, Foroni L, Bonafè F, Carboni M, Guarnieri C, et al. Mesenchymal stem cell interaction with a non-woven hyaluronan-based scaffold suitable for tissue repair. J Anat. 2008;213(5):520-30. https://doi.org/10.1111/j.1469-7580.2008.00974.x PMid:19014359 DOI: https://doi.org/10.1111/j.1469-7580.2008.00974.x

Giavaresi G, Torricelli P, Fornasari PM, Giardino R, Barbucci R, Leone G. Blood vessel formation after soft-tissue implantation of hyaluronan-based hydrogel supplemented with copper ions. Biomaterials. 2005;26(16):3001-8. https://doi.org/10.1016/j.biomaterials.2004.08.027 PMid:15603795 DOI: https://doi.org/10.1016/j.biomaterials.2004.08.027

Landry RG, Turnbull RS, Howley T. Effectiveness of benzydamyne HCl in the treatment of periodontal post-surgical patients. Res Clin Forums. 1988;10:105-18.

Dahiya P, Kamal R. Hyaluronic acid: A boon in periodontal therapy. N Am J Med Sci. 2013;5(5):309-15. PMid:23814761 DOI: https://doi.org/10.4103/1947-2714.112473

de Brito Bezerra B, Brazão MA, de Campos ML, Casati MZ, Sallum EA, Sallum AW. Association of hyaluronic acid with a collagen scaffold may improve bone healing in critical-size bone defects. Clin Oral Implants Res. 2012;23(8):938-42. https://doi.org/10.1111/j.1600-0501.2011.02234.x PMid:21689163 DOI: https://doi.org/10.1111/j.1600-0501.2011.02234.x

Aslan M, Simsek G, Dayi E. The effect of hyaluronic acid-supplemented bone graft in bone healing: Experimental study in rabbits. J Biomater Appl. 2006;20(3):209-20. https://doi.org/10.1177/0885328206051047 PMid:16364962 DOI: https://doi.org/10.1177/0885328206051047

Suzuki K, Anada T, Miyazaki T, Miyatake N, Honda Y, Kishimoto KN, et al. Effect of addition of hyaluronic acids on the osteoconductivity and biodegradability of synthetic octacalcium phosphate. Acta Biomater. 2014;10(1):531-43. https://doi.org/10.1016/j.actbio.2013.09.005 PMid:24035888 DOI: https://doi.org/10.1016/j.actbio.2013.09.005

Yilmaz N, Demirtas N, Kazancioglu HO, Bayer S, Acar AH, Mihmanli A. The efficacy of hyaluronic acid in postextraction sockets of impacted third molars: A pilot study. Niger J Clin Pract. 2017;20(12):1626-31. PMid:29378998

Alcântara CE, Castro MA, Noronha MS, Martins-Junior PA, Mendes RM, Caliari MV, et al. Hyaluronic acid accelerates bone repair in human dental sockets: A randomized triple-blind clinical trial. Braz Oral Res. 2018;32:e84. https://doi.org/10.1590/1807-3107bor-2018.vol32.0084 PMid:30231173 DOI: https://doi.org/10.1590/1807-3107bor-2018.vol32.0084

Kawano Y, Patrulea V, Sublet E, Borchard G, Iyoda T, Kageyama R, et al. Wound healing promotion by hyaluronic acid: Effect of molecular weight on gene expression and in vivo wound closure. Pharmaceuticals (Basel). 2021;14(4):301. https://doi.org/10.3390/ph14040301 PMid:33800588 DOI: https://doi.org/10.3390/ph14040301

Yazan M, Kocyigit ID, Atil F, Tekin U, Gonen ZB, Onder ME. Effect of hyaluronic acid on the osseointegration of dental implants. Br J Oral Maxillofac Surg. 2019;57(1):53-7. https://doi.org/10.1016/j.bjoms.2018.08.014 PMid:30558816 DOI: https://doi.org/10.1016/j.bjoms.2018.08.014

Mostafa M, Shamma BD, Ayad SS, El-Dibany RM, Nagui DA. Evaluation of the effect of hyaluronic acid mixed with biphasic calcium phosphate on bone healing around dental implants (experimental study). Alex Dent J. 2017;42(1):104-11. https://doi.org/10.21608/adjalexu.2017.57868 DOI: https://doi.org/10.21608/adjalexu.2017.57868

Aebli N, Stich H, Schawalder P, Theis JC, Krebs J. Effects of bone morphogenetic protein-2 and hyaluronic acid on the osseointegration of hydroxyapatite-coated implants: An experimental study in sheep. J Biomed Mater Res A. 2005;73(3):295-302. https://doi.org/10.1002/jbm.a.30299 PMid:15834931 DOI: https://doi.org/10.1002/jbm.a.30299

Brokelman RB, Haverkamp D, van Loon C. The validation of the visual analogue scale for patient satisfaction after total hip arthroplasty. Eur Orthop Traumatol. 2012;3(2):101-5. https://doi.org/10.1007/s12570-012-0100-3 PMid:22798966 DOI: https://doi.org/10.1007/s12570-012-0100-3

Bayoumi AM, Jan A, Amoudi WA, Shakir M. The effects of using hyaluronic acid on the extraction sockets. Int J Dent Oral Health. 2015;2(1):1-5. DOI: https://doi.org/10.16966/2378-7090.157

Koray M, Ofluoglu D, Onal EA, Ozgul M, Ersev H, Yaltirik M, et al. Efficacy of hyaluronic acid spray on swelling, pain, and trismus after surgical extraction of impacted mandibular third molars. Int J Oral Maxillofac Surg. 2014;43(11):1399-403. https://doi.org/10.1016/j.ijom.2014.05.003 PMid:24924267 DOI: https://doi.org/10.1016/j.ijom.2014.05.003




How to Cite

Mostafa D, Alzahrani M, Alatawi JA, Alsirhani SF, Alshehri A, Mazyed Almutiri A. Effect of Hyaluronic Acid Gel on Healing of Simple Dental Extraction Sockets: A Pilot Study. Open Access Maced J Med Sci [Internet]. 2021 Sep. 3 [cited 2023 May 31];9(D):190-5. Available from: https://oamjms.eu/index.php/mjms/article/view/6913