Effect of Hyaluronic Acid Gel on Healing of Simple Dental Extraction Sockets: A Pilot Study


  • Diana Mostafa Department of Clinical Periodontology and Oral Medicine, Faculty of Dentistry, Alexandria University, Alexandria, Egypt https://orcid.org/0000-0001-5653-1124
  • Maram Alzahrani Department of Preventive Dental Sciences, Vision Colleges, Riyadh, Saudi Arabia https://orcid.org/0000-0001-8817-4088
  • Jawharah Atiah Alatawi Department of Preventive Dental Sciences, Vision Colleges, Riyadh, Saudi Arabia
  • Samar Farhan Alsirhani Department of Preventive Dental Sciences, Vision Colleges, Riyadh, Saudi Arabia
  • Afrah Alshehri Department of Preventive Dental Sciences, Vision Colleges, Riyadh, Saudi Arabia https://orcid.org/0000-0001-7137-8770
  • Afnan Mazyed Almutiri Department of Preventive Dental Sciences, Vision Colleges, Riyadh, Saudi Arabia




Dental extraction, Hyaluronic acid, Healing of dental sockets, Pilot study, Bone repair


BACKGROUND: Hyaluronic acid (HA) was explored as a powerful positive biocompatible material that participates in numerous biological processes related to morphogenesis and tissue healing.

AIM: In this context, we elevated in this pilot study the effect of HA on soft tissue healing and bone repair of dental sockets (DS) as well as the postoperative pain.

MATERIALS AND METHODS: Ten individuals of both genders (80% females and 20% males) with age range 18–44 years, were included who were diagnosed with two non-restorable teeth (total sockets n = 20). A split-mouth study design was performed where the DS of each patient were divided into Group A (study group): Topical oral HA gel (Gengigel®) was applied into sockets while Group B (control group): Sockets were left untreated. Study variables were evaluated including socket length, socket healing scores (healing index), and post-operative pain in both groups at day 1, 5, and 10 for each patient.

RESULTS: There were no statistically significant differences between the control and study groups regarding the reduction of the socket length and postoperative complications but results revealed that HA enhances and fasten the healing capacity.

CONCLUSION: HA can be used as adjunctive treatment to improve the wound healing process.


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How to Cite

Mostafa D, Alzahrani M, Alatawi JA, Alsirhani SF, Alshehri A, Mazyed Almutiri A. Effect of Hyaluronic Acid Gel on Healing of Simple Dental Extraction Sockets: A Pilot Study. Open Access Maced J Med Sci [Internet]. 2021 Sep. 3 [cited 2024 Jun. 17];9(D):190-5. Available from: https://oamjms.eu/index.php/mjms/article/view/6913