The Impact of Multiple Micronutrient Supplementation on Hemoglobin Concentration in Pregnant and Neonatal Birth Wight


  • Abdul Faris Department of Public Health, Universitas Hasanuddin, Makassar, Indonesia
  • Muhammad Tahir Abdullah Department of Public Health, Universitas Hasanuddin, Makassar, Indonesia
  • Veni Hadju Department of Nutrition, Universitas Hasanuddin, Makassar, Indonesia



Periconsepsional, Multiple micronutrient, Hemoglobin, Anemia, Low birth weight


Background: Anemia during pregnancy is a public health problem especially in developing countries and it is associated with maternal and perinatal adverse outcomes.  Global data shows that 56% of pregnant women in low- and middle-income countries have anemia. Every year more than 20 million infants are born with low birth weigh t(LBW) worldwide.

Objective: To analyze the impact of Multi Micronutrients (MM) supplementation on hemoglobin (Hb) levels of pregnant women and infant birth weight.

Method: The databases used to obtain the literature were PubMed, ScienceDirect, MEDLINE, and PubMed Central. The keywords used were Multiple Micronutrien Supplementation, Hemoglobin, Pregnant and Neonatal Birth Weght in studies published from 2010 to 2020. A total of 14 articles were used in this review.

Results: Seven articles obtained about the effects of multiple micronutrients on hemoglobin levels in pregnant women. Six studies support that MM supplementation increases hemoglobin levels or prevents pregnant women from anemia. One study showed a significant increase in serum ferritin One study reported ferritin levels in the MM group as well as the fe-folic acid group did not experience a significant decrease. There is only one study that shows the opposite results, which the mean maternal hemoglobin level significantly decreased during study, being the lowest in second trimester. Ferritin and serum iron levels were decreased at trimester one and two, also the zinc and vitamin D level declined. Seven articles show the effect of MM supplementation on pregnancy outcomes is better than Fe-folic acid supplementation. This can be seen in the results reported from various studies that have been carried out, which are reduce the incidence of LBW, small for gestational age, preterm labor. stillbirths, and NTD anomaly.

Conclusion: Various empirical evidence that has been described in this paper confirms the plausibility that the provision of micronutrient supplementation in the periconceptional period is more important than only given during advanced pregnancy. Multi micronutrient administration increases hemoglobin levels in pregnant women and improves pregnancy outcomes


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How to Cite

Faris A, Abdullah MT, Hadju V. The Impact of Multiple Micronutrient Supplementation on Hemoglobin Concentration in Pregnant and Neonatal Birth Wight. Open Access Maced J Med Sci [Internet]. 2021 Sep. 15 [cited 2021 Dec. 4];9(F):366-9. Available from:



Systematic Review Article


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