Impact of Obesity on Physical Activity

Authors

  • Titis Nurmasitoh Department of Physiology https://orcid.org/0000-0002-8201-5251
  • Umatul Khoiriyah Department of Medical Education, Faculty of Medicine, Universitas Islam Indonesia, Yogyakarta, Indonesia https://orcid.org/0000-0001-8645-8482
  • Ika Fidianingsih Department of Histology, Faculty of Medicine, Universitas Islam Indonesia, Yogyakarta, Indonesia https://orcid.org/0000-0002-1270-4545
  • Adika Zhulhi Arjana Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia https://orcid.org/0000-0003-2273-6548
  • Ninda Devita Magister of Biomedical Sciences, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.6965

Keywords:

Obesity, Dopamine, Exercise, Physical activity, Motivation

Abstract

BACKGROUND: Obesity occurs due to an imbalance between the calories and the energy released. On the animal model, obesity is considered as the ground for low physical activity. This is caused by low dopamine D2 receptor in the striatum. However, this suggestion is still unproven in the human condition.

AIM: The aim of this study was to find out difference in dopamine expression in obese subjects compared to non-obese subjects when triggered by the stimuli of physical activity.

METHODS: This is a quasi-experimental study. The sample was obese and non-obese (control) female who met inclusion and exclusion criteria. Before treatment was given, subjects were asked to fill out a depression, anxiety, and exercise motivation questionnaire. All subjects were tested for vital signs, anthropometrics, and neurological examinations to determine the initial condition. Then, the subjects saw video about physical activity and were taken for blood to measure blood dopamine levels using enzyme-linked immunosorbent assay. Differences in dopamine levels between the obese and control groups were analyzed using independent t-test. The relationship between dopamine levels and exercise motivation was analyzed using Pearson.

RESULTS: The obese group’s dopamine level was 71.19 ±3.02ng/ml and the control group was 81.15 ± 3.17ng/ml (independent t-test, p = 0.032). The obese group’s motivation score was 58.46 ± 1.59 and the control group score was 62.38 ± 1.54 (independent t-test, p = 0.09). Furthermore, there was no correlation between dopamine levels and motivation scores (Pearson test, p = 0.09).

CONCLUSION: There are significant differences in dopamine levels between the obese group and the control group but no correlation between dopamine levels and exercise motivation scores.

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Published

2021-11-17

How to Cite

1.
Nurmasitoh T, Khoiriyah U, Fidianingsih I, Arjana AZ, Devita N. Impact of Obesity on Physical Activity. Open Access Maced J Med Sci [Internet]. 2021 Nov. 17 [cited 2024 Nov. 21];9(A):988-92. Available from: https://oamjms.eu/index.php/mjms/article/view/6965