Assessment of Serum Ionized Calcium in the Perioperative Period in Patients Undergoing Total Thyroidectomy

Authors

  • Muqdad Fuad Department of Surgery, College of Medicine, University of Diyala, Baqubah, Iraq https://orcid.org/0000-0002-2433-2689
  • Ahmed Modher Department of Surgery, College of Medicine, University of Diyala, Baqubah, Iraq

DOI:

https://doi.org/10.3889/oamjms.2021.7018

Keywords:

Post-operative hypocalcemia, Thyroidectomy complications, Transient hypocalcemia

Abstract

BACKGROUND: The serious complications of total and near-total thyroidectomy vary from hypocalcemia to recurrent laryngeal nerve injury to tension hematoma. Post-operative hypocalcemia is common and has an incidence of 1.3–83% in some studies.

AIM: The aim of the study is to evaluate the immediate post-operative sequence of serum-ionized calcium next to entire or close entire thyroidectomy to describe the incidence degree of hypocalcemia.

METHOD: One hundred and seventy-four (174) patients who underwent total and near-total thyroidectomy were investigated for serum-ionized calcium level preoperatively and on post-operative day (POD) 1 and 2, searching for difference in serum-ionized calcium level preoperatively.

RESULTS: There was a significant difference between pre-operative serum-ionized calcium (Ca++) level and that in POD1. The mean pre-operative ionized Ca was 1.23 ± 0.47 mmol/l, while mean ionized Ca on POD1 was 1.175 ± 0.11 mmol/l proposing decrease in mean of ionized Ca++ in POD1 (p = 0.0001). There was also a significant difference between pre-operative serum-ionized Ca++ level and that in POD2. The mean pre-operative ionized Ca was 1.23 ± 0.47 mmol/l, while the mean of ionized calcium on POD2 was 1.177 ± 0.1 mmol/l suggesting decrease in mean concentration of Ca++ in POD2 (p = 0.0001).

CONCLUSION: Significant number of patients who undergo near-total and total thyroidectomy develop decrease in the serum concentration of calcium postoperatively.

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References

Grzegory A, Pomorski L. Perioperative calcium and Vitamin D supplementation in patients undergoing thyroidectomy literature review. Pol Przegl Chir. 2018;90(4):46-50. https://doi.org/10.5604/01.3001.0012.0975 PMid:30220675 DOI: https://doi.org/10.5604/01.3001.0012.0975

Harris AS, Prades E, Tkachuk O, Zeitoun H. Better consenting for thyroidectomy: Who has an increased risk of postoperative hypocalcaemia? Eur Arch Otorhinolaryngol. 2016;273(12):4437-43. https://doi.org/10.1007/s00405-016-4084-4 PMid:27207140 DOI: https://doi.org/10.1007/s00405-016-4084-4

Noureldine SI, Genther DJ, Lopez M, Agrawal N, Tufano RP. Early predictors of hypocalcemia after total thyroidectomy: An analysis of 304 patients using a short-stay monitoring protocol. JAMA Otolaryngol Head Neck Surg. 2014;140(11):1006-13. https://doi.org/10.1001/jamaoto.2014.2435 PMid:25321339 DOI: https://doi.org/10.1001/jamaoto.2014.2435

Lorente-Poch L, Sancho JJ, Ruiz S, Sitges-Serra A. Importance of in situ preservation of parathyroid glands during total thyroidectomy. Br J Surg. 2015;102(4):359-67. https://doi.org/10.1002/bjs.9676 Mid:25605285 DOI: https://doi.org/10.1002/bjs.9676

Mauriello C, Marte G, Canfora A, Napolitano S, Pezzolla A, Gambardella C, et al. Bilateral benign multinodular goiter: What is the adequate surgical therapy? A review of literature. Int J Surg. 2016;28 Suppl 1:S7-12. https://doi.org/10.1016/j.ijsu.2015.12.041 PMid:26708850 DOI: https://doi.org/10.1016/j.ijsu.2015.12.041

De Palma M, Rosato L, Zingone F, Orlando G, Antonino A, Vitale M, et al. Post-thyroidectomy complications. The role of the device: Bipolar vs ultrasonic device: Collection of data from 1,846 consecutive patients undergoing thyroidectomy. Am J Surg. 2016;212(1):116-21. https://doi.org/10.1016/j.amjsurg.2015.05.024 Mid:26349585 DOI: https://doi.org/10.1016/j.amjsurg.2015.05.024

Sands NB, Payne RJ, Côté V, Hier MP, Black MJ, Tamilia M. Female gender as a risk factor for transient post-thyroidectomy hypocalcemia. Otolaryngol Head Neck Surg. 2011;145(4):561-4. https://doi.org/10.1177/0194599811414511 PMid:21750342 DOI: https://doi.org/10.1177/0194599811414511

Zobel MJ, Long R, Gosnell J, Sosa JA, Padilla BE. Postoperative hypoparathyroidism after total thyroidectomy in children. J Surg Res. 2020;252:63-8. https://doi.org/10.1016/j.jss.2020.02.018 Mid:32234570 DOI: https://doi.org/10.1016/j.jss.2020.02.018

OzemirI A, Buldanli MZ, Yener O, Leblebici M, Eren T, Baysal H, et al. Factors affecting postoperative hypocalcemia after thyroid surgery: Importance of incidental parathyroidectomy. North Clin Istambul. 2016;3(1):9-14. https://doi.org/10.14744/nci.2016.48802 PMid:28058379 DOI: https://doi.org/10.14744/nci.2016.48802

Eismontas V, Slepavicius A, Janusonis V, Zeromskas P, Beisa V, Strupas K, et al. Predictors of postoperative hypocalcemia occurring after a total thyroidectomy: Results of prospective multicenter study. BMC Surg. 2018;18(1):55. https://doi.org/10.1186/s12893-018-0387-2 PMid:30092793 DOI: https://doi.org/10.1186/s12893-018-0387-2

Kakava K, Tournis S, Papadakis G, Karelas I, Stampouloglou P, Kassi E, et al. Postsurgical hypoparathyroidism: A systematic review. In Vivo. 2016;30(3):171-80. PMid:27107072

Lorente-Poch L, Sancho J, Muñoz JL, Gallego-Otaegui L, Martínez-Ruiz C, Sitges-Serra A. Failure of fragmented parathyroid gland autotransplantation to prevent permanent hypoparathyroidism after total thyroidectomy. Langenbecks Arch Surg. 2017;402(2):281-7. https://doi.org/10.1007/s00423-016-1548-3 PMid:28064342 DOI: https://doi.org/10.1007/s00423-016-1548-3

Calò PG, Conzo G, Raffaelli M, Medas F, Gambardella C, DeCrea C, et al. Total thyroidectomy alone versus ipsilateral versus bilateral prophylactic central neck dissection in clinically node-negative differentiated thyroid carcinoma. A retrospective multicenter study. Eur J Surg Oncol. 2017;43(1):126-32. https://doi.org/10.1016/j.ejso.2016.09.017 PMid:27780677 DOI: https://doi.org/10.1016/j.ejso.2016.09.017

Pagana KD, Pagana TJ, Pagana TN. Mosby’s Diagnostic and Laboratory Test Reference. 14th ed. St. Louis, Mo: Elsevier; 2019. Available from: https://evolve.elsevier.com/cs/product/9780323675192?role=student. [Last accessed on 2021 May 12].

Filho E, Machry RV, Mesquita R, Scheffel RS, Maia AL. The timing of parathyroid hormone measurement defines the cut-off values to accurately predict postoperative hypocalcemia: A prospective study. Endocrine. 2018;61(2):224-31. https://doi.org/10.1007/s12020-018-1601-9 PMid:29721800 DOI: https://doi.org/10.1007/s12020-018-1601-9

Annerbo M, Hultin H, Stålberg P, Hellman P. Left-shifted relation between calcium and parathyroid hormone in Graves’ disease. J Clin Endocrinol Metab. 2014;99(2):545-51. https://doi.org/10.1210/jc.2013-2500 PMid:24248181 DOI: https://doi.org/10.1210/jc.2013-2500

Park I, Rhu J, Woo JW, Choi JH, Kim JS, Kim JH. Preserving parathyroid gland vasculature to reduce post-thyroidectomy hypocalcemia. World J Surg 2016;40(6):1382-9. https://doi.org/10.1007/s00268-016-3423-3 PMid:27028753 DOI: https://doi.org/10.1007/s00268-016-3423-3

Raffaelli M, De Crea C, D’Amato G, Moscato U, Bellantone C, Carrozza C, et al. Post-thyroidectomy hypocalcemia is related to parathyroid dysfunction even in patients with normal parathyroid hormone concentrations early after surgery. Surgery. 2016;159(1):78-84. https://doi.org/10.1016/j.surg.2015.07.038 PMid:26456131 DOI: https://doi.org/10.1016/j.surg.2015.07.038

Özden S, Erdoğan A, Simsek B, Saylam B, Yıldız B, Tez M. Clinical course of incidental parathyroidectomy: Single center experience. Auris Nasus Larynx. 2018;45(3):574-7. https://doi.org/10.1016/j.anl.2017.07.019 PMid:28807528 DOI: https://doi.org/10.1016/j.anl.2017.07.019

Karamanakos SN, Markou KB, Panagopoulos K, Karavias D, Vagianos CE, Scopa CD, et al. Complications and risk factors related to the extent of surgery in thyroidectomy. Results from 2,043 procedures. Hormones (Athens, Greece). 2010;9(4):318-25. https://doi.org/10.14310/horm.2002.1283 PMid:21112863 DOI: https://doi.org/10.14310/horm.2002.1283

Maxwell AK, Shonka DC, Jr., Robinson DJ, Levine PA. Association of preoperative calcium and calcitriol therapy with postoperative hypocalcemia after total thyroidectomy. JAMA Otolaryngol Head Neck Surg. 2017;143(7):679-84. https://doi.org/10.1001/jamaoto.2016.4796 PMid:28418509 DOI: https://doi.org/10.1001/jamaoto.2016.4796

Paduraru DN, Ion D, Carsote M, Andronic O, Bolocan A. Post-thyroidectomy hypocalcemia risk factors and management. Chirurgia. 2019;114:564-70. https://doi.org/10.21614/chirurgia.114.5.564 PMid:31670631 DOI: https://doi.org/10.21614/chirurgia.114.5.564

Kalyoncu D, Gonullu D, Gedik ML, Er M, Kuroğlu E, İğdem AA, et al. Analysis of the factors that have effect on hypocalcemia following thyroidectomy. Ulusal Cer Derg. 2013;29:171-6. https://doi.org/10.5152/UCD.2013.2438 PMid:25931872 DOI: https://doi.org/10.5152/UCD.2013.2438

Tolone S, Roberto R, Del Genio G, et al. The impact of age and oral calcium and Vitamin D supplements on postoperative hypocalcemia after total thyroidectomy: A prospective study. BMC Surg. 2013;13(2):S11. https://doi.org/10.5152/UCD.2013.2438 PMid:24267491 DOI: https://doi.org/10.1186/1471-2482-13-S2-S11

Riaz U, Shah SA, Zahoor I, Riaz A, Zubair M. Validity of early parathyroid hormone assay as a diagnostic tool for sub-total thyroidectomy related hypocalcaemia. J Coll Physicians Surg Pak. 2014;24(7):459-62. PMid:25052965

Cannizzaro MA, Lo Bianco S, Picardo MC, Provenzano D, Buffone A. How to avoid and to manage post-operative complications in thyroid surgery. Updates Surg. 2017;69(2):211-5. https://doi.org/10.1007/s13304-017-0475-3 PMid:28646422 DOI: https://doi.org/10.1007/s13304-017-0475-3

Bhettani MK, Rehman M, Ahmed M, Altaf HN, Choudry UK, Khan KH. Role of pre-operative Vitamin D supplementation to reduce post-thyroidectomy hypocalcemia; Cohort study. Int J Surg (London, England). 2019;71:85-90. https://doi.org/10.1016/j.ijsu.2019.08.035 PMid:31494332 DOI: https://doi.org/10.1016/j.ijsu.2019.08.035

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Published

2021-10-02

How to Cite

1.
Fuad M, Modher A. Assessment of Serum Ionized Calcium in the Perioperative Period in Patients Undergoing Total Thyroidectomy. Open Access Maced J Med Sci [Internet]. 2021 Oct. 2 [cited 2024 Nov. 23];9(B):1203-6. Available from: https://oamjms.eu/index.php/mjms/article/view/7018