Protective Potential of Ginseng and/or Coenzyme Q10 on Doxorubicin-induced Testicular and Hepatic Toxicity in Rats

Authors

  • Suzan Khodir Department of Medical Physiology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt https://orcid.org/0000-0002-2535-9445
  • Aliaa Alafify Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt https://orcid.org/0000-0003-4675-0977
  • Essam Omar Department of Medical Physiology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt https://orcid.org/0000-0001-5065-6620
  • Marwa Al-Gholam Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt

DOI:

https://doi.org/10.3889/oamjms.2021.7063

Keywords:

Doxorubicin, Nuclear factor E2‐related factor 2, Caspase-3, Ginseng, Coenzyme Q10

Abstract

Introduction: Although doxorubicin (DOX) is a successful cancer chemotherapeutic, side effects limit the clinical utility of DOX-based therapy, including male infertility and hepatotoxicity.

Objective: To evaluate the testicular and hepatoprotective effect of ginseng and/or coenzyme Q10 (CoQ10) in rats exposed to DOX and the possible underlying mechanisms.

Materials and Methods:  Fifty adult male albino rats were divided into (10/group), control, DOX group, DOX/Gin group, DOX/CoQ10 group and DOX/Gin+CoQ10 group. Serum testosterone, serum liver enzymes, fasting serum cholesterol and triglyceride (TG), tissue malondialdehyde (MDA), tissue superoxide dismutase (SOD), serum tumor necrosis factor-alpha (TNF-α), serum interleukin 6, serum interleukin 10, nuclear factor E2‐related factor 2 (Nrf2) gene expression in liver and testis and organ indices were measured.  Histopathological and immunohistochemical assessments of apoptotic marker kaspase3 in testis and liver were also performed.

Results DOX-induced toxicity is associated with a significant decrease in serum testosterone, testis and liver index values, testicular and hepatic SOD,  testicular and hepatic Nrf2 gene expression and serum interleukin 10. However, there was a significant increase in serum liver enzymes, serum cholesterol and TG, testicular and hepatic MDA, serum TNF-α and serum interleukin 6 when compared with the control group. The combination of ginseng and CoQ10 resulted in significant improvement of DOX-induced changes when compared with other treated groups.

Conclusion: Ginseng and CoQ10 have valuable therapeutic effects on DOX-induced testicular and hepatic toxicity via up-regulation of Nrf2 gene expression, inhibition of apoptosis, anti-oxidant, anti-inflammatory and hypolipidemic effects.

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2021-11-12

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Khodir S, Alafify A, Omar E, Al-Gholam M. Protective Potential of Ginseng and/or Coenzyme Q10 on Doxorubicin-induced Testicular and Hepatic Toxicity in Rats. Open Access Maced J Med Sci [Internet]. 2021 Nov. 12 [cited 2024 Mar. 28];9(A):993-1005. Available from: https://oamjms.eu/index.php/mjms/article/view/7063

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