The Avocado (Persea americana Mill.) Leaf Extract on Streptozotocin-induced Pancreatic Cell Regeneration of White Rats (Rattus norvegicus)

Authors

  • Nurdin Rahman Department of Nutrition, Faculty of Public Health, Universitas Tadulako, City of Palu, Indonesia
  • I. Made Tangkas Department of Nutrition, Faculty of Public Health, Universitas Tadulako, City of Palu, Indonesia
  • Sri Muliyani Sabang Department of Chemistry Education, Faculty of Teacher Training and Education, Universitas Tadulako, City of Palu, Indonesia
  • Bohari Bohari Department of Nutrition, Universitas Sultan Ageng Tirtayasa, City of Serang, Indonesia https://orcid.org/0000-0001-7257-639X
  • Rukman Abdullah Department of Medical Education, Universitas Sultan Ageng Tirtayasa, City of Serang, Indonesia https://orcid.org/0000-0002-2032-530X

DOI:

https://doi.org/10.3889/oamjms.2021.7065

Keywords:

Avocado leaf extract, Histology, Pancreas, Diabetes mellitus

Abstract

Objectibe The rate of pancreatic cell regeneration after avocado leaf extract intervention in a diabetic animal model induced by streptozotocin was investigated in this study. Method: Experimental study was conducted on 18 male white rats as subjects, which were divided into 6 groups, 3 animals of each. Those were G1 (Feed + Streptozotocin + 10% Sucrose + 100 mg/kg b.w. of extract + 0.5% NaCMC), G2 (Feed + Streptozotocin + 10% Sucrose + 150 mg/kg b.w. of extract + 0.5% NaCMC), G3 (Feed + Streptozotocin + 10% Sucrose + 200 mg/kg b.w. of extract + 0.5% NaCMC), G4 (Feed + Streptozotocin + 10% sucrose + 0.5% Na-CMC), G5 (Feed + Streptozotocin + 10% sucrose + Glibenclamid + 0.5% Na-CMC), G6 (Normal healthy animal + Feed). Results: The pancreatic cells damage in animal diabetic model, G1 = 1.67 (moderate cell damage); G2 = 1.00 (mild cell damage); G3 = 0.33 (no damage); G4 = 3.00 (severe cell damage); G5 = 0.33 (no damage); G6 = 0.33 (no damage). Conclusion: The dose of 200 mg/kg b.w. of avocado leaf extract contributed the most significant recovery of pancreatic cell of diabetic animal induced with streptozotocin, equivalent to glibenclamide.

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Published

2021-10-10

How to Cite

1.
Rahman N, Tangkas IM, Sabang SM, Bohari B, Abdullah R. The Avocado (Persea americana Mill.) Leaf Extract on Streptozotocin-induced Pancreatic Cell Regeneration of White Rats (Rattus norvegicus). Open Access Maced J Med Sci [Internet]. 2021 Oct. 10 [cited 2024 Mar. 28];9(A):849-53. Available from: https://oamjms.eu/index.php/mjms/article/view/7065

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