The Effectiveness of Sechium edule Jacq. Swartz Extract Changes in the Histopathology of Aspirin-Induced Rat Gastritis Model

Hendrika Silitonga; Gontar A. Siregar; Rosita Juwita Sembiring; Marline Nainggolan

doi:10.3889/oamjms.2021.7072

Authors

Hendrika Silitonga Doctoral Program, Faculty of Medicine, Universitas Sumatera Utara, Kota Medan, Indonesia; Department of Histology, Faculty of Medicine, Universitas Methodist Indonesia, Kota Medan, Indonesia
Gontar A. Siregar Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Kota Medan, Indonesia
Rosita Juwita Sembiring Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Kota Medan, Indonesia
Marline Nainggolan Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Kota Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.7072

Keywords:

Aspirin, Gastritis, Sechium edule Jacq. Swartz

Abstract

BACKGROUND: Gastritis is one of the most common diseases found in internal medicine clinics and daily life.

AIM: The purpose of this study was to determine the histopathological changes of gastric rat model of aspirin-induced gastritis.

MATERIALS AND METHODS: Group K(−) is a negative control (normal) not given any treatment, Group K(+) is a positive control induced by aspirin 200 mg/kgBW, Group 1 (P1) is a treatment group induced by aspirin 200 mg/kgBW with ethanol extract of chayote 100 mg/kgBW, po, Group 2 (P2) was the treatment group induced by aspirin 200 mg/kgBW with ethanol extract of chayote 200 mg/kgBW, po, Group 3 (P3) was the treatment group induced by aspirin 200 mg/kgBW with ethyl acetate fraction chayote 100 mg/kgBW, PO, Group 4 (P4) was the treatment group induced by aspirin 200 mg/kgBW with ethyl acetate fraction chayote 200 mg/kgBW, PO, and Group 5 (P5) was the treatment group induced by aspirin 200 mg/kgBW with omeprazole 20 mg.

RESULTS: Analysis of the results of inflammatory infiltration in gastric histopathology in Groups P1, P2, P3, and P4 showed mild inflammatory infiltration compared to Groups P(5) and K(+). The description of the acinar glands on gastric histopathology showed that the P2 group gave a better picture of the acinar gland repair than the K(+), P2, P3, P4, and P5 groups.

CONCLUSION: This study showed that ethanol extracts of squash 200 mg/KgBW own effectiveness as an anti-inflammatory on the improvement of infiltration of inflammatory and picture histopathological gastric mice compared with the ethanol extract of squash 100 mg/kg, the fraction of ethyl acetate chayote 100 mg/KgBW and 200 mg/KgBW and omeprazole 20 mg.

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