Complete Molar Pregnancy in Postmenopausal Woman: A Rare Case Report

Authors

  • Sutrisno Sutrisno Department of Obstetrics and Gynecology, Division of Human Reproductive Endocrinology and Fertility, RSUD Saiful Anwar Malang, Faculty of Medicine, Brawijaya University Indonesia, Malang, Indonesia https://orcid.org/0000-0003-1658-2992
  • Leny Farida Department of Emergency, RSUD Raja Ahmad Tabib, KEPRI Indonesia, Tanjung Pinang, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Brawijaya University Indonesia, Malang, Indonesia
  • Defri Defri Department of Obstetrics and Gynecology, RSUD Raja Ahmad Tabib, KEPRI Indonesia, Tanjung Pinang, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.7141

Keywords:

Molar pregnancy, Postmenopausal, Total abdominal hysterectomy

Abstract

BACKGROUND: Molar pregnancy, the form of the gestational trophoblastic disease (GTD), generally occurs in women of the reproductive age group, and rarely occurs in postmenopausal women. To present a rare case of molar pregnancy in a postmenopausal woman.

CASE REPORT: A multiparous woman aged 54 years was referred to the outpatient department at Raja Ahmad Tabib General Hospital of Riau Island, Indonesia with the main symptoms of nausea and vomiting profusely with 1 month before, lower abdominal pain, lump in the abdomen, abnormal vaginal bleeding, and a positive urine pregnancy test. Her last menstrual bleeding was 14 months ago. Physical examination found stable hemodynamic within blood pressure 150/95 mmHg. Laboratory results showed Hb 11.7 g/dL, positive urine pregnancy test, and serum β-HCG 292,876.1 mIU/mL. Ultrasound examination showed a vesicular pattern in the uterine cavity without fetal tissue. The patient was managed by elective total abdominal bilateral hysterectomy salpingo-oophorectomy. The intraoperative finding was softened, enlarged uterus size of 14–16 weeks of pregnancy, and no local spreading of disease. The patient was discharged on the 3 day after surgery.

CONCLUSION: Even though molar pregnancy is rare, it can occur in the postmenopausal woman. Therefore, GTD has remained in the differential diagnosis of postmenopausal bleeding which can prevent delay in diagnosis and management. Definitive treatment with total abdominal hysterectomy has been chosen in menopausal women who do not wish to preserve their fertility and prevent any malignant sequelae.

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References

Cunningham FG, Williams JF. William Obstetrics. 23rd ed. New York, USA: McGraw-Hill; 2012.

Bruce S, Sorosky J. Gestational trophoblastic disease. In: Stat Pearls. Treasure Island, FL: Stat Pearls Publishing; 2021. PMid:29261918

Lurain JR. Gestational trophoblastic disease I: Epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010;203(6):531-9. https://doi.org/10.1016/j.ajog.2010.06.073 PMid:20728069 DOI: https://doi.org/10.1016/j.ajog.2010.06.073

Tham BW, Everard JE, Tidy JA, Drew D, Hancock BW. Gestational trophoblastic disease in the Asian population of Northern England and North Wales. BJOG. 2003;110:555-9. PMid:12798471 DOI: https://doi.org/10.1046/j.1471-0528.2003.01413.x

Sebire NJ, Fisher RA, Foskett M, Rees H, Seckl MJ, Newlands ES. Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. BJOG. 2003;110(1):22-6. PMid:12504931 DOI: https://doi.org/10.1046/j.1471-0528.2003.02388.x

Schorge JO, Schorge JO, Bradshaw KD, Halvorson LM, Schaffer JI, Corton MM. Williams Gynecology. New York, USA: McGraw-Hill; 2008.

Cavaliere A, Ermito S, Dinatale A, Pedata R. Management of molar pregnancy. J Prenat Med. 2009;3(1):15-7. PMid:22439034

Dhanapal M, Padmapriya P, Pandian A. A hydatidiform mole in a postmenopausal women. Int J Reprod Contracept Obstet Gynecol. 2018;7:2500-2. DOI: https://doi.org/10.18203/2320-1770.ijrcog20182376

Sebire NJ, Foskett M, Fisher RA, Rees H, Seckl M, Newlands E. Risk of partial and complete hydatidiform molar pregnancy in relation to maternal age. BJOG. 2002;109(1):99-102. https://doi.org/10.1111/j.1471-0528.2002.t01-1-01037.x PMid:11843379 DOI: https://doi.org/10.1111/j.1471-0528.2002.t01-1-01037.x

Mangili G, Giorgione V, Gentile C, Bergamini A, Pella F, Almirante G, et al. Hydatidiform mole: Age-related clinical presentation and high rate of severe complications in older women. Acta Obstet Gynecol Scand. 2014;93(5):503-7. https://doi.org/10.1111/aogs.12357 PMid:24575838 DOI: https://doi.org/10.1111/aogs.12357

Mohammadjafari R, Abedi P, Najafabady MT. The gestational trophoblastic diseases: A ten year retrospective study. Cell J. 2010;4(1):1-4.

Tsukamoto N, Iwasaka T, Kashimura Y, Uchino H, Kashimura M, Matsuyama T. Gestational trophoblastic disease in women aged 50 or more. Gynecol Oncol. 1985;20(1):53-61. https://doi.org/10.1016/0090-8258(85)90124-6 PMid:2981190 DOI: https://doi.org/10.1016/0090-8258(85)90124-6

Jequier A, Winterton WR. Diagnostic problems of trophoblastic disease in women aged 50 or more. Obstet Gynecol. 1973;42(3):378-87. PMid:4353348

Mehrotra S, Singh U, Chauhan S. Molar pregnancy in postmenopausal women: A rare phenomenon. BMJ Case Rep. 2012;2012:bcr2012006213. https://doi.org/10.1136/bcr-2012-006213 PMid:22967678 DOI: https://doi.org/10.1136/bcr-2012-006213

Sun SY, Melamed A, Goldstein DP, Bernstein MR, Horowitz NS, Moron AF, et al. Changing presentation of complete hydatidiform mole at the New England trophoblastic disease center over the past three decades: Does early diagnosis alter risk for gestational trophoblastic neoplasia? Gynecol Oncol. 2015;138(1):46-9. https://doi.org/10.1016/j.ygyno.2015.05.002 PMid:25969351 DOI: https://doi.org/10.1016/j.ygyno.2015.05.002

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Published

2021-11-10

How to Cite

1.
Sutrisno S, Farida L, Defri D. Complete Molar Pregnancy in Postmenopausal Woman: A Rare Case Report. Open Access Maced J Med Sci [Internet]. 2021 Nov. 10 [cited 2024 Apr. 19];9(C):315-7. Available from: https://oamjms.eu/index.php/mjms/article/view/7141

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Case Reports in Gynecology and Obstetrics

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