The Clinical Course of Rheumatoid Arthritis in Kazakhstani Patients

Argul Issilbayeva; Assel  Meiramova; Almagul R. Kushugulova; Zhanar B. Akhmetova; Damir  Biktashev; Baglan B. Abdakhina; Aliya T. Aituganova; Yekaterina  Zueva; Karina Karlygash; Bayan A. Ainabekova

doi:10.3889/oamjms.2021.7157

Authors

Argul Issilbayeva Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan; Department of Internal Medicine with the Course of Gastroenterology, Endocrinology and Pulmonology, NJSC Astana Medical University, Nur-Sultan, Kazakhstan https://orcid.org/0000-0002-7350-6083
Assel Meiramova Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan; Department of Internal Medicine with the Course of Gastroenterology, Endocrinology and Pulmonology, NJSC Astana Medical University, Nur-Sultan, Kazakhstan https://orcid.org/0000-0002-4030-0783
Almagul R. Kushugulova Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan
Zhanar B. Akhmetova Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan; Department of Internal Medicine with Geriatrics course, NJSC Astana Medical University, Nur-Sultan, Kazakhstan
Damir Biktashev Department of Internal Medicine with the Course of Gastroenterology, Endocrinology and Pulmonology, NJSC Astana Medical University, Nur-Sultan, Kazakhstan https://orcid.org/0000-0003-4364-3586
Baglan B. Abdakhina Department of Internal Medicine with the Course of Gastroenterology, Endocrinology and Pulmonology, NJSC Astana Medical University, Nur-Sultan, Kazakhstan
Aliya T. Aituganova Department of Internal Medicine with the Course of Gastroenterology, Endocrinology and Pulmonology, NJSC Astana Medical University, Nur-Sultan, Kazakhstan
Yekaterina Zueva Department of Molecular Biology, Ariel University, Medical Faculty, Ashkelon, Israel https://orcid.org/0000-0001-7460-6003
Karina Karlygash Department of Internal Medicine with the Course of Gastroenterology, Endocrinology and Pulmonology, NJSC Astana Medical University, Nur-Sultan, Kazakhstan
Professor Bayan Alkenovna Department of Internal Medicine with the Course of Gastroenterology, Endocrinology and Pulmonology, NJSC Astana Medical University, Nur-Sultan, Kazakhstan

DOI:

https://doi.org/10.3889/oamjms.2021.7157

Keywords:

Anti-citrullinated protein/peptide antibody, Clinic, Rheumatoid arthritis, Rheumatoid factor

Abstract

BACKGROUND: Rheumatoid arthritis (RA) prevalence according to the worldwide epidemiological data varies from 0.4% to 1.3%. The disability and mortality rate in RA is high. RA clinic is various, and compiles from articular and systemic manifestations.

AIM: The aim of our study was to investigate the clinical course of RA in Kazakhstani patients living in North region of our country.

METHODS: The 81 women at the age of 30–55 years with a verified diagnosis of RA who have lived in Kazakhstan for at least 10 years were recruited to the study. All participants were examined by the rheumatologist and a standard laboratory examination was carried out. Statistical analysis was conducted in IBM SPSS Statistics 26 software (IBM.USA;1).

RESULTS: The statistically significant higher frequency of erosive radiological stages, bone ankylosis (χ²= 18.070 df = 6 p = 0.005) was found in seropositive (rheumatoid factor [RF]+) anti-citrullinated protein/peptide antibody positive (ACPA+) subgroup. The correlation analysis showed strong association between certain RA form activity and inflammatory markers, as well as disease triggers. The discriminant model which predicts the stage of radiological damage was obtained. The sensitivity of model in predicting X-ray Stage I-71.6%, Stage II-29.4%, Stage III-37.5%, and Stage IV-63.6%.

CONCLUSION: The debut of the RA on average occurred in the third decade of the patients’ life. The joint syndrome had a more unfavorable character RF+ACPA+ patients’ subgroup; however, RF+ACPA-negative (ACPA-) subgroup also showed a predisposition to poorer prognosis. The obtained discriminant model may be useful for RA patients’ management.

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Author Biography

Almagul R. Kushugulova, Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan

Professor, Director of Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan

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