The Impact of Resistance Training on Gene Expression of IGF1 and Athletes’ Physiological Parameters

Authors

  • Mohammed Nader Shalaby Department of Biological Sciences and Sports Health, Faculty of Physical Education, Suez Canal University, Ismailia, Egypt https://orcid.org/0000-0002-0228-3003
  • Mona Mostafa Abdo Sakoury Department of General Courses https://orcid.org/0000-0002-0228-3003
  • Ellie Abdi Center of Pedagogy
  • Shaimaa Elgamal Department of Health Sciences, Faculty of Physical Education for Girls, Alexandria University, Alexandria, Egypt
  • Shaimaa Elrkbwey Department of Health Sciences, Faculty of Physical Education for Girls, Alexandria University, Alexandria, Egypt
  • Wael Ramadan Department of Sports Training
  • Redha Taiar Department of Physical and Sports Education https://orcid.org/0000-0003-3822-8329

DOI:

https://doi.org/10.3889/oamjms.2021.7215

Keywords:

Insulin-like growth factor 1, Resistance training, Gene expression, Muscular strength

Abstract

AIM: The purpose of this study was to verify the effect of a resistance training program for 8 weeks on IGF1, gene expression, and physical performance in male student-athletes.

METHODS: The population of this study was 20 male students divided to two equal groups. The parameters estimated were IGF1, gene expression, and muscle strength testing. Blood was drawn to verify the concentration of the variables, using kits and Elisa method in addition to the PCR technique.

RESULTS: The results revealed that a significant increase in IGF1, gene expression was different between students. Furthermore, muscle strength testing revealed significant changes.

CONCLUSION: The results suggested that resistance training program may impact fitness and muscle strength as well the anabolic activity through IGF1 increase accompanied by varied gene expressions.

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References

Shalaby MN, Hussien S, Abdo Sakoury MM, Atiaa AM, Galila MA. The impact of antioxidants in blood pressure and free radicals of athletes. Indian J Forensic Med Toxicol. 15(2):4420-30. http://doi.org/10.37506/ijfmt.v15i2.15062. DOI: https://doi.org/10.37506/ijfmt.v15i2.15062

Hussien S, Morad DF, Ibrahim NM, Shalaby MN. The effect of using an exercise-nutrition program on some physiological variables on diabetes patients. Indian J Forensic Med Toxicol. 2021;15(2):4030-9. http://doi.org/10.37506/ijfmt.v15i2.15005. DOI: https://doi.org/10.37506/ijfmt.v15i2.15005

Shalaby MN, Fadl MA. Relative indicators and predicative ability of some biological variables on cardiac neural activity for volleyball players. Syst Rev Pharm. 2020;11(9):834-40.

Barton-Davis ER, Shoturma DI, Musaro A, Rosenthal N, Sweeney HL. Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function. Proc Natl Acad Sci. 1998;95(26):15603-7. DOI: https://doi.org/10.1073/pnas.95.26.15603

Ganguly K. Overview of the internal physiological system of the human body. In: Application of Biomedical Engineering in Neuroscience. Berlin: Springer; 2019. p. 3-38. DOI: https://doi.org/10.1007/978-981-13-7142-4_1

Humbel RE. Insulin-like growth factors I and II. Eur J Biochem. 1990;190(3):445-62. http://doi.org/10.1111/j.1432-1033.1990.tb15595.x PMid:2197088 DOI: https://doi.org/10.1111/j.1432-1033.1990.tb15595.x

Shalaby MN, Fadl MA. A proposed training program and its effect on muscle strength responses and some physiological variables for volleyball beginners. Syst Rev Pharm. 2020;11(12):515-9.

Shalaby M, Sakoury MM, Harthi SM, Alshalawi FM, Alhajji MM, Alshaikh ZH, et al. Vitamin D3 for health and muscle functions of athletes. Syst Rev Pharm. 2020;11(9):851-4.

Hall JE, Hall ME. Guyton and Hall Textbook of Medical Physiology e-Book. Amsterdam, Netherlands: Elsevier Health Sciences; 2020.

Mougios V. Exercise Biochemistry. Champaign, Illinois: Human Kinetics Publishers;, 2019. DOI: https://doi.org/10.5040/9781492595496

Grocott MP, Levett DZ, Ward SA. Exercise physiology: Exercise performance at altitude. Curr Opin Physiol. 2019;10:210-8. DOI: https://doi.org/10.1016/j.cophys.2019.06.008

Hedelin R, Kenttä G, Wiklund U, Bjerle PE, Henriksson- Larsén K. Short-term overtraining: Effects on performance, circulatory responses, and heart rate variability. Med Sci Sports Exerc. 2000;32(8):1480-4. http://doi.org/10.1097/00005768-200008000-00017 PMid:10949015 DOI: https://doi.org/10.1097/00005768-200008000-00017

Bloom SR, Johnson RH, Park DM, Rennie MJ, Sulaiman WR. Differences in the metabolic and hormonal response to exercise between racing cyclists and untrained individuals. J Physiol. 1976;258(1):1-18. http://doi.org/10.1113/jphysiol.1976.sp011403 PMid:940045 DOI: https://doi.org/10.1113/jphysiol.1976.sp011403

García-López D, Häkkinen K, Cuevas MJ, Lima E, Kauhanen A, Mattila M, et al. Effects of strength and endurance training on antioxidant enzyme gene expression and activity in middle-aged men. Scand J Med Sci Sports. 2007;17(5):595-604. http://doi.org/10.1111/j.1600-0838.2006.00620.x PMid:17316373 DOI: https://doi.org/10.1111/j.1600-0838.2006.00620.x

Denegar CR, Perrin DH. Effect of transcutaneous electrical nerve stimulation, cold, and a combination treatment on pain, decreased range of motion, and strength loss associated with delayed onset muscle soreness. J Athl Train. 1992;27(3):200-6. PMid:16558162

NaderShalaby M, Liu JY, Heshmat H, Shalaby NM, Salah M. The effect of aerobic and anaerobic exercise bouts on CD34+ stem cells and some physiological parameters. Life Sci J. 2012;9(2):1037-43.

Lyu Y, Xue L, Zhang F, Koch H, Saba L, Kechirs K, et al. Condition-adaptive fused graphical lasso (CFGL): An adaptive procedure for inferring condition-specific gene co-expression network. PLoS Comput Biol. 2018;14(9):e1006436. DOI: https://doi.org/10.1371/journal.pcbi.1006436

Impellizzeri FM, Marcora SM, Castagna C, Reilly T, Sassi A, Iaia FM, et al. Physiological and performance effects of generic versus specific aerobic training in soccer players. Int J Sports Med. 2006;27(6):483-92. http://doi.org/10.1055/s-2005-865839 PMid:16767613 DOI: https://doi.org/10.1055/s-2005-865839

Buzi F, Mella P, Pilotta A, Prandi E, Lanfranchi F, Carapella T. Growth hormone receptor polymorphisms. Congenit Endocrinopathies. 2007;11:28-35. DOI: https://doi.org/10.1159/000111055

Williams RH. Textbook of Endocrinology. Acad Med. 1962;37(5):527.

Morikawa A, Inamizu T, Han Y, Nagata M. Effects of exercise training on superoxide dismutase gene expression in human lymphocytes. Int J Sport Health Sci. 2004;2:187-94. DOI: https://doi.org/10.5432/ijshs.2.187

Lis K. Insulin-like growth factor 1 (IGF-1) and growth hormone (hGH) as the markers of osteoarthritis. Chir Narzadow Ruchu Ortop Pol. 2008;73(1):49-52. PMid:18683531

Kostek MC, Delmonico MJ, Reichel JB, Roth SM, Douglass L, Ferrell RE, et al. Muscle strength response to strength training is influenced by insulin-like growth factor 1 genotype in older adults. J Appl Physiol. 2005;98(6):2147-54. http://doi.org/10.1152/japplphysiol.00817.2004 PMid:15894537 DOI: https://doi.org/10.1152/japplphysiol.00817.2004

Kim B, Leventhal PS, White MF, Feldman EL. Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells. Endocrinology. 1998;139(12):4881-9. http://doi.org/10.1210/endo.139.12.6348 PMid:9832424 DOI: https://doi.org/10.1210/endo.139.12.6348

Gaur S, Schwartz Y, Tai LR, Frick GP, Goodman HM. Insulin produces a growth hormone-like increase in intracellular free calcium concentration in okadaic acid-treated adipocytes. Endocrinology. 1998;139(12):4953-61. http://doi.org/10.1210/endo.139.12.6387 PMid:9832433 DOI: https://doi.org/10.1210/endo.139.12.6387

Jain S, Golde DW, Bailey R, Geffner ME. Insulin-like growth factor-I resistance. Endocr Rev. 1998;19(5):625-46. http://doi.org/10.1210/edrv.19.5.0348 PMid:9793761 DOI: https://doi.org/10.1210/edrv.19.5.0348

Shalaby MN, Liu JY, Saad M, Elaraby H. Impacts of different exercise intensities on hematopoietic stem cells and certain physiological parameters on handball players and non-athletes. Life Sci J. 2012;9(3):2100-5.

Neuhausen SL, Slattery ML, Garner CP, Ding YC, Hoffman M, Brothman AR. Prostate cancer risk and IRS1, IRS2, IGF1, and INS polymorphisms: Strong association of IRS1 G972R variant and cancer risk. Prostate. 2005;64(2):168-74. http://doi.org/10.1002/pros.20216 PMid:15678496 DOI: https://doi.org/10.1002/pros.20216

Alemdaroğlu U. The relationship between muscle strength, anaerobic performance, agility, sprint ability and vertical jump performance in professional basketball players. J Hum Kinet. 2012;31(1):149-58. PMid:23486566 DOI: https://doi.org/10.2478/v10078-012-0016-6

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Published

2021-11-13

How to Cite

1.
Shalaby MN, Sakoury MMA, Abdi E, Elgamal S, Elrkbwey S, Ramadan W, Taiar R. The Impact of Resistance Training on Gene Expression of IGF1 and Athletes’ Physiological Parameters. Open Access Maced J Med Sci [Internet]. 2021 Nov. 13 [cited 2024 Mar. 29];9(A):934-40. Available from: https://oamjms.eu/index.php/mjms/article/view/7215

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