Renal AML Surgically Treated 33 Cases

Mohamed  Salama; Amr Mostafa; Nada Salama; Mona Alabrak; Shaimaa Abdalaleem; Ayman Hanafy

doi:10.3889/oamjms.2022.7300

Authors

Mohamed Salama Department of Surgical Oncology, National Cancer Institute, Cairo University, Giza, Egypt
Amr Mostafa Department of Urology
Nada Salama Department of Radiology, National Cancer Institute, Cairo University, Giza, Egypt https://orcid.org/0000-0001-7317-0623
Mona Alabrak Department of Pathology, National Cancer Institute, Cairo University, Giza, Egypt https://orcid.org/0000-0002-6620-3738
Shaimaa Abdalaleem Department of Biostatistics and Epidemiology, National Cancer Institute, Cairo University, Giza, Egypt https://orcid.org/0000-0003-0994-7703
Ayman Hanafy Department of Surgical Oncology, National Cancer Institute, Cairo University, Giza, Egypt

DOI:

https://doi.org/10.3889/oamjms.2022.7300

Keywords:

Renal angiomyolipoma, Renal mass, Tuberous sclerosis

Abstract

BACKGROUND: Renal angiomyolipoma (RAML) is a rare benign neoplasm with a prevalence varying between 0.2% and 0.6% and a strong female predilection. They occur as sporadic, isolated entities in 80% of cases. The remaining 20% of angiomyolipomas (AMLs) develop in association with tuberous sclerosis complex or pulmonary lymphangioleiomyomatosis.

AIM: We describe our 10-year experience with AML and discuss the treatment strategies employed at our center.

METHODS: The medical records of all 33 patients with pathologically confirmed RAML treated either by nephrectomy or nephron-sparing surgery at our center over 10 years were reviewed for patient age and sex, tumor location and size, association with TBS.

RESULTS: There were 28 females (84.8%) and 5 males (15.2%) with a median age that was 52 (range 22–74) years at the time of surgery. Thirty patients (90.9%) had sporadic isolated AML, and 3 patients (9.1%) had AML with TBS. The tumor was in the right kidney in 15 (45.5%) patients, in the left kidney in 17 (51.5%) patients, and bilateral in only 1 patient (3%) who was diagnosed with TBS. At presentation, flank pain was the main symptom in 23 patients (69.7%).

CONCLUSIONS: Surgical resection of RAML provides short-term symptomatic relieve and long-term survival.

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