Interleukin-6 as Immune System and Inflammation Biomarker on the Response of Basic Pencak Silat Exercise in Perguruan Pencak Silat Perisai Diri, Bojonegoro
Keywords:Immune system, Inflammation biomarker, Exercise, Martial art, Health and well-being
BACKGROUND: Pencak Silat is a self-defense exercise originated from Indonesia and categorized as a high-intensity exercise.
AIM: This research was intended to identify the acute response of Pencak Silat basic exercise toward interleukin-6 (IL-6) as an immune system biomarker on students of Perguruan Pencak Silat Perisai Diri Tulungrejo, Bojonegoro.
METHODS: A number of 26 students (10 boys and 16 girls) of Perguruan Pencak Silat Tulungrejo, Bojonegoro, were participated in this study. The students did the 2 h Perguruan Pencak Silat Perisai Diri, Bojonegoro, training program with 75–85% intensity. The IL-6 serum was measured using ELISA method.
RESULTS: The result of this study showed that the IL-6 serum level in post-2 (12 h after training) (6.2981 pg/mL) was higher compared with the IL-6 serum level in post-1 (shortly after training) (6.11981 pg/mL) and before training (4.5146 pg/mL). The result also showed that there was a significant difference of IL-6 levels between pre-training and after training.CONCLUSION: This study concluded that the basic exercise performed by the new students of Perguruan Pencak Silat Perisai Diri increased IL-6 serum level.
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Pedersen BK, Ullum H. NK cell response to physical activity: Possible mechanisms of action. Med Sci Sports Exerc. 1994;26(2):140-6. https://doi.org/10.1249/00005768-199402000-00003 PMid:8164530
Nieman DC, Pedersen BK. Exercise and immune function. Recent developments. Sports Med. 1999;27(2):73-80. https://doi.org/10.2165/00007256-199927020-00001 PMid:10091272
Gleeson M. Immune function in sport and exercise. J Appl Physiol (1985). 2007;103(2):693-9. PMid:17303714
Williams SL, Strobel NA, Lexis LA, Coombes JS. Antioxidant requirements of endurance athletes: Implications for health. Nutr Rev. 2006;64(3):93-108. https://doi.org/10.1111/j.1753-4887.2006.tb00193.x PMid:16572597
Ostrowski K, Rohde T, Zacho M, Asp S, Pedersen BK. Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. J Physiol. 1998;508(3):949-53. https://doi.org/10.1111/j.1469-7793.1998.949bp.x PMid:9518745
Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014;6(10):a016295. https://doi.org/10.1101/cshperspect.a016295 PMid:25190079
Pedersen BK, Steensberg A, Schjerling P. Exercise and interleukin-6. Curr Opin Hematol. 2001;8(3):137-41. PMid:11303145
Suzuki K. Cytokine response to exercise and its modulation. Antioxidants (Basel). 2018;7(1):17.
Yang H, Antonie DJ, Andersson U, Tracey KJ. The many faces of HMGB1: Molecular structure-functional activity in inflammation, apoptosis, and chemotaxis. J Leukoc Biol. 2013;93(6):865-73. https://doi.org/10.1189/jlb.1212662 PMid:23446148
Goh J, Hofmann P, Aw NH, Tan PL, Tschakert G, Mueller A, et al. Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: A pilot study. Transl Med Commun. 2020;5:4. https://doi.org/10.1186/s41231-020-00056-z
Pedersen BK, Steensberg A, Schjerling P. Exercise and interleukin-6 Curr Opin Hematol. 2001;8(3):137-41. PMid:11303145
Choy E, Rose-John S. Interleukin-6 as a multifunctional regulator: Inflammation, immune response, and fibrosis. J Scleroderma Relat Disord. 2017;2(2):S1-5. https://doi.org/10.5301/jsrd.5000265
Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res Ther. 2006;8 Suppl 2:S3. PMid:16899107
Damas P, Ledoux D, Nys M, Vrindts Y, de Groote D, Franchimont P, et al. Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg. 1992;215(4):356-62. https://doi.org/10.1097/00000658-199204000-00009 PMid:1558416
Schluter B, Konig B, Bergmann U, Muller FE, Konig W, “Interleukin-6, a potential mediator of lethal sepsis after major thermal trauma: Evidence for increased IL-6 production by peripheral blood mononuclear cells. J Trauma. 1991;31(12):1663-70. https://doi.org/10.1097/00005373-199112000-00017 PMid:1749040
Steensberg A, Toft AD, Schjerling P, Halkjær-Kristensen P, Pedersen BK. Plasma interleukin-6 during strenuous exercise: Role of epinephrine. Am J Physiol Cell Physiol. 2001;281(3):C1001-4. https://doi.org/10.1152/ajpcell.2001.281.3.c1001 PMid:11502577
Pedersen BK, Nieman DC. Exercise and immunology: Integration and regulation. Immunol Today. 1998;19(5):204-6. PMid:9613035
Pedersen BK, Toft AD. Effects of exercise on lymphocytes and cytokines. Br J Sports Med. 2000;34(4):246-51. Mid:10953894
Tvede N, Kappel M, Klarlund K, Duhn S, Halkjaer-Kristensen J, Kjaer M, et al. Evidence that the effect of bicycle exercise on blood mononuclear cell proliferative responses and subsets is mediated by epinephrine. Int J Sports Med. 1994;15(2):100-4. https://doi.org/10.1055/s-2007-1021028 PMid:8157368
Steensberg A, Fischer CP, Keller C, Møller K, Pedersen BK. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab. 2003;285:E433-7. https://doi.org/10.1152/ajpendo.00074.2003 PMid:12857678
Chan MH, McGee SL, Watt MJ, Hargreaves M, Febbraio MA. Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: Association with IL-6 gene transcription during contraction. FASEB J. 2004;18(14):1785-7. https://doi.org/10.1096/fj.03-1039fje PMid:15345683
Keller C, Steensberg A, Pilegaard H, Osada T, Saltin B, Pedersen BK, et al. Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: Influence of muscle glycogen content. FASEB J. 2001;15(14):2748-50. https://doi.org/10.1096/fj.01-0507fje PMid:11687509
Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: Regulation, integration, and adaptation. Physiol Rev. 2000;80(3):1055-81. PMid:10893431
Lyngsø D, Simonsen L, Bulow J. Interleukin-6 production in human subcutaneous abdominal adipose tissue: The effect of exercise. J Physiol. 2002;543(1):373-8. https://doi.org/10.1113/jphysiol.2002.019380 PMid:12181307
Fischer CP. Interleukin-6 in acute exercise and training: What is the biological relevance? Exerc Immunol Rev. 2006;12:6-33. PMid:17201070
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Copyright (c) 2021 Roy Irawan, Trias Mahmudiono, Tri Martiana (Author)
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Kementerian Riset dan Teknologi /Badan Riset dan Inovasi Nasional
Grant numbers Num: 8/E1/KPT/ 2020, 24th January 2020.