The Relationship between Serum Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index with Severity Levels of Gastroesophageal Reflux Disease: A Literature Review

Tri Asih Imro'ati; Titong  Sugihartono; Budi  Widodo; Eva Pravitasari  Nefertiti; Ivan  Rovian; I Gede  Nyoman Wibawa

doi:10.3889/oamjms.2021.7346

Authors

Tri Asih Imro'ati Department of Internal Medicine, Gastroenterohepatology Division, Faculty of Medicine, Universitas Airlangga, Universitas Airlangga Hospital, Surabaya, Indonesia
Titong Sugihartono Department of Gastroenterohepatology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Academic Hospital, Surabaya, Indonesia
Budi Widodo Department of Gastroenterohepatology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Academic Hospital, Surabaya, Indonesia
Eva Pravitasari Nefertiti Department of Histopathology, Faculty of Medicine, Universitas Hang Tuah, Surabaya, Indonesia
Ivan Rovian Department of Internal Medicine, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia
I Gede Nyoman Wibawa Department of Gastroenterohepatology, Sanglah Hospital, Bali, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.7346

Keywords:

Gastroesophageal reflux, Total oxidative status, Total antioxidant status, Oxidative stress index, Association

Abstract

Gastroesophageal reflux disease (GERD) is a global health problem in which the prevalence is increasing over periods. This disease is a significant cause of disorders in the upper gastrointestinal tract with very complex pathogenesis. Oxidative stress (OS) due to gastric acid reflux plays a role in the inflammatory response of the esophageal epithelium. Several OS markers have been widely studied and are thought to affect the severity degree of the esophageal mucosa. However, there has been no research on total oxidant status (TOS), total antioxidant status (TAS), and OS index (OSI) in the adult with GERD; hence the aim of this review was to determine the association between TOS, serum TAS, and OSI with the GERD degree. A literature review was conducted by searching articles related to the TOS, TAS, OSI, and its correlation with GERD degree on an online database, particularly Pubmed and Google scholar. We conclude that TAS and OSI might influence the severity of GERD; however, further clinical study is needed to prove this theory.

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References

Gyawali CP, Kahrilas PJ, Savarino E, Zerbib F, Mion F, Smout AJ, et al. Modern diagnosis of GERD: The Lyon consensus. Gut. 2018;67(7):1351-62. https://doi.org/10.1136/gutjnl-2017-314722 PMid:29437910 DOI: https://doi.org/10.1136/gutjnl-2017-314722

Ang D, How CH, Ang TL. Persistent gastro-oesophageal reflux symptoms despite proton pump inhibitor therapy. Singapore Med J. 2016;57(10):546-51. https://doi.org/10.11622/smedj.2016167 PMid:27779277 DOI: https://doi.org/10.11622/smedj.2016167

Indonesian Society of Gastroenterology (ISG). National consensus on the management of constipation in Indonesia 2010. Acta Med Indones. 2011;43(4):267-74. PMid:22156361

Hunt R, Armstrong D, Katelaris P, Afihene M, Bane A, Bhatia S, et al. World gastroenterology organisation global guidelines: GERD global perspective on gastroesophageal reflux disease. J Clin Gastroenterol. 2017;51(6):467-78. https://doi.org/10.1097/MCG.0000000000000854 PMid:28591069 DOI: https://doi.org/10.1097/MCG.0000000000000854

Altomare A, Guarino MPL, Cocca S, Emerenziani S, Cicala M. Gastroesophageal reflux disease: Update on inflammation and symptom perception. World J Gastroenterol. 2013;19(39):6523-6528. https://doi.org/10.3748/wjg.v19.i39.6523 PMid:24151376 DOI: https://doi.org/10.3748/wjg.v19.i39.6523

Deng Y, Pan L, Qian W. Associations between the severity of reflux esophagitis in children and changes in oxidative stress, serum inflammation, vasoactive intestinal peptide and motilin. Exp Ther Med. 2019;18(5):3509-13. https://doi.org/10.3892/etm.2019.7978 PMid:31602227 DOI: https://doi.org/10.3892/etm.2019.7978

Souza RF, Bayeh L, Spechler SJ, Tambar UK, Bruick RK. A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: A potential role for targeting HIF-2α _to prevent and treat reflux esophagitis. Curr Opin Pharmacol. 2017;37:93-9. https://doi.org/10.1016/j.coph.2017.10.004 PMid:29112883 DOI: https://doi.org/10.1016/j.coph.2017.10.004

Young I. Measurement of total antioxidant capacity. J Clin Pathol. 2001;54(5):339. https://doi.org/10.1136/jcp.54.5.339 PMid:11328830 DOI: https://doi.org/10.1136/jcp.54.5.339

Apak R, Gorinstein S, Böhm V, Schaich KM, Özyürek M, Güçlü K. Methods of measurement and evaluation of natural antioxidant capacity/activity (IUPAC Technical Report). Pure Appl Chem. 2013;85(5):957-98. https://doi.org/10.1351/pac-rep-12-07-15 DOI: https://doi.org/10.1351/PAC-REP-12-07-15

Huang Q, Feng J, Wu R, Yang Y, Dai C, Li J, et al. Total oxidant/antioxidant status in sera of patients with esophageal cancer. Med Sci Monit. 2017;23:3789-94. https://doi.org/10.12659/MSM.902210 PMid:28777781 DOI: https://doi.org/10.12659/MSM.902210

Iwakiri K, Kinoshita Y, Habu Y, Oshima T, Manabe N, Fujiwara Y, et al. Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015. J Gastroenterol. 2016;5(8):751-67. https://doi.org/10.1007/s00535-016-1227-8 PMid:27325300 DOI: https://doi.org/10.1007/s00535-016-1227-8

Sollano JD, Romano RP, Ibañez-Guzman L, Lontok MA, de Ocampo SQ, Policarpio AA, et al. Clinical practice guidelines on the diagnosis and treatment of gastroesophageal reflux disease (GERD). Phil J Intern Med. 2015;53(3):1-17. DOI: https://doi.org/10.1007/978-3-319-19524-7_1

Sami SS, Ragunath K. The Los Angeles classification of gastroesophageal reflux disease. Video J Encyclopedia GI Endosc. 2013;1(1):103-4. https://doi.org/10.1016/S2212-0971(13)70046-3 DOI: https://doi.org/10.1016/S2212-0971(13)70046-3

Savarino E, Bredenoord AJ, Fox M, Pandolfino JE, Roman S, Gyawali CP, et al. Advances in the physiological assessment and diagnosis of GERD. Nat Rev Gastroenterol Hepatol. 2017;14(11):665-76. https://doi.org/10.1038/nrgastro.2017.130 PMid:28951582 DOI: https://doi.org/10.1038/nrgastro.2017.130

Nejat Pish‐Kenari F, Qujeq D, Maghsoudi H. Some of the effective factors in the pathogenesis of gastro‐oesophageal reflux disease. J Cell Mol Med. 2018;22(12):6401-4. https://doi.org/10.1111/jcmm.13939 PMid:30320456 DOI: https://doi.org/10.1111/jcmm.13939

Tack J, Pandolfino JE. Pathophysiology of gastroesophageal reflux disease. Gastroenterology. 2018;154(2):277-88. https://doi.org/10.1053/j.gastro.2017.09.047 PMid:29037470 DOI: https://doi.org/10.1053/j.gastro.2017.09.047

Menezes MA, Herbella FA. Pathophysiology of gastroesophageal reflux disease. World J Surg. 2017;41(7):1666-71. https://doi.org/10.1007/s00268-017-3952-4 PMid:28258452 DOI: https://doi.org/10.1007/s00268-017-3952-4

Herregods TV, Bredenoord AJ, Smout AJ. Pathophysiology of gastroesophageal reflux disease: New understanding in a new era. Neurogastroenterol Motil. 2015;27(9):1202-13. https://doi.org/10.1111/nmo.12611 PMid:26053301 DOI: https://doi.org/10.1111/nmo.12611

Orlando RC. Pathophysiology of gastroesophageal reflux disease. J Clin. Gastroenterol. 2008;42(5):584-8. https://doi.org/10.1097/mcg.0b013e31815d0628 PMid:18364588 DOI: https://doi.org/10.1097/MCG.0b013e31815d0628

Lee YY, McColl KE. Pathophysiology of gastroesophageal reflux disease. Best Prac Res Clin Gastroenterol. 2013;27(3):339-51. https://doi.org/10.1016/j.bpg.2013.06.002 PMid:23998973 DOI: https://doi.org/10.1016/j.bpg.2013.06.002

Kahrilas PJ, Pandolfino JE. Pathophysiology of gastroesophageal reflux disease. In: Fisichella P, Soper N, Pellegrini C, Patti M, editors. Surgical Management of Benign Esophageal Disorders. London: Springer; 2014. p. 11-24. https://doi.org/10.1007/978-1-4471-5484-6_2 DOI: https://doi.org/10.1007/978-1-4471-5484-6_2

Zachariah RA, Goo T, Lee RH. Mechanism and pathophysiology of gastroesophageal reflux disease. Gastrointest Endosc Clin N Am. 2020;30(2):209-26. https://doi.org/10.1016/j.giec.2019.12.001 PMid:32146942 DOI: https://doi.org/10.1016/j.giec.2019.12.001

Diamant NE. Pathophysiology of gastroesophageal reflux disease. GI Motil Online. 2006;168-173. https://doi.org/10.1038/gimo21

MacFarlane B. Management of gastroesophageal reflux disease in adults: A pharmacist’s perspective. Integr Pharm Res Pract. 2018;7:41-52. https://doi.org/10.2147/iprp.s142932 PMid:29892570 DOI: https://doi.org/10.2147/IPRP.S142932

Buico A, Cassino C, Ravera M, Betta PG, Osella D. Oxidative stress and total antioxidant capacity in human plasma. Redox Rep. 2009;14(3):125-31. https://doi.org/10.1179/135100009X392557 PMid:19490754 DOI: https://doi.org/10.1179/135100009X392557

Forrester SJ, Kikuchi DS, Hernandes MS, Xu Q, Griendling KK. Reactive oxygen species in metabolic and inflammatory signaling. Circ Res. 2018;122(6):877-902. https://doi.org/10.1161/circresaha.117.311401 PMid:29700084 DOI: https://doi.org/10.1161/CIRCRESAHA.117.311401

Jozanov-Stankov O, Duric J, Dobutovic B, Isenović ER. Determination of total antioxidant status (TAS) as a biochemical parameter in control of workers health. Arch Biol Sci. 2009;61(3):375-82. https://doi.org/10.2298/abs0903375j DOI: https://doi.org/10.2298/ABS0903375J

Li Y, Browne RW, Bonner MR, Deng F, Tian L, Mu L. Positive relationship between total antioxidant status and chemokines observed in adults. Oxid Med Cell Longev. 2014;2014:693680. https://doi.org/10.1155/2014/693680 PMid:25254081 DOI: https://doi.org/10.1155/2014/693680

Karajibani M, Bakhshipour AR, Montazerifar F, Dashipour A, Rouhi S, Moradpor M. Pro-oxidant and antioxidant balance, anthropometric parameters, and nutrient intakes in gastro-esophageal reflux disease patients. Zahedan J Res Med Sci. 2018;20(4):e58553. https://doi.org/10.5812/zjrms.58553 DOI: https://doi.org/10.5812/zjrms.58553

Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-11. https://doi.org/10.1016/j.clinbiochem.2005.08.008 PMid:16214125 DOI: https://doi.org/10.1016/j.clinbiochem.2005.08.008

Habdous M, Herbeth B, Vincent-Viry M, Lamont JV, Fitzgerald PS, Visvikis S, et al. Serum total antioxidant status, erythrocyte superoxide dismutase and whole-blood glutathione peroxidase activities in the Stanislas cohort: Influencing factors and reference intervals. Clin Chem Lab Med. 2003;41(2):209-15. https://doi.org/10.1515/cclm.2003.034 PMid:12667009 DOI: https://doi.org/10.1515/CCLM.2003.034

Kusano C, Ferrari B. Total antioxidant capacity: A biomarker in biomedical and nutritional studies. J Cell Mol Biol. 2008;7(1):1-5.

Jansen EH, Beekhof PK, Cremers JW, Viezeliene D, Muzakova V, Skalicky J. Short-term stability of biomarkers of oxidative stress and antioxidant status in human serum. ISRN Biomark. 2013;2013:316528. https://doi.org/10.1155/2013/316528 DOI: https://doi.org/10.1155/2013/316528

Wu R, Feng J, Yang Y, Dai C, Lu A, Li J, et al. Significance of serum total oxidant/antioxidant status in patients with colorectal cancer. PLoS One. 2017;12(1):e0170003. https://doi.org/10.1371/journal.pone.0170003 PMid:28103261 DOI: https://doi.org/10.1371/journal.pone.0170003

Sánchez-Rodríguez MA, Mendoza-Núñez VM. Oxidative stress indexes for diagnosis of health or disease in humans. Oxid Med Cell Longev. 2019;2019:4128152. https://doi.org/10.1155/2019/4128152 PMid:31885788 DOI: https://doi.org/10.1155/2019/4128152

Jiménez P, Piazuelo E, Sánchez MT, Ortego J, Soteras F, Lanas A. Free radicals and antioxidant systems in reflux esophagitis and Barrett’s esophagus. World J Gastroenterol. 2005;11(18):2697-703. https://doi.org/10.3748/wjg.v11.i18.26 PMid:15884106 DOI: https://doi.org/10.3748/wjg.11.2697

Oh TY, Lee JS, Ahn BO, Cho H, Kim WB, Kim YB, et al. Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats. Gut. 2001;49(3):364-71. https://doi.org/10.1136/gut.49.3.364 PMid:11511558 DOI: https://doi.org/10.1136/gut.49.3.364

Murphy SJ, Anderson LA, Ferguson HR, Johnston BT, Watson PR, McGuigan J, et al. Dietary antioxidant and mineral intake in humans is associated with reduced risk of esophageal adenocarcinoma but not reflux esophagitis or Barrett’s esophagus. J. Nutr. 2010;140(10):1757-63. https://doi.org/10.3945/jn.110.124362 PMid:20702746 DOI: https://doi.org/10.3945/jn.110.124362